Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Adrien Léger"'
Autor:
Gwladys Gernoux, Mickaël Guilbaud, Marie Devaux, Malo Journou, Virginie Pichard, Nicolas Jaulin, Adrien Léger, Johanne Le Duff, Jack-Yves Deschamps, Caroline Le Guiner, Philippe Moullier, Yan Cherel, Oumeya Adjali
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 660-674 (2021)
Adeno-associated virus (AAV) vectors are considered efficient vectors for gene transfer, as illustrated by recent successful clinical trials targeting retinal or neurodegenerative disorders. However, limitations as host immune responses to AAV capsid
Externí odkaz:
https://doaj.org/article/38d74ee6093e4b7fa86f324ccc982a8e
Autor:
Claire Domenger, Marine Allais, Virginie François, Adrien Léger, Emilie Lecomte, Marie Montus, Laurent Servais, Thomas Voit, Philippe Moullier, Yann Audic, Caroline Le Guiner
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 277-291 (2018)
Non-coding uridine-rich small nuclear RNAs (UsnRNAs) have emerged in recent years as effective tools for exon skipping for the treatment of Duchenne muscular dystrophy (DMD), a degenerative muscular genetic disorder. We recently showed the high capac
Externí odkaz:
https://doaj.org/article/b56772ff2df9496ca4c2cf486504309a
Autor:
Adrien Savy, Minna U Kaikkonen, Adrien Léger, Yohann Dickx, Lionel Galibert, Otto-Wilhelm Merten
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199866 (2018)
The human Adeno-Associated Virus serotype 2 (wtAAV2) is a common non-pathological virus and its recombinant form (rAAV) is widely used as gene therapy vector. Although rAAVs are routinely produced in the Baculovirus/Sf9 cell system, wtAAV2 has never
Externí odkaz:
https://doaj.org/article/b8e1cb9584bf4ab098e58d05e3885947
Autor:
Emilie Lecomte, Benoît Tournaire, Benjamin Cogné, Jean-Baptiste Dupont, Pierre Lindenbaum, Mélanie Martin-Fontaine, Frédéric Broucque, Cécile Robin, Matthias Hebben, Otto-Wilhelm Merten, Véronique Blouin, Achille François, Richard Redon, Philippe Moullier, Adrien Léger
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
Recent successful clinical trials with recombinant adeno-associated viral vectors (rAAVs) have led to a renewed interest in gene therapy. However, despite extensive developments to improve vector-manufacturing processes, undesirable DNA contaminants
Externí odkaz:
https://doaj.org/article/741f46340a074fda945084019638521d
Autor:
Jean-Baptiste Dupont, Benoit Tournaire, Christophe Georger, Béatrice Marolleau, Laurence Jeanson-Leh, Mireille Ledevin, Pierre Lindenbaum, Emilie Lecomte, Benjamin Cogné, Laurence Dubreil, Thibaut Larcher, Bernard Gjata, Laetitia Van Wittenberghe, Caroline Le Guiner, Magalie Penaud-Budloo, Richard O Snyder, Philippe Moullier, Adrien Léger
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Preclinical gene therapy strategies using recombinant adeno-associated virus (AAV) vectors in animal models of Duchenne muscular dystrophy have shown dramatic phenotype improvements, but long-lasting efficacy remains questionable. It is believed that
Externí odkaz:
https://doaj.org/article/846a902b7ddb4553bb393762ce9f0d6f
Autor:
Adrien Léger, Caroline Le Guiner, Michael L Nickerson, Kate McGee Im, Nicolas Ferry, Philippe Moullier, Richard O Snyder, Magalie Penaud-Budloo
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20881 (2011)
Recombinant adeno-associated viral (rAAV) vectors can support long-term transgene expression in quiescent tissues. Intramuscular (i.m.) administration of a single-stranded AAV vector (ssAAV) in the nonhuman primate (NHP) results in a peak protein lev
Externí odkaz:
https://doaj.org/article/dce465869f324f5f90b1718ab716eb4b
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract We present pycoMeth, a toolbox to store, manage and analyze DNA methylation calls from long-read sequencing data obtained using the Oxford Nanopore Technologies sequencing platform. Building on a novel, rapid-access, read-level and reference
Externí odkaz:
https://doaj.org/article/b4bcf376ccee459f95c448110f1125aa
Autor:
Adrien Leger, Ian Brettell, Jack Monahan, Carl Barton, Nadeshda Wolf, Natalja Kusminski, Cathrin Herder, Narendar Aadepu, Clara Becker, Jakob Gierten, Omar T. Hammouda, Eva Hasel, Colin Lischik, Katharina Lust, Natalia Sokolova, Risa Suzuki, Tinatini Tavhelidse, Thomas Thumberger, Erika Tsingos, Philip Watson, Bettina Welz, Kiyoshi Naruse, Felix Loosli, Joachim Wittbrodt, Ewan Birney, Tomas Fitzgerald
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background The teleost medaka (Oryzias latipes) is a well-established vertebrate model system, with a long history of genetic research, and multiple high-quality reference genomes available for several inbred strains. Medaka has a high toler
Externí odkaz:
https://doaj.org/article/6baa6b6529624872855129b4dacdee87
Autor:
Tomas Fitzgerald, Ian Brettell, Adrien Leger, Nadeshda Wolf, Natalja Kusminski, Jack Monahan, Carl Barton, Cathrin Herder, Narendar Aadepu, Jakob Gierten, Clara Becker, Omar T. Hammouda, Eva Hasel, Colin Lischik, Katharina Lust, Natalia Sokolova, Risa Suzuki, Erika Tsingos, Tinatini Tavhelidse, Thomas Thumberger, Philip Watson, Bettina Welz, Nadia Khouja, Kiyoshi Naruse, Ewan Birney, Joachim Wittbrodt, Felix Loosli
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-32 (2022)
Abstract Background Unraveling the relationship between genetic variation and phenotypic traits remains a fundamental challenge in biology. Mapping variants underlying complex traits while controlling for confounding environmental factors is often pr
Externí odkaz:
https://doaj.org/article/63ed79c9a26844949500ec619ea7c20a
Autor:
Adrien Leger, Paulo P. Amaral, Luca Pandolfini, Charlotte Capitanchik, Federica Capraro, Valentina Miano, Valentina Migliori, Patrick Toolan-Kerr, Theodora Sideri, Anton J. Enright, Konstantinos Tzelepis, Folkert J. van Werven, Nicholas M. Luscombe, Isaia Barbieri, Jernej Ule, Tomas Fitzgerald, Ewan Birney, Tommaso Leonardi, Tony Kouzarides
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data
Externí odkaz:
https://doaj.org/article/b763993df55a44c68f28be519d53614f