Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Adrienne M. Gorman"'
Autor:
Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lip
Externí odkaz:
https://doaj.org/article/5880a9d0a80d435dbe79e1dfb4bc9b6f
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 13313-13322 (2018)
Externí odkaz:
https://doaj.org/article/5099dee3ae2942b2b8e275e65d5ffa99
Autor:
Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel
Externí odkaz:
https://doaj.org/article/397f4e630bac42c587fdf199a5689e3f
Autor:
Claire M. Robinson, Aaron Talty, Susan E. Logue, Katarzyna Mnich, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Cancers, Vol 13, Iss 2, p 261 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and one of the leading causes of cancer-associated deaths in the world. It is characterised by dismal response rates to conventional therapies. A major challenge in
Externí odkaz:
https://doaj.org/article/30435bdcaee345e0bc18539b5b22a1d3
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5538 (2019)
Inositol-requiring enzyme 1α (IRE1α) is a transmembrane dual kinase/ribonuclease protein involved in propagation of the unfolded protein response (UPR). Inositol-requiring enzyme 1α is currently being explored as a potential drug target due to the
Externí odkaz:
https://doaj.org/article/9ff34e13bd1d4625b85a2f936af53667
Publikováno v:
Cancers, Vol 3, Iss 1, Pp 510-530 (2011)
One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that neurotrophins contribute to
Externí odkaz:
https://doaj.org/article/d7eb8c8ecd0344a891800afc853fd8e2
Autor:
Eoghan P. McGrath, Susan E. Logue, Katarzyna Mnich, Shane Deegan, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Cancers, Vol 10, Iss 10, p 344 (2018)
In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new a
Externí odkaz:
https://doaj.org/article/ab88479294b544bdbaf463692c6eef3a
Publikováno v:
International Journal of Cell Biology, Vol 2010 (2010)
Externí odkaz:
https://doaj.org/article/3be467be03fa4f4eb8d41897b4b0aa8c
Publikováno v:
International Journal of Cell Biology, Vol 2010 (2010)
6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease. Here, we investigated the effects of the endogenous cannabinoid, anandamide, on 6-OHDA-indu
Externí odkaz:
https://doaj.org/article/ec1acc946a344650a164e4ffcb1591e5
Publikováno v:
International Journal of Cell Biology, Vol 2010 (2010)
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large
Externí odkaz:
https://doaj.org/article/77e5fa1c812e47c08de13962e79513d5