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pro vyhledávání: '"Adult Acute Myeloid Leukemia"'
Akademický článek
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Autor:
Botheina Ahmed Thabet Farweez, Nahela Ahmed Shalaby, Doaa Ahmed Gamal Eissa, Raghda El Sayed Abdel Monem Galal, Nashwa El-khazragy, Shaimaa Abdelmalik Pessar
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Canonical wingless-type (Wnt) signaling is a crucial pathway involved in normal hematopoiesis and the self-renewal process of hematopoietic stem cells. Deregulation of this pathway has been associated with different subtypes of le
Externí odkaz:
https://doaj.org/article/f0ebcf3047c84bcda113d47f8355d4ab
Publikováno v:
Hematology, Transfusion and Cell Therapy. 45:25-31
Background Elevated serum progranulin (PGRN) levels have been associated with a wide range of different human malignancies. However, data available on the role of PGRN in hematological malignancies are limited. Methods Measurement of the PGRN level i
Autor:
Michael R. Loken, Lisa Eidenschink Brodersen, Todd Cooper, E. Anders Kolb, Todd A. Alonzo, Jim Wang, Sarah K. Tasian, Adam J. Lamble, Laura Pardo, Soheil Meshinchi, Richard Aplenc, Lillian Sung
Publikováno v:
J Clin Oncol
PURPOSE Increased CD123 surface expression has been associated with high-risk disease characteristics in adult acute myeloid leukemia (AML), but has not been well-characterized in childhood AML. In this study, we defined CD123 expression and associat
Autor:
Zhenzhen Yang, Hu Dou, Guo Fu, Xingjuan Wang, Lan Yuan, Yi Huang, Xi Chen, Jie Yu, Ling Lu, Liming Bao, Junqin Bi
Publikováno v:
Pediatric Hematology Oncology Journal, Vol 6, Iss 4, Pp 158-165 (2021)
Background: Although monosomal karyotype (MK) has been recognized as an adverse risk factor in adult acute myeloid leukemia (AML), its impact on pediatric AML outcomes remains unclear. Methods: Clinical characteristics, cytogenetic and molecular prof
Autor:
Anthony Letai, Eleni Skourti
Publikováno v:
The FEBS Journal. 288:6087-6094
Anthony Letai is Professor in Medicine at Harvard Medical School and Dana Farber Cancer Institute, and President of The Society for Functional Precision Medicine. Among Tony's scientific achievements, work from his lab contributed toward the FDA appr
Autor:
Abdulsamad Wafa, Bassel Al-Halabi, Imad Aboukhamis, Ismael F Al-Arbeed, Walid Al-Achkar, Faten Moassass
Publikováno v:
Asian Pacific Journal of Cancer Prevention. 22:3245-3251
Objective Activating mutations of the fms-like tyrosine kinase 3 gene (FLT3) by internal tandem duplications (ITDs) in the juxtamembrane domain (JMD) have been reported in ~30% of adult acute myeloid leukemia (AML) patients with cytogenetically norma
Autor:
Xiaohui Cai, Jinfei Wang, Hongying Chao, Jianfang Liu, Jingtao Lu, Zhuxia Jia, Meiyu Chen, Xuzhang Lu
Publikováno v:
Acta Haematologica. 145:144-151
Mixed lineage leukemia (MLL) T10 is a relatively rare partner for the KMT2A lysine (K)-specific methyltransferase 2A gene. The common features and coexisting mutations of acute myeloid leukemia (AML) patients with KMT2A-MLLT10 remain unknown. In this
Autor:
Tara Cronin, Kristopher Attwood, Eunice S. Wang, Sarah Sadek, Mark G. Faber, Swapna Thota, James E. Thompson, Jeffrey Baron, Ellen Madarang, Elizabeth A. Griffiths, Justin M. Watts, Terrence Bradley, Amanda Przespolewski, Abhay Singh
Publikováno v:
Clin Lymphoma Myeloma Leuk
The optimal approach to combine gemtuzumab-ozogamicin (GO) with various chemotherapy backbones and other newer agents safely remains to be determined. We performed a retrospective analysis of the safety and outcomes of newly diagnosed adult AML patie
Autor:
Muruvvet Seda Aydin, Gülsüm Özet, Funda Ceran, Simten Dagdas, Mehmet Ali Ucar, Ahmet Kursad Gunes, Esra Cengiz
Publikováno v:
Medical Science and Discovery. 8:485-491
Objective: Myeloid growth factors have been often used in allogeneic hematopoietic stem cell transplantation settings. There are some controversies about increased graft versus host disease, relapse, and delayed platelet engraftment with those growth