Výsledky vyhledávání - "Adriano Flora"

Use of CRISPR/Cas9 for the Modification of the Mouse Genome

Autor: Alexander, Klimke, Steffen, Güttler, Petric, Kuballa, Simone, Janzen, Sonja, Ortmann, Adriano, Flora

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1953

The use of CRISPR/Cas9 to modify the mouse genome has gained immense interest in the past few years since it allows the direct modification of embryos, bypassing the need of labor-intensive procedures for the manipulation of embryonic stem cells. By

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf5c751c4e7d00a1bb95cd9341bbc003
https://pubmed.ncbi.nlm.nih.gov/30912024

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Use of CRISPR/Cas9 for the Modification of the Mouse Genome

Autor: Adriano Flora, Steffen Güttler, Simone Janzen, Sonja Ortmann, Alexander Klimke, Petric Kuballa

Publikováno v: Target Identification and Validation in Drug Discovery ISBN: 9781493991440

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4907abefb4e727ad412bd61b3eca9d62
https://doi.org/10.1007/978-1-4939-9145-7_13

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Exercise and Genetic Rescue of SCA1 via the Transcriptional Repressor Capicua

Autor: Yan Gao, Angela N. Carter, Hyojin Kang, Chad A. Shaw, Juan Crespo-Barreto, Harry T. Orr, Peng Yu, Caleigh Mandel-Brehm, Huda Y. Zoghbi, Adriano Flora, John D. Fryer

Publikováno v: Science. 334:690-693

Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). To determine the long-term effects of exercise, we implemented a mild exercise regimen in a mouse model of S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061dfb57c3e563f028335936ee4bbacc
https://doi.org/10.1126/science.1212673

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In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development

Autor: Tiemo J. Klisch, Liguo Wang, Huda Y. Zoghbi, Adriano Flora, Wei Li, Yuanxin Xi

Publikováno v: Proceedings of the National Academy of Sciences. 108:3288-3293

The proneural, basic helix–loop–helix transcription factor Atoh1 governs the development of numerous key neuronal subtypes, such as cerebellar granule and brainstem neurons, inner ear hair cells, and several neurons of the proprioceptive system,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8d91d1a703eca7b3dca881aefede3e
https://doi.org/10.1073/pnas.1100230108

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Math1 Is Essential for the Development of Hindbrain Neurons Critical for Perinatal Breathing

Autor: Tiemo J. Klisch, John J. Greer, Matthew F. Rose, Huda Y. Zoghbi, Adriano Flora, Kaashif A. Ahmad, Hsiao-Tuan Chao, Jun Ren

Publikováno v: Neuron. 64(3):341-354

SummaryMice lacking the proneural transcription factor Math1 (Atoh1) lack multiple neurons of the proprioceptive and arousal systems and die shortly after birth from an apparent inability to initiate respiration. We sought to determine whether Math1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0df764b73915e55023ce05f9d62bab6

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The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors

Autor: Christina Thaller, J. García, Huda Y. Zoghbi, Adriano Flora

Publikováno v: Proceedings of the National Academy of Sciences. 104:15382-15387

Proneural factors represent TCF4 causes the Pitt–Hopkins mental retardation syndrome, underscoring the important role for this protein in neural development. To investigate the functional relevance of the Math1/Tcf4 interaction in vivo , we studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada7407ad1ec15fb8ba936f3f1914fed
https://doi.org/10.1073/pnas.0707456104

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Transcription Factor PHOX2A Regulates the Human α3 Nicotinic Receptor Subunit Gene Promoter

Autor: Roberta Benfante, Simona Di Lascio, Sara Francesca Colombo, Renato Longhi, Francesco Clementi, Francesca Cargnin, Adriano Flora, Diego Fornasari

Publikováno v: Journal of Biological Chemistry. 282:13290-13302

PHOX2A is a paired-like homeodomain transcription factor that participates in specifying the autonomic nervous system. It is also involved in the transcriptional control of the noradrenergic neurotransmitter phenotype as it regulates the gene express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d363b0d6ebbc619e2bdf5f43ff27a9
https://doi.org/10.1074/jbc.m608616200

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PHOX2B Regulates Its Own Expression by a Transcriptional Auto-regulatory Mechanism

Autor: Adriano Flora, Francesco Clementi, Diego Fornasari, Simona Di Lascio, Elena Battaglioli, Renato Longhi, Francesca Cargnin

Publikováno v: Journal of Biological Chemistry. 280:37439-37448

The specification of neuronal identity is a result of interactions between the following two distinct classes of determinants: extrinsic factors that include secreted or cell membrane-associated signals in the local environment, and intrinsic factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81e9313a4b8ec01c95e241b3169dd39
https://doi.org/10.1074/jbc.m508368200

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Molecular mechanism of the aryl hydrocarbon receptor activation by the fungicide iprodione in rainbow trout (Oncorhynchus mykiss) hepatocytes

Autor: Silvia Frigerio, Enzo Chiesara, Adriano Flora, Diego Fornasari, Michela Ferraris, Laura Marabini, Helen Lucchetti, Sonia Radice

Publikováno v: Aquatic Toxicology. 72:209-220

The dicarboximide fungicide iprodione (Ip) causes oxidative damage as a result of the production of free oxygen radicals, and induces cytochrome P4501A3 (CYP1A3) in cultured rainbow trout hepatocytes. The aim of this study was to characterise some of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eec254909a39dfa6997248e5c772610
https://doi.org/10.1016/j.aquatox.2004.12.009

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N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning

Autor: Stefano Alcaro, Nica Borgese, Sara Francesca Colombo, Francesco Ortuso, Renato Longhi, Adriano Flora, Teresa Sprocati

Publikováno v: The Journal of Cell Biology
168 (2005): 735–745.
info:cnr-pdr/source/autori:Colombo S., Longhi R., Alcaro S., Ortuso F., Sprocati T., Flora A., Borgese N./titolo:N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning/doi:/rivista:/anno:2005/pagina_da:735/pagina_a:745/intervallo_pagine:735–745/volume:168
The Journal of cell biology 168 (2005): 735–745. doi:10.1083/jcb.200407082
info:cnr-pdr/source/autori:Colombo S; Longhi R; Alcaro S; Ortuso F; Sprocati T; Flora A; Borgese N/titolo:N-myristoylation determines dual targeting of mammalian NADH-cytochrome b5 reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning./doi:10.1083%2Fjcb.200407082/rivista:The Journal of cell biology/anno:2005/pagina_da:735/pagina_a:745/intervallo_pagine:735–745/volume:168

Mammalian NADH-cytochrome b(5) reductase (b5R) is an N-myristoylated protein that is dually targeted to ER and mitochondrial outer membranes. The N-linked myristate is not required for anchorage to membranes because a stretch of hydrophobic amino aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f97c50ee17ece1f4962fe1dbd6dccb
https://doi.org/10.1083/jcb.200407082

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