Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Adrienne K. Scott"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function within changing cellular environments. Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress
Externí odkaz:
https://doaj.org/article/01710117b99c4759afd0cb3f49868285
Autor:
Soham Ghosh, Benjamin Seelbinder, Jonathan T. Henderson, Ryan D. Watts, Adrienne K. Scott, Alexander I. Veress, Corey P. Neu
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1607-1620.e4 (2019)
Summary: Structural heterogeneity is a hallmark of living cells that drives local mechanical properties and dynamic cellular responses. However, the robust quantification of intracellular mechanics is lacking from conventional methods. Here, we descr
Externí odkaz:
https://doaj.org/article/1c231d10b10f4aceb80907dfab44df65
Autor:
Stephanie E. Schneider, Adrienne K. Scott, Benjamin Seelbinder, Courtney Van Den Elzen, Robert L. Wilson, Emily Y. Miller, Quinn I. Beato, Soham Ghosh, Jeanne E. Barthold, Jason Bilyeu, Nancy C. Emery, David M. Pierce, Corey P. Neu
Publikováno v:
Acta Biomaterialia. 163:339-350
Cells are continuously exposed to dynamic environmental cues that influence their behavior. Mechanical cues can influence cellular and genomic architecture, gene expression, and intranuclear mechanics, providing evidence of mechanosensing by the nucl
Autor:
Adrienne K. Scott, Eduard Casas, Stephanie E. Schneider, Alison R. Swearingen, Courtney L. Van Den Elzen, Benjamin Seelbinder, Jeanne E. Barthold, Jennifer F. Kugel, Josh Lewis Stern, Kyla J. Foster, Nancy C. Emery, Justin Brumbaugh, Corey P. Neu
Publikováno v:
Biophysical Journal. 122:1428-1444
Autor:
Corey P. Neu, Soham Ghosh, Jonathan T. Henderson, Adrienne K. Scott, Jeanne E. Barthold, Stephanie E. Schneider, Samantha Kaonis, Benjamin Seelbinder, Brittany M. St. Martin
Publikováno v:
Biophys J
The biophysical features of a cell can provide global insights into diverse molecular changes, especially in processes like the dedifferentiation of chondrocytes. Key biophysical markers of chondrocyte dedifferentiation include flattened cellular mor
Expansion of chondrocytes presents a major obstacle in the cartilage regeneration procedure matrix-induced autologous chondrocyte implantation (MACI). Dedifferentiation of chondrocytes during the expansion process leads to the emergence of a fibrotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6609356e3e8f443ecc816416e80ec152
https://doi.org/10.1101/2022.10.23.513439
https://doi.org/10.1101/2022.10.23.513439
Autor:
Adrienne K. Scott, Eduard Casas, Stephanie E. Schneider, Alison R. Swearingen, Courtney L. Van Den Elzen, Benjamin Seelbinder, Jeanne E. Barthold, Jennifer F. Kugel, Josh Lewis Stern, Kyla J. Foster, Nancy C. Emery, Justin Brumbaugh, Corey P. Neu
Understanding how cells remember previous mechanical environments to influence their fate, or mechanical memory, informs the design of biomaterials and therapies in medicine. Current regeneration therapies require two-dimensional (2D) cell expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d16e9a478b2330ab5551079718aefe4
https://doi.org/10.1101/2021.12.14.472696
https://doi.org/10.1101/2021.12.14.472696
Autor:
Benjamin Seelbinder, Eduard Casas, Adrienne K. Scott, Soham Ghosh, Stephanie E. Schneider, Corey P. Neu, Alycia G. Berman, Sarah Calve, Alison R. Swearingen, Kenneth B. Margulies, Craig J. Goergen, Kenneth Bedi, Justin Brumbaugh
Publikováno v:
Nat Biomed Eng
In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix are associated with cellular de-differentiation and with subsequent functional declines. However, the underlying mechanoreceptive mechanisms are largely uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e455ab24d354dfbc5f1e1a76d5f795
https://europepmc.org/articles/PMC9300284/
https://europepmc.org/articles/PMC9300284/
Autor:
Isabel Nelson, Stephanie E. Schneider, Corey P. Neu, Adrienne K. Scott, Benjamin Seelbinder, Kristin N. Calahan
Publikováno v:
Biophys J
Mechanisms of cellular and nuclear mechanosensation are unclear, partially because of a lack of methods that can reveal dynamic processes. Here, we present a new concept for a low-cost, three-dimensionally printed device that enables high-magnificati
Autor:
Kevin N. Eckstein, Stacey M. Thomas, Adrienne K. Scott, Corey P. Neu, Nancy A. Hadley-Miller, Karin A. Payne, Virginia L. Ferguson
Publikováno v:
J Mech Behav Biomed Mater
The growth plate is a cartilaginous tissue that functions to lengthen bones in children. When fractured, however, the growth plate can lose this critical function. Our understanding of growth plate fracture and mechanobiology is currently hindered by