Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Adrienne Verhoef"'
Publikováno v:
PLoS Medicine, Vol 2, Iss 3, p e78 (2005)
BACKGROUND: Synthetic peptides, representing CD4(+) T cell epitopes, derived from the primary sequence of allergen molecules have been used to down-regulate allergic inflammation in sensitised individuals. Treatment of allergic diseases with peptides
Externí odkaz:
https://doaj.org/article/adc097793cd8409991068992a042be80
Autor:
Corinne M. Savill, Marc Feldmann, Victor Duance, Marco Londei, Zoe A. Leech, Fionula M. Brennan, Adrienne Verhoef, Ravinder N. Maini
Rheumatoid arthritis is an autoimmune disease characterized by T-cell infiltration of the synovium of joints. Analysis of the phenotype and antigen specificity of the infiltrating cells may thus provide insight into the pathogenesis of rheumatoid art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9c0f74602f335e18c40adbf422b3a7
https://doi.org/10.1073/pnas.86.2.636
https://doi.org/10.1073/pnas.86.2.636
Autor:
Adrienne Verhoef, Bernard Maillere, Cezmi A. Akdis, M. D. Tarzi, S. Klunker, A. B. Kay, Catherine Texier, S. O. Stapel, Mark Larché
Publikováno v:
Clinical and Experimental Allergy
Clinical and Experimental Allergy, Wiley, 2006, 36 (4), pp.465-74. ⟨10.1111/j.1365-2222.2006.02469.x⟩
Clinical and Experimental Allergy, Wiley, 2006, 36 (4), pp.465-74. ⟨10.1111/j.1365-2222.2006.02469.x⟩
International audience; BACKGROUND: Allergen-derived (T cell epitope) peptides may be safer for immunotherapy than native allergen, as they do not cross-link immunoglobulin (Ig)E. However, HLA polymorphism results in multiple potential epitopes. Synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ce1884c4adc3079cf9afb5b1d65d37
https://doi.org/10.1111/j.1365-2222.2006.02469.x
https://doi.org/10.1111/j.1365-2222.2006.02469.x
Autor:
Adrienne Verhoef, Catherine M. Hawrylowicz, Jonathan R. Lamb, Alexander Faith, David F. Richards, Tak H. Lee
Publikováno v:
Clinical & Experimental Allergy. 33:1209-1215
Summary Background Allergen immunotherapy (IT) is a successful treatment associated with decreased Th2 cytokine production by allergen-specific T cells. We have previously demonstrated (Faith et al., J Immunol 1997; 159:53–57) that inhibition of Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24747d42f38154beaffc47bc005b99d4
https://doi.org/10.1046/j.1365-2222.2003.01748.x
https://doi.org/10.1046/j.1365-2222.2003.01748.x
Autor:
Adrienne Verhoef, Samantha Walker, Duncan R. Wilson, Kayhan T. Nouri-Aria, Stephen J. Till, Stephen R. Durham, Petra A. Wachholz
Publikováno v:
Immunology. 105:56-62
Grass pollen immunotherapy is the only treatment for hayfever that is both effective and confers long-term benefit. Immunotherapy may act by altering the local nasal mucosal T helper type 2 (Th2) to type 1 (Th1) cytokine balance either by down-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bab59997826e0145db68e95d49f9a5
https://doi.org/10.1046/j.1365-2567.2002.01338.x
https://doi.org/10.1046/j.1365-2567.2002.01338.x
Autor:
Paul Emery, Michael J. Francis, Xia Wu, Jonathan R. Lamb, Adrienne Verhoef, Frederique Ponchel, A.W. Boylston, Manir Ali, Douglas J. Veale, Alexander F. Markham, John D. Isaacs, Katherine E. Wilson
Publikováno v:
Journal of Clinical Investigation. 107:519-528
Rheumatoid arthritis (RA) is a chronic, inflammatory synovitis whose pathogenesis may involve autoimmune mechanisms. Anergy is a state of T-cell nonresponsiveness characterized by downregulated IL-2 production. Paradoxically, RA T cells are hyporespo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a6c4622bde8924ff0b13467e54f210
https://doi.org/10.1172/jci8027
https://doi.org/10.1172/jci8027
Autor:
Petra A. Wachholz, Stephen J. Till, Adrienne Verhoef, Christopher Corrigan, Kayhan T. Nouri-Aria, Stephen R. Durham, Eva M Varga
Publikováno v:
The Journal of Immunology. 165:2877-2885
IL-12 suppresses proallergic Th2-type cytokine production and induces Th1-type cytokine production by peripheral blood T cells from subjects with allergic disease. The objective of the present study was to examine the relevance of these findings to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e06c17415ae97f69614c05696cc990
https://doi.org/10.4049/jimmunol.165.5.2877
https://doi.org/10.4049/jimmunol.165.5.2877
Publikováno v:
Immunology. 100:209-216
Exposure to optimal peptide antigen concentrations induces human CD4+ T-cell clones to proliferate and secrete various cytokines. Higher (> 10-fold optimal) antigen concentrations cause long-term proliferative unresponsiveness, which can be reversed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af499178019eabe5dbcb8f1d6f6e3236
https://doi.org/10.1046/j.1365-2567.2000.00036.x
https://doi.org/10.1046/j.1365-2567.2000.00036.x
Autor:
Jonathan R. Lamb, Adrienne Verhoef
Publikováno v:
The Journal of Immunology. 164:6034-6040
Molecular interactions between TCR and its natural ligand, in the presence of costimulatory signals, elicit T cell effector functions, whereas subtle changes in the structure of antigenic peptides may induce only selected T cell effector function inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd62d927a1edca78b805ea8b3106ba5
https://doi.org/10.4049/jimmunol.164.11.6034
https://doi.org/10.4049/jimmunol.164.11.6034
Autor:
Adrienne, Verhoef
Publikováno v:
Methods in molecular medicine. 138
The study of monoclonal human T-cell populations has had a fundamental impact on our current knowledge of the function, specificity, and mechanisms of activation of these cells. The frequency of antigen-specific T cells in peripheral blood is low, ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9f58ecded01eac11a774aeb2e308ce1
https://pubmed.ncbi.nlm.nih.gov/18615242
https://pubmed.ncbi.nlm.nih.gov/18615242