Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Adrien Le Thomas"'
Autor:
Fátima Cairrão, Cristiana C. Santos, Adrien Le Thomas, Scot Marsters, Avi Ashkenazi, Pedro M. Domingos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In Drosophila, ER-targeted mRNAs are degraded by Ire1-dependent pathway. Here the authors report that the fly mRNA binding protein Pumilio is phosphorylated by Ire1 and binds to Xbp1 mRNA, protecting it from the non-canonical endoribonuclease activit
Externí odkaz:
https://doaj.org/article/4136424ab196470b833fcd5fa037db28
Autor:
Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M. Harnoss, David A. Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D. Wu, Peter Walter, Avi Ashkenazi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD). Here the authors discover a more promiscuous IRE1 activity dubbed RIDD lacking endomotif (RIDDLE)
Externí odkaz:
https://doaj.org/article/bef46ea29dad4d2bbd29966c9a96665b
Autor:
Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The RNase activity of Inositol-Requiring Enzyme 1 (IRE1) can be allosterically regulated by ATP-competitive inhibitors of the IRE1 kinase domain. Here, the authors identify ATP-competitive IRE1 RNase activators with improved selectivity and cellular
Externí odkaz:
https://doaj.org/article/b949b998bea04b119070c87d6eced201
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1617-1623 (2014)
Piwi-interacting (pi)RNAs repress diverse transposable elements in germ cells of Metazoa and are essential for fertility in both invertebrates and vertebrates. The precursors of piRNAs are transcribed from distinct genomic regions, the so-called piRN
Externí odkaz:
https://doaj.org/article/601bb13b498e4664aa6bfb5e2b20e4c2
Autor:
Mor Levi-Ferber, Rewayd Shalash, Adrien Le-Thomas, Yehuda Salzberg, Maor Shurgi, Jennifer IC Benichou, Avi Ashkenazi, Sivan Henis-Korenblit
Publikováno v:
eLife, Vol 10 (2021)
Understanding the molecular events that regulate cell pluripotency versus acquisition of differentiated somatic cell fate is fundamentally important. Studies in Caenorhabditis elegans demonstrate that knockout of the germline-specific translation rep
Externí odkaz:
https://doaj.org/article/774bac0ce2bc43779926e170e459fba1
Autor:
Avi Ashkenazi, Peter Walter, Hartmut Koeppen, Joachim Rudolph, Zora Modrusan, Margaret Solon, Monika Dohse, Kathryn Mesh, Lisa M. Crocker, Klara Totpal, Mark Merchant, Ehud Segal, David Kan, David A. Lawrence, Anna Shemorry, Scot A. Marsters, Thomas D. Wu, Ofer Guttman, Mike Reichelt, Adrien Le Thomas, Jonathan M. Harnoss
Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stress caused by cellular oncogene activation and a hostile tumor microenvironment (TME). The key UPR sensor IRE1α resides in the ER and deploys a cytopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f449b5b365bd1638a42e0af1a7c7a357
https://doi.org/10.1158/0008-5472.c.6511463.v1
https://doi.org/10.1158/0008-5472.c.6511463.v1
Autor:
Avi Ashkenazi, Peter Walter, Hartmut Koeppen, Joachim Rudolph, Zora Modrusan, Margaret Solon, Monika Dohse, Kathryn Mesh, Lisa M. Crocker, Klara Totpal, Mark Merchant, Ehud Segal, David Kan, David A. Lawrence, Anna Shemorry, Scot A. Marsters, Thomas D. Wu, Ofer Guttman, Mike Reichelt, Adrien Le Thomas, Jonathan M. Harnoss
Supplementary Data, including Supplementary Materials and Methods, References for Supplementary Data, and Figs. S1 to S5 including Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2debaf8226a89d41e2b51ea1e40f553d
https://doi.org/10.1158/0008-5472.22423295
https://doi.org/10.1158/0008-5472.22423295
Autor:
Breanna Canter, Benjamin T. Walters, Alfred Lammens, Peter Liu, Avi Ashkenazi, Wilson Phung, Weiru Wang, Kevin R Clark, Adrien Le Thomas, Joachim Rudolph, Heidi J.A. Wallweber, Elena Ferri, Eric S. Day, Kyle Mortara, Maureen Beresini, Marie-Gabrielle Braun, Yung-Chia A. Chen, Susan Kaufman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Inositol-Requiring Enzyme 1 (IRE1) is an essential component of the Unfolded Protein Response. IRE1 spans the endoplasmic reticulum membrane, comprising a sensory lumenal domain, and tandem kinase and endoribonuclease (RNase) cytoplasmic domains. Exc
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Autor:
Ofer Guttman, Adrien Le Thomas, Scot Marsters, David A. Lawrence, Lauren Gutgesell, Iratxe Zuazo-Gaztelu, Jonathan M. Harnoss, Simone M. Haag, Aditya Murthy, Geraldine Strasser, Zora Modrusan, Thomas Wu, Ira Mellman, Avi Ashkenazi
Publikováno v:
The Journal of cell biology. 221(6)
Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8+ T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER), bind to major histocompatibility type I (MH
Autor:
Sivan Henis-Korenblit, Rewayd Shalash, Jennifer I. C. Benichou, Mor Levi-Ferber, Maor Shurgi, Yehuda Salzberg, Avi Ashkenazi, Adrien Le-Thomas
Publikováno v:
eLife, Vol 10 (2021)
Understanding the molecular events that regulate cell pluripotency versus acquisition of differentiated somatic cell fate is fundamentally important. Studies in Caenorhabditis elegans demonstrate that knockout of the germline-specific translation rep