Zobrazeno 1 - 10
of 1 939
pro vyhledávání: '"Adult mouse"'
Autor:
Yee Hoon Foong, Blake Caldwell, Joanne L. Thorvaldsen, Christopher Krapp, Clementina A. Mesaros, Wanding Zhou, Rahul M. Kohli, Marisa S. Bartolomei
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
TET1/2/3 dioxygenases iteratively demethylate 5-methylcytosine, beginning with the formation of 5-hydroxymethylcytosine (5hmC). The post-mitotic brain maintains higher levels of 5hmC than most peripheral tissues, and TET1 ablation studies have unders
Externí odkaz:
https://doaj.org/article/15da1f095f5e460fb87e5885ecd73cc9
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2023)
IntroductionProtein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) is crucial for the elongation of O-mannosyl glycans. Mutations in POMGNT1 cause muscle-eye-brain (MEB) disease, one of the main features of which is anatomical abe
Externí odkaz:
https://doaj.org/article/1b3190bf5b04429484197f6469e4f20d
Autor:
Carola Torazza, Francesca Provenzano, Elena Gallia, Maria Cerminara, Matilde Balbi, Tiziana Bonifacino, Sara Tessitore, Silvia Ravera, Cesare Usai, Ilaria Musante, Aldamaria Puliti, Ludo Van Den Bosch, Paymaan Jafar-nejad, Frank Rigo, Marco Milanese, Giambattista Bonanno
Publikováno v:
Cells, Vol 12, Iss 15, p 1952 (2023)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in ALS, which results in MN damage. Glutamate (Glu)-mediated excitotoxicit
Externí odkaz:
https://doaj.org/article/61d3dbab73534bc6bd2a4c90930293f8
Autor:
Mani Saminathan, Karam Pal Singh, Madhulina Maity, Sobharani Vineetha, Gundallhalli Bayyappa Manjunathareddy, Kuldeep Dhama, Yashpal Singh Malik, Muthannan Andavar Ramakrishnan, Jyoti Misri, Vivek Kumar Gupta
Publikováno v:
Journal of Advanced Research, Vol 31, Iss , Pp 137-153 (2021)
Introduction: Wild-type adult mice with intact interferon (IFN) system were neither susceptible to bluetongue virus (BTV) infection nor showed signs of morbidity/mortality. Establishment of immunologically competent wild-type adult mouse model with t
Externí odkaz:
https://doaj.org/article/c92d5a28548d45e2b8f153817a2cae98
Publikováno v:
Cells, Vol 12, Iss 12, p 1570 (2023)
Central nervous system infections caused by pathogens crossing the blood–brain barrier are extremely damaging and trigger cellular alterations and neuroinflammation. Bacterial brain infection, in particular, is a major cause of hippocampal neuronal
Externí odkaz:
https://doaj.org/article/866d2079faac48c988ba910a925273d1
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 38 (2022)
Inner ear gene therapy using adeno-associated viral vectors (AAVs) in neonatal mice can alleviate hearing loss in mouse models of deafness. However, efficient and safe transgene delivery to the adult mouse cochlea is critical for the effectiveness of
Externí odkaz:
https://doaj.org/article/c3f2d44a98994e7d9101f3840bd2e74b
Akademický článek
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Autor:
Shuo Chen, Junjun Jing, Yuan Yuan, Jifan Feng, Xia Han, Quan Wen, Thach-Vu Ho, Chelsea Lee, Yang Chai
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108007- (2020)
Summary: Stem cell niches provide a microenvironment to support the self-renewal and multi-lineage differentiation of stem cells. Cell-cell interactions within the niche are essential for maintaining tissue homeostasis. However, the niche cells suppo
Externí odkaz:
https://doaj.org/article/cc556a8dac024a328fea9a124165b6fa
Autor:
Xiaoyan Sun, Alexandra Are, Karl Annusver, Unnikrishnan Sivan, Tina Jacob, Tim Dalessandri, Simon Joost, Anja Füllgrabe, Marco Gerling, Maria Kasper
Publikováno v:
eLife, Vol 9 (2020)
Hair follicle (HF) development is orchestrated by coordinated signals from adjacent epithelial and mesenchymal cells. In humans this process only occurs during embryogenesis and viable strategies to induce new HFs in adult skin are lacking. Here, we
Externí odkaz:
https://doaj.org/article/e5a8e803ef724159ae6387f916f7d0e4
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2005 Dec . 102(52), 19180-19185.
Externí odkaz:
https://www.jstor.org/stable/4152585