Analysis of the Targets and Glycosylation of Monoclonal IgAs From MGUS and Myeloma Patients

Autor: Adrien Bosseboeuf, Célia Seillier, Nicolas Mennesson, Sophie Allain-Maillet, Maeva Fourny, Anne Tallet, Eric Piver, Philippe Lehours, Francis Mégraud, Laureline Berthelot, Jean Harb, Edith Bigot-Corbel, Sylvie Hermouet

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Previous studies showed that monoclonal immunoglobulins G (IgGs) of “monoclonal gammopathy of undetermined significance” (MGUS) and myeloma were hyposialylated, thus presumably pro-inflammatory, and for about half of patients, the target of the m

Externí odkaz: https://doaj.org/article/a49bad8477a348f983a830eb11815f09

Pro-inflammatory State in Monoclonal Gammopathy of Undetermined Significance and in Multiple Myeloma Is Characterized by Low Sialylation of Pathogen-Specific and Other Monoclonal Immunoglobulins

Autor: Adrien Bosseboeuf, Sophie Allain-Maillet, Nicolas Mennesson, Anne Tallet, Cédric Rossi, Laurent Garderet, Denis Caillot, Philippe Moreau, Eric Piver, François Girodon, Hélène Perreault, Sophie Brouard, Arnaud Nicot, Edith Bigot-Corbel, Sylvie Hermouet, Jean Harb

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by th

Externí odkaz: https://doaj.org/article/0ba3d12163654fd4a6bb0491adb170f7

Tracking Plasmacytoid Dendritic Cell Response to Physical Contact with Infected Cells

Autor: Margarida Sá Ribeiro, Garima Joshi, Elodie Décembre, Célia Nuovo, Adrien Bosseboeuf, Alicia Bellomo, Manon Venet, Sonia Assil, Marlène Dreux

Publikováno v: Methods in Molecular Biology ISBN: 9781071629376

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a68cfab4d2978603020a088ecbcabdb5
https://doi.org/10.1007/978-1-0716-2938-3_21

Anti-Glucosylsphingosine Autoimmunity, JAK2V617F-Dependent Interleukin-1β and JAK2V617F-Independent Cytokines in Myeloproliferative Neoplasms

Autor: Edith Bigot-Corbel, Cédric Cleyrat, Eun Ho Eunice Choi, Laura Dufeu, Jean-Marc Gombert, François Girodon, Sophie Allain-Maillet, Nicolas Mennesson, Adrien Bosseboeuf, Yannick Le Bris, Olivier Mansier, Eric Lippert, Magali Pettazzoni, Sylvie Hermouet, Mégane Bostoën

Publikováno v: Cancers
Cancers, MDPI, 2020, 12 (9), pp.E2446. ⟨10.3390/cancers12092446⟩
Cancers, 2020, 12 (9), pp.E2446. ⟨10.3390/cancers12092446⟩
Cancers, Vol 12, Iss 2446, p 2446 (2020)
Volume 12
Issue 9

Inflammatory cytokines play a major role in myeloproliferative neoplasms (MPNs) as regulators of the MPN clone and as mediators of clinical symptoms and complications. Firstly, we investigated the effect of JAK2V617F on 42 molecules linked to inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7809f8c9ddf86ce1f6dca09a3c5ee978
https://pubmed.ncbi.nlm.nih.gov/32872203

Absolute Quantitation of Glycoforms of Two Human IgG Subclasses Using Synthetic Fc Peptides and Glycopeptides

Autor: Adrien Bosseboeuf, Emy Komatsu, Ronald Domalaon, Sylvie Hermouet, Oleg V. Krokhin, Jean Harb, Evelyn Ang, Frank Schweizer, Rini Roy, Hélène Perreault

Publikováno v: Journal of The American Society for Mass Spectrometry
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2018, Epub ahead of print. ⟨10.1007/s13361-018-1900-7⟩
Journal of The American Society for Mass Spectrometry, 2018, Epub ahead of print. ⟨10.1007/s13361-018-1900-7⟩

International audience; Immunoglobulins, such as immunoglobulin G (IgG), are of prime importance in the immune system. Polyclonal human IgG comprises four subclasses, of which IgG1 and IgG2 are the most abundant in healthy individuals. In an effort t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebece0c6ea73d62d46b48f18b58583d5
https://www.hal.inserm.fr/inserm-01806658