Endoplasmic reticulum stress, unfolded protein response and altered T cell differentiation in necrotizing enterocolitis.

Autor: Peng Lu, Marie-Chantal Struijs, Jiaping Mei, Janneke Witte-Bouma, Anita M Korteland-van Male, Adrianus C J M de Bruijn, Johannes B van Goudoever, Ingrid B Renes

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78491 (2013)

Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) play important roles in chronic intestinal inflammation. Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants and is c

Externí odkaz: https://doaj.org/article/56f7bcda6731420094ede9fc5efbfbb6

Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.

Autor: Nanda Burger-van Paassen, Linda M P Loonen, Janneke Witte-Bouma, Anita M Korteland-van Male, Adrianus C J M de Bruijn, Maria van der Sluis, Peng Lu, Johannes B Van Goudoever, Jerry M Wells, Jan Dekker, Isabelle Van Seuningen, Ingrid B Renes

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38798 (2012)

BACKGROUND: Mucin Muc2 is the structural component of the intestinal mucus layer. Absence of Muc2 leads to loss of this layer allowing direct bacterial-epithelial interactions. We hypothesized that absence of the mucus layer leads to increased expres

Externí odkaz: https://doaj.org/article/f2c65b3c92b742f7a4104be5afd25d40

A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization

Autor: Kit Wun Kathy Cheung, Marjolein van Borselen, Y. Simons-Oosterhuis, Bianca D van Groen, Kathleen M. Giacomini, Dick Tibboel, Saskia N. de Wildt, Edwin Spaans, Bart Smeets, Lei Zhang, Adrianus C. J. M. de Bruijn, Robert M. Verdijk, Shiew-Mei Huang, Janneke N. Samsom

Publikováno v: Clinical Pharmacology and Therapeutics, 106, 1083-1092
Clinical Pharmacology & Therapeutics, 106(5), 1083-1092. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 106, 5, pp. 1083-1092
Clinical pharmacology and therapeutics, vol 106, iss 5
Clinical Pharmacology and Therapeutics

Contains fulltext : 209000.pdf (Publisher’s version ) (Open Access) Human renal membrane transporters play key roles in the disposition of renally cleared drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human postm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cd4575f6eb787bcefdf57875ac7b6d
http://hdl.handle.net/2066/209000

Intestinal Threonine Utilization for Protein and Mucin Synthesis Is Decreased in Formula-Fed Preterm Pigs

Autor: Mette Schmidt, Patrycja J. Puiman, Barbara J. Stoll, Adrianus C. J. M. de Bruijn, Kristien Dorst, Douglas G. Burrin, Per T. Sangild, Henk Schierbeek, Johannes B. van Goudoever, Ingrid B. Renes, Mikkel Jensen, Günther Boehm

Publikováno v: Journal of Nutrition, 141, 1306-1311. American Society for Nutrition
The Journal of nutrition, 141(7), 1306-1311. American Society for Nutrition
Journal of nutrition, 141(7), 1306-1311. American Society for Nutrition
Puiman, P J, Jensen, M, Stoll, B, Renes, I B, de Bruijn, A C J M, Dorst, K, Schierbeek, H, Schmidt, M, Boehm, G, Burrin, D G, Sangild, P T & van Goudoever, J B 2011, ' Intestinal Threonine Utilization for Protein and Mucin Synthesis Is Decreased in Formula-Fed Preterm Pigs ', The Journal of nutrition, vol. 141, no. 7, pp. 1306-1311 . https://doi.org/10.3945/jn.110.135145

Threonine is an essential amino acid necessary for synthesis of intestinal (glyco)proteins such as mucin MUC2 to maintain adequate gut barrier function. In premature infants, reduced barrier function may contribute to the development of necrotizing e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9ace6554f72ed15f68ee1435bbd1d5
https://doi.org/10.3945/jn.110.135145

Small intestinal MUC2 synthesis in human preterm infants

Autor: Adrianus C. J. M. de Bruijn, Ingrid B. Renes, Maaike W. Schaart, Johannes B. van Goudoever, Dick Tibboel, Henk Schierbeek

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology, 296(5), G1085-G1090. American Physiological Society
American Journal of Physiology-Gastrointestinal and Liver Physiology, 296, G1085-G1090. American Physiological Society
American Journal of Physiology-Gastrointestinal and Liver Physiology, 296(5), G1085-G1090. AMER PHYSIOLOGICAL SOC

Schaart MW, de Bruijn ACJM, Schierbeek H, Tibboel D, Renes IB, van Goudoever JB. Small intestinal MUC2 synthesis in human preterm infants. Am J Physiol Gastrointest Liver Physiol 296: G1085-G1090, 2009. First published February 26, 2009; doi:10.1152/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075f56730cf91211bf925fd8d16fd3a4
https://doi.org/10.1152/ajpgi.90444.2008