Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Adrienne A. Tymiak"'
Autor:
Adrienne A. Tymiak, Richard Y.-C. Huang, John T Mehl, Guodong Chen, Camelia Chiriac, Peter Sabbatini, Yan Zhang, Jia Duo, Renuka Pillutla
Publikováno v:
Analytical Chemistry. 90:5162-5170
Accurate quantification of soluble glypican-3 in clinical samples using immunoassays is challenging, because of the lack of appropriate antibody reagents to provide a full spectrum measurement of all potential soluble glypican-3 fragments in vivo. Gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7e72b2e7adb1023991d5fda51b134d
https://doi.org/10.1021/acs.analchem.7b05277
https://doi.org/10.1021/acs.analchem.7b05277
Autor:
Adrienne A. Tymiak, Richard Y.-C. Huang, Roxana E. Iacob, Guodong Chen, Li Tao, Ling Yang, Sethu Sankaranarayanan, Michael K. Ahlijanian
Publikováno v:
Journal of the American Society for Mass Spectrometry. 29:174-182
Fibrillization of the microtubule-associated protein tau has been recognized as one of the signature pathologies of the nervous system in Alzheimer's disease, progressive supranuclear palsy, and other tauopathies. The conformational transition of tau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cec7f1eed7f934a2e8131f14ca0c08
https://doi.org/10.1007/s13361-017-1815-8
https://doi.org/10.1007/s13361-017-1815-8
Autor:
Adrienne A. Tymiak, Mary T. Obermeier, Jun Dai, Yingru Zhang, Chunlei Wang, Lorell Discenza, Sarah C. Traeger
Publikováno v:
Journal of Chromatography A. 1487:116-128
Atropisomers are stereoisomers resulting from hindered bond rotation. From synthesis of pure atropisomers, characterization of their interconversion thermodynamics to investigation of biological stereoselectivity, the evaluation of drug candidates su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d94ade29ea0a9bc1dc4b7961d523b2
https://doi.org/10.1016/j.chroma.2017.01.016
https://doi.org/10.1016/j.chroma.2017.01.016
Autor:
Brenda Stevens, Derek Bond, Hui Wei, Ty M. Brender, Susan H. Julien, Michael L. Gross, Jena Feiner, Johanna Harshman, Richard Y.-C. Huang, Guodong Chen, Nels Hamacher, Luciano Mueller, Lumelle A. Schneeweis, Preeti Sejwal, Jing Li, Stanley R. Krystek, Kristina Moore, Adrienne A. Tymiak, Daniel Cohen, Zheng Lin, Paul O. Sheppard, Claire Noriega
Publikováno v:
Analytical Chemistry. 89:2250-2258
Epitope mapping the specific residues of an antibody/antigen interaction can be used to support mechanistic interpretation, antibody optimization, and epitope novelty assessment. Thus, there is a strong need for mapping methods, particularly integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9114ca37113e0a61837a1b73a850d46
https://doi.org/10.1021/acs.analchem.6b03058
https://doi.org/10.1021/acs.analchem.6b03058
Autor:
Adrienne A. Tymiak, Sike Chen, Richard Y.-C. Huang, Chunlei Wang, Janet Caceres-Cortes, Yingru Zhang
Publikováno v:
Journal of Chromatography A. 1455:133-139
UV spectrophotometry is widely used to determine the molar extinction coefficients (MECs) of cytotoxic drugs as well as the drug antibody ratios (DARs) of antibody drug conjugates (ADCs). However, the unknown purity of a drug due to interfering impur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41497c08ec72967a88b928871e06a309
https://doi.org/10.1016/j.chroma.2016.05.086
https://doi.org/10.1016/j.chroma.2016.05.086
Autor:
Alexander T. Kozhich, Malavi Madireddi, Zhen Lou, Adrienne A. Tymiak, Yongxin Zhu, Celia D’Arienzo, Anjaneya Chimalakonda, Timothy V Olah
Publikováno v:
Bioanalysis. 8:193-204
Background: Therapeutic protein discovery study highlights the need for the development of quantitative bioanalytical methods for determining the levels of both the therapeutic protein and the target protein, as well. Results: For the quantitation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc84c51b4b6e3dedf24499249a2bfcce
https://doi.org/10.4155/bio.15.238
https://doi.org/10.4155/bio.15.238
Autor:
Adrienne A. Tymiak, Sike Chen, Chunlei Wang, Aaron P. Yamniuk, Yingru Zhang, John A. Brailsford
Publikováno v:
Journal of Chromatography A. 1426:133-139
Two dimensional liquid chromatography (2D-LC) coupling size exclusion (SEC) and hydrophilic interaction chromatography (HILIC) is demonstrated as a useful tool to study polar excipients, such as histidine and its degradant, in protein formulation sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1aaf78d5ae43d56db70bee5ed2b5ef
https://doi.org/10.1016/j.chroma.2015.11.065
https://doi.org/10.1016/j.chroma.2015.11.065
Autor:
Animesh Goswami, Feng Qiu, Carl P. Decicco, Andrew T. Pudzianowski, Quentin Michaudel, Adrienne A. Tymiak, Patrick Y.S. Lam, Samuel J. Bonacorsi, Yingru Zhang, Benjamin P. Vokits, Bei Wang, Brad D. Maxwell, Bang-Chi Chen, Ronald L. Hanson, Jun Dai, Arvind Mathur, Dauh-Rurng Wu, Scott A. Shaw, W. Griffith Humphreys, Shun Su, Phil S. Baran, Janet Caceres Cortes, Balu Balasubramanian, Ruth R. Wexler, Zhiwei Guo, Rulin Zhao, Dawn Sun, Wenying Li, Li Peng, Kevin Cao
Publikováno v:
The Journal of Organic Chemistry. 80:7019-7032
Clopidogrel is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y12 and thus inhibit platelet activation. However, gaining an understanding of patient response has been limited due to imprecise und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c53ac4952f4eca4144d5c86041f3bba
https://doi.org/10.1021/acs.joc.5b00632
https://doi.org/10.1021/acs.joc.5b00632
Autor:
Michael L. Doyle, Roxana E. Iacob, Richard Y.-C. Huang, Guodong Chen, Paul E. Morin, Hui Wei, Li Tao, Zheng Lin, Stanley R. Krystek, John R. Engen, Adrienne A. Tymiak
Publikováno v:
Expert Review of Proteomics. 12:159-169
Interleukin-23 (IL-23) is an important therapeutic target for the treatment of inflammatory diseases. Adnectins are targeted protein therapeutics that are derived from domain III of human fibronectin, and have similar protein scaffold to antibodies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab8ec344416d18251086e736f1a632b
https://doi.org/10.1586/14789450.2015.1018897
https://doi.org/10.1586/14789450.2015.1018897
Autor:
Michael L. Gross, Ekaterina G. Deyanova, Jingjie Mo, Steve R. O’Neil, Richard Y.-C. Huang, Adrienne A. Tymiak, Ke Sherry Li, Brett R. Beno, Guodong Chen
Publikováno v:
Analytical chemistry. 89(14)
Higher order structure (HOS) is a crucial determinant for the biological functions and quality attributes of protein therapeutics. Mass spectrometry (MS)-based protein footprinting approaches play an important role in elucidating the relationship bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a7a3acb24c83f06af6ed3a282318cb
https://pubmed.ncbi.nlm.nih.gov/28621526
https://pubmed.ncbi.nlm.nih.gov/28621526