Micro-MRI study of cerebral aging: ex vivo detection of hippocampal subfield reorganization, microhemorrhages and amyloid plaques in mouse lemur primates.

Autor: Anne Bertrand, Adrien Pasquier, Alexandra Petiet, Christopher Wiggins, Audrey Kraska, Nelly Joseph-Mathurin, Fabienne Aujard, Nadine Mestre-Francés, Marc Dhenain

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56593 (2013)

Mouse lemurs are non-human primate models of cerebral aging and neurodegeneration. Much smaller than other primates, they recapitulate numerous features of human brain aging, including progressive cerebral atrophy and correlation between regional atr

Externí odkaz: https://doaj.org/article/1c608f09251f48288e7f34e329581b88

Lysosomes in nutrient signalling: A focus on pancreatic β-cells

Autor: Adrien Pasquier, Alexander Goginashvili, Kevin Vivot, Gergő Mészáros, Romeo Ricci

Publikováno v: Diabetes, obesitymetabolism. 20

Regulated insulin secretion from pancreatic β-cells is a major process maintaining glucose homeostasis in mammals. Enhancing insulin release in response to chronic nutrient overload and obesity-related insulin resistance (pre-diabetes) requires seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9deb492d319519d9c7f6ba883a0d5712
https://pubmed.ncbi.nlm.nih.gov/30230186

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Autor: Zhirong, Zhang, Gergö, Meszaros, Wan-Ting, He, Yanfang, Xu, Helena, de Fatima Magliarelli, Laurent, Mailly, Michael, Mihlan, Yansheng, Liu, Marta, Puig Gámez, Alexander, Goginashvili, Adrien, Pasquier, Olga, Bielska, Bénédicte, Neven, Pierre, Quartier, Rudolf, Aebersold, Thomas F, Baumert, Philippe, Georgel, Jiahuai, Han, Romeo, Ricci

Publikováno v: The Journal of Experimental Medicine

Zhang et al. show that Golgi-mediated protein kinase D (PKD) signaling is required and sufficient for NLRP3 inflammasome activation. PKD at the Golgi phosphorylates NLRP3 to release it from mitochondria-associated endoplasmic reticulum membranes, all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdd5f053c22872a5d4a8ac13d557ebef
https://pubmed.ncbi.nlm.nih.gov/28716882

Insulin secretory granules control autophagy in pancreatic cells

Autor: Pascal Kessler, Carmine Settembre, Izabela Sumara, Michael Mihlan, Eric Erbs, Laura Cinque, Alexander Goginashvili, Yannick Schwab, Joëlle Morvan, Romeo Ricci, Coralie Spiegelhalter, Adrien Pasquier, Zhirong Zhang, Nicole L. Schieber, Ksenia Krupina

Publikováno v: Science
Science, American Association for the Advancement of Science, 2015, 347 (6224), pp.878-882. ⟨10.1126/science.aaa2628⟩

Pancreatic β cells lower insulin release in response to nutrient depletion. The question of whether starved β cells induce macroautophagy, a predominant mechanism maintaining energy homeostasis, remains poorly explored. We found that, in contrast t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c6ebff630836e78785c98e0c372280
https://hal.archives-ouvertes.fr/hal-03080550

Impact of snowmelt on the population structure of the plant pathogen Pseudomonas syringae in an alpine hydrological system

Autor: Caroline MONTEIL, Catherine Glaux, Caroline Guilbaud, Adrien Pasquier, Francois Lafolie, Morris, Cindy E.

Publikováno v: ISME13. 2010; 13. International symposium on microbial ecology, Seattle, USA, 2010-08-22-2010-08-27, 1 p.
HAL
13. International symposium on microbial ecology
13. International symposium on microbial ecology, Aug 2010, Seattle, United States

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::98831c6b4daebacad9fbaead4948c7f5
http://prodinra.inra.fr/record/33981