Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Adrienne Lepp"'
Autor:
Xiaomei Qi, Songwang Hou, Matthew Mortensen, Guan Chen, Charles R. Myers, Adrienne Lepp, Ning Yin, Yongsheng Ji
Publikováno v:
Journal of Biological Chemistry. 292:15070-15079
Mutations in K-Ras and epidermal growth factor receptor (EGFR) are mutually exclusive, but it is not known how K-Ras activation inactivates EGFR, leading to resistance of cancer cells to anti-EGFR therapy. Here, we report that the K-Ras effector p38
Autor:
Weiqing Jing, Xiaomei Qi, Bryon D. Johnson, Jun Tang, Michael B. Dwinell, Christopher R. Chitambar, Guan Chen, Shao Ma, Ning Yin, Adrienne Lepp
Publikováno v:
Stem Cells. 33:2738-2747
Triple-negative breast cancer (TNBC) is highly progressive and lacks established therapeutic targets. p38γ mitogen-activated protein kinase (MAPK) (gene name: MAPK12) is overexpressed in TNBC but how overexpressed p38γ contributes to TNBC remains u
Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer
Autor:
Lei Dong, Susan Tsai, Ning Yin, Shixiu Wu, Songwang Hou, Zainab Basir, Congying Xie, Aniko Szabo, Gang Li, Guan Chen, Xiaomei Qi, Marla A. Chesnik, Shama P. Mirza, Adrienne Lepp
Publikováno v:
Oncotarget
A cancer phenotype is driven by several proteins and targeting a cluster of functionally interdependent molecules should be more effective for therapeutic intervention. This is specifically important for Ras-dependent cancer, as mutated (MT) Ras is n
Publikováno v:
Journal of Biological Chemistry. 287:27895-27905
Phosphatase plays a crucial role in determining cellular fate by inactivating its substrate kinase, but it is not known whether a kinase can vice versa phosphorylate its phosphatase to execute this function. Protein-tyrosine phosphatase H1 (PTPH1) is
Autor:
A. Ligon Perrow, Darryl C. Zeldin, Adrienne Lepp, Craig R. Lee, Fred B. Lih, James A. Clark, Joan P. Graves, Kenneth B. Tomer, J. Alyce Bradbury, John D. Imig, M. Alison Kannon, Nabil J. Alkayed, Matthew L. Edin, Julie F. Foley, Laura M. DeGraff, Oline K. Rønnekleiv, John R. Falck, Page Myers
Publikováno v:
The FASEB Journal. 24:3770-3781
Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate sodium transport and blood pressure. Although endothelial CYP-derived EETs are potent vasodilators, their contribution to the regulation of blood pressure remains unclear.
Autor:
Phillip Wang, Guan Chen, Zainab Basir, Charles R. Myers, Xiaomei Qi, Christopher R. Chitambar, Huiying Zhi, Jian Huang, Adrienne Lepp
Publikováno v:
The Journal of biological chemistry. 287(18)
Estrogen receptor (ER) α promotes breast cancer growth by regulating gene expression through classical estrogen response element (ERE) binding and nonclassical (interaction with c-Jun at AP-1 sites) pathways. ER is the target for anti-estrogens such
Cancer drugs suppress tumor cell growth by inhibiting specific cellular targets. However, most drugs also activate several cellular nonspecific stress pathways, and the implications of these off-target effects are mostly unknown. Here, we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35415d6a4ff019c9a46db2f52870711
https://europepmc.org/articles/PMC3195563/
https://europepmc.org/articles/PMC3195563/
Publikováno v:
AfCS-Nature Molecule Pages.