Výsledky vyhledávání - "Adrianus J, Van Vught"

Akademický článek

Mechanical ventilation drives inflammation in severe viral bronchiolitis.

Autor: Marije P Hennus, Adrianus J van Vught, Mark Brabander, Frank Brus, Nicolaas J Jansen, Louis J Bont

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83035 (2013)

INTRODUCTION: Respiratory insufficiency due to severe respiratory syncytial virus (RSV) infection is the most frequent cause of paediatric intensive care unit admission in infants during the winter season. Previous studies have shown increased levels

Externí odkaz: https://doaj.org/article/22b2df131fc04824bcd5ac3dd6347ee6

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Akademický článek

Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury.

Autor: Maria A Hegeman, Marije P Hennus, Pieter M Cobelens, Annemieke Kavelaars, Nicolaas J G Jansen, Marcus J Schultz, Adrianus J van Vught, Cobi J Heijnen

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57374 (2013)

BACKGROUND: Ventilator-induced lung injury (VILI) is characterized by vascular leakage and inflammatory responses eventually leading to pulmonary dysfunction. Vascular endothelial growth factor (VEGF) has been proposed to be involved in the pathogene

Externí odkaz: https://doaj.org/article/23ad9a2e939546c2bbc726232b6fca7b

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Akademický článek

Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury.

Autor: Maria A Hegeman, Marije P Hennus, Matijs van Meurs, Pieter M Cobelens, Annemieke Kavelaars, Nicolaas J Jansen, Marcus J Schultz, Adrianus J van Vught, Grietje Molema, Cobi J Heijnen

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15653 (2010)

BackgroundLoss of integrity of the epithelial and endothelial barriers is thought to be a prominent feature of ventilator-induced lung injury (VILI). Based on its function in vascular integrity, we hypothesize that the angiopoietin (Ang)-Tie2 system

Externí odkaz: https://doaj.org/article/7f07545ec1b245ada89475e5a61b9017

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Expanding the spectrum of phenotypes associated with germline PIGA mutations

Autor: Gijs van Haaften, Edwin Cuppen, Magdalena Harakalova, Eva H. Brilstra, Frederique M. C. van Berkestijn, Hans Kristian Ploos van Amstel, Floris C. Hofstede, Mieke M. van Haelst, Saskia N. van der Crabben, Wigard P. Kloosterman, Adrianus J. van Vught

Publikováno v: American journal of medical genetics. Part A, 164(1), 29-35. Wiley-Liss Inc.
American Journal of Medical Genetics A, 164A(1), 29-35. Wiley-Liss Inc.
van der Crabben, S N, Harakalova, M, Brilstra, E H, van Berkestijn, F M C, Hofstede, F C, van Vught, A J, Cuppen, E, Kloosterman, W, Ploos van Amstel, H K, van Haaften, G & van Haelst, M M 2014, ' Expanding the spectrum of phenotypes associated with germline PIGA mutations : a child with developmental delay, accelerated linear growth, facial dysmorphisms, elevated alkaline phosphatase, and progressive CNS abnormalities ', American Journal of Medical Genetics Part A, vol. 164A, no. 1, pp. 29-35 . https://doi.org/10.1002/ajmg.a.36184

Phosphatidyl inositol glycan (PIG) enzyme subclasses are involved in distinct steps of glycosyl phosphatidyl inositol anchor protein biosynthesis. Glycolsyl phosphatidyl inositol-anchored proteins have heterogeneous functions; they can function as en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d348dc8fbcf4735758d1bf76d0e4bd5d
https://doi.org/10.1002/ajmg.a.36184

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Host response to mechanical ventilation for viral respiratory tract infection

Autor: Linde Meyaard, Jeroen L. A. Pennings, Hennie M. Hodemaekers, Adrianus J. van Vught, Debby Kruijsen, Riny Janssen, Marije P. Hennus, Louis Bont, Nicolaas J. G. Jansen

Publikováno v: European Respiratory Journal. 40:1508-1515

Respiratory syncytial virus (RSV) bronchiolitis causes severe respiratory tract infection in infants, frequently necessitating mechanical ventilatory support. However, life-saving, mechanical ventilation aggravates lung inflammation. We set up a mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c06080a060a016fafbda8e381996a1
https://doi.org/10.1183/09031936.00177111

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Life-threatening respiratory syncytial virus disease in children

Autor: Reinout A. Bem, Albert P. Bos, Adrianus J. van Vught, Marije P. Hennus

Publikováno v: Current Respiratory Medicine Reviews, 7(3), 187-195. Bentham Science Publishers B.V.

Respiratory syncytial virus (RSV) is the most common viral cause of seasonal acute respiratory tract illness in very young children worldwide. In addition, life-threatening RSV disease accounts for the most frequent cause of non- elective pediatric i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1eb74b1e81710628a6612db2055b6fa
https://doi.org/10.2174/157339811795589513

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FOXP3+CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in human

Autor: Fabiola C M Evens, Nicolaas J. G. Jansen, Sebastiaan J. Vastert, Adrianus J. van Vught, Alvin W. L. Schadenberg, Wietse Kuis, Berent J. Prakken

Publikováno v: European Journal of Immunology. 41:1132-1142

Tregs are crucial in controlling inflammation. Although the transcription factor FOXP3 is the most applicable phenotype marker of Tregs, it does not indisputably characterize suppressive function during T-cell activation in vitro. A question that rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2116093552b1f1e9da1be2c414fdf52a
https://doi.org/10.1002/eji.201040363

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Off-hours admission and mortality in two pediatric intensive care units without 24-h in-house senior staff attendance

Autor: Casper W. Bollen, Adrianus J. van Vught, Babette Peeters, Marcel J. I. J. Albers, Douwe van der Heide, Nicolaas J. G. Jansen

Publikováno v: Intensive Care Medicine
Intensive Care Medicine, 36(11), 1923-1927. SPRINGER

Purpose To compare risk-adjusted mortality of children non-electively admitted during off-hours with risk-adjusted mortality of children admitted during office hours to two pediatric intensive care units (PICUs) without 24-h in-house attendance of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343f9ad450f42ca40a189d0ff7d92c10
https://hdl.handle.net/11370/a4f3f442-da9d-4edb-8936-7a7151c7257e

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Mechanical ventilation for respiratory failure in children with severe neurological impairment: is it futile medical treatment?

Autor: Cornelis K. van der Ent, Adrianus J. van Vught, Afke H Robroch, Casper W. Bollen, Josephus P. J. van Gestel

Publikováno v: Developmental Medicine & Child Neurology. 52:483-488

AIM To assess outcome for children with severe neurological impairment receiving invasive mechanical ventilation for respiratory failure. METHOD Medical charts for all such children treated in our intensive care unit (ICU) between January 2003 and Ju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::123057a0f0e5faa34a4257622b3cacf6
https://doi.org/10.1111/j.1469-8749.2009.03582.x

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High-frequency oscillatory ventilation in severe lung haemorrhage: A case study of three centres

Autor: Dick G. Markhorst, Adrianus J. van Vught, José Ramet, Elisabeth L.I.M. Duval

Publikováno v: Respiratory Medicine CME. 2:92-98

Summary Aim To describe the safety and efficacy of HFOV as a rescue therapy for lung haemorrhage. Methods We conducted a retrospective case study of nine children. Lung haemorrhage was defined as large amounts of blood-stained effluent not attributab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee07ec9b4e62503dd7da1e515edac16
https://doi.org/10.1016/j.rmedc.2008.10.008

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