Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Adrien eMoreau"'
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Voltage gated sodium channels (Nav) are transmembrane proteins responsible for action potential initiation. Mutations mainly located in the voltage sensor domain (VSD) of Nav1.5, the cardiac sodium channel, have been associated with the development o
Externí odkaz:
https://doaj.org/article/455df5995d094f79a3d6ff5ccb195dd7
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Voltage sensor domain (VSDs) are a feature of voltage gated ion channel (VGICs) and voltage sensitive proteins. They are composed of four transmembrane (TM) segments (S1 to S4). Currents leaking through VSDs are called omega or gating pore currents.G
Externí odkaz:
https://doaj.org/article/a0a151211d2a481896c49af37809d312
Autor:
Adrien eMoreau, Andrew D Krahn, Pascal eGosselin-Badaroudine, George J Klein, Georges eChristé, Yohann eVincent, Mohamed eBoutjdir, Mohamed eChahine
Publikováno v:
Frontiers in Pharmacology, Vol 4 (2013)
Long QT syndrome (LQTS) is a congenital abnormality of cardiac repolarization that manifests as a prolonged QT interval on 12-lead electrocardiograms. The syndrome may lead to syncope and sudden death from ventricular tachyarrhythmias known as torsad
Externí odkaz:
https://doaj.org/article/62719690cba44a40a218cc161ce50654
Autor:
Adrien eMoreau, Dagmar I Keller, Hai eHuang, Véronique eFressart, Christian eSchmied, Quadiri eTimour, Mohamed eChahine
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
The human cardiac sodium channel Nav1.5 encoded by the SCN5A gene plays a critical role in cardiac excitability and the propagation of action potentials. Nav1.5 dysfunctions due to mutations cause cardiac diseases such as the LQT3 form of long QT syn
Externí odkaz:
https://doaj.org/article/c58e4d10665745759e48d15a8dd16965