Výsledky vyhledávání - "Adriele da Silva Araújo"

Multigram-scale Synthesis of Building Block Nitro-imine Derivative by Using Classical Method and Ultrasound Irradiation and Conversion to Imino-alcohol Derivative, Using Camphor as Starting Material

Autor: Emerson Teixeira da Silva, Adriele da Silva Araújo, Adriana Marques Moraes, Marcus V. N. de Souza

Publikováno v: Letters in Organic Chemistry. 17:165-169

This study describes a simple multigram-scale procedure for the preparation of (E)-N-(1,7,7- trimethylbicyclo[2.2.1]heptan-2-ylidene)nitramide, nitro-imine 2, by using both classical methods and ultrasound irradiation from 1 utilizing Camphor, a natu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d19f5a132a59881147e44fceb11b8ad7
https://doi.org/10.2174/1570178616666190123114922

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2,8-bis(trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine

Autor: Thiago Moreno L. Souza, Caroline S. de Freitas, Emerson Teixeira da Silva, José Cerbino Neto, Giselle Barbosa-Lima, Patrícia T. Bozza, Andressa Marttorelli, Adriana Marques Moraes, Marcus V. N. de Souza, Adriele da Silva Araújo, Yasmine Rangel Vieira

Publikováno v: European Journal of Medicinal Chemistry. 127:334-340

Zika virus (ZIKV), an arthropod-born Flavivirus, has been associated with a wide range of neurological diseases in adults, foetuses and neonates. Since no vaccine is available, repurposing of antiviral drugs currently in medical use is necessary. Mef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16748aee111d017e2b4e43164b535c2
https://doi.org/10.1016/j.ejmech.2016.12.058

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Antibacterial activity of new substituted 4-N-alkylated-2-trifluoromethyl-quinoline analogues against sensitive and resistant Mycobacterium tuberculosis strains

Autor: Gabriel Fernandes de Andrade, Emerson Teixeira da Silva, Adriele da Silva Araújo, Marcus V. N. de Souza, Maria C.S. Lourenço

Publikováno v: European Journal of Pharmaceutical Sciences. 157:105596

s Objectives The emergence of resistant strain has aggravated the tuberculosis situation in the world, running out of control and hard to fight. We evaluate forty new quinoline analogues against sensitive and resistant Mycobacterium tuberculosis (Mtb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaf888b26ddad29e4d3ed48f46b31ee
https://doi.org/10.1016/j.ejps.2020.105596

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Synthesis and Antibacterial Activity of Mefloquine-Based Analogs Against Sensitive and Resistant Mycobacterium tuberculosis Strains

Autor: Adriele da Silva Araújo, Cláudia Pessoa, Emerson Teixeira da Silva, Maria C.S. Lourenço, Adriana M Moraes, Marcus V. N. de Souza

Publikováno v: Current topics in medicinal chemistry. 19(9)

Background and Introduction:Mefloquine, a drug used to prevent and treat malaria is described possessing activity against the Mycobacterium tuberculosis (Mtb) as well as against multidrugresistant tuberculosis (MDR) and other types of bacteria. Despi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c8b85fb2cb1c2948b1eef2758079ae
https://pubmed.ncbi.nlm.nih.gov/30836914

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Synthesis and Biological Activities of Camphor Hydrazone and Imine Derivatives

Autor: Leidiane Araujo de Souza, Adriele da Silva Araújo, James L. Wardell, Solange M. S. V. Wardell, Adriana M Moraes, Emerson Teixeira da Silva, Maria C.S. Lourenço, Marcus V. N. de Souza

Publikováno v: Scientia Pharmaceutica
Volume 84
Issue 3
Pages 467-483

Both sonochemical and classical methodologies have been employed to convert camphor, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one, C9H16C=O, into a number of derivatives including hydrazones, C9H16C=N-NHAr 3, imines, C9H16C=N-R 7, and the key intermedia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a38f688d6e018d0060c787a2dd69505
http://europepmc.org/articles/PMC5064238

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Akademický článek

Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis

Autor: Reto Rufener, Dominic Ritler, Jana Zielinski, Luca Dick, Emerson Teixeira da Silva, Adriele da Silva Araujo, Deborah Elisabeth Joekel, David Czock, Christine Goepfert, Adriana Marques Moraes, Marcus Vinicius Nora de Souza, Joachim Müller, Meike Mevissen, Andrew Hemphill, Britta Lundström-Stadelmann

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 2, Pp 331-340 (2018)

The cestode E. multilocularis causes the disease alveolar echinococcosis (AE) in humans. The continuously proliferating metacestode (larval stage) of the parasite infects mostly the liver and exhibits tumor-like growth. Current chemotherapeutical tre

Externí odkaz: https://doaj.org/article/2b3f903ef08f4147bc06e659672883ea

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