Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Adriano D Andricopulo"'
Autor:
Rafael Augusto Alves Ferreira, Celso de Oliveira Rezende Junior, Pablo David Grigol Martinez, Paul John Koovits, Bruna Miranda Soares, Leonardo L G Ferreira, Simone Michelan-Duarte, Rafael Consolin Chelucci, Adriano D Andricopulo, Mariana K Galuppo, Silvia R B Uliana, An Matheeussen, Guy Caljon, Louis Maes, Simon Campbell, Jadel M Kratz, Charles E Mowbray, Luiz Carlos Dias
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009196 (2021)
Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this life-threatening infection have several drawbacks such as toxicity and long treatment regimens. A li
Externí odkaz:
https://doaj.org/article/219308c5bea148d9a0c7045ba017f44b
Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani.
Autor:
Humberto E Ortega, Leonardo L G Ferreira, Weilan G P Melo, Ana Ligia L Oliveira, René F Ramos Alvarenga, Norberto P Lopes, Tim S Bugni, Adriano D Andricopulo, Mônica T Pupo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007643 (2019)
Bacterial strains isolated from attine ants showed activity against the insect specialized fungal pathogen Escovopsis and also against the human protozoan parasite Leishmania donovani. The bioassay guided fractionation of extracts from cultures of St
Externí odkaz:
https://doaj.org/article/bb8c1e768bed4db6bba3428e89f4f710
Autor:
Luma G Magalhaes, Fernando B Marques, Marina B da Fonseca, Kamilla R Rogério, Cedric S Graebin, Adriano D Andricopulo
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160842 (2016)
Microtubules play critical roles in vital cell processes, including cell growth, division, and migration. Microtubule-targeting small molecules are chemotherapeutic agents that are widely used in the treatment of cancer. Many of these compounds are s
Externí odkaz:
https://doaj.org/article/5fef3d3b39334a7bba01158b1660cf3f
Publikováno v:
Química Nova, Vol 34, Iss 10, Pp 1770-1778 (2011)
High-throughput screening (HTS) and virtual screening (VS) are useful methods employed in drug discovery, allowing the identification of promising hits for lead optimization. The efficiency of these approaches depends on a number of factors, such as
Externí odkaz:
https://doaj.org/article/0a9943e58bad4a7381c1019685f18d40
Autor:
Brian W. Slafer, Marco A. Dessoy, Ramon G. de Oliveira, Maria C. Mollo, Eun Lee, An Matheeussen, Louis Maes, Guy Caljon, Leonardo L. G. Ferreira, Renata Krogh, Adriano D. Andricopulo, Luiza R. Cruz, Charles E. Mowbray, Jadel M. Kratz, Luiz C. Dias
Publikováno v:
ACS Omega, Vol 9, Iss 20, Pp 22360-22370 (2024)
Externí odkaz:
https://doaj.org/article/181f8460774544aa8d922443939c65c7
Autor:
Marilia Valli, Thiago H. Döring, Edgard Marx, Leonardo L. G. Ferreira, José L. Medina-Franco, Adriano D. Andricopulo
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 1033 (2024)
The development of new treatments for neglected tropical diseases (NTDs) remains a major challenge in the 21st century. In most cases, the available drugs are obsolete and have limitations in terms of efficacy and safety. The situation becomes even m
Externí odkaz:
https://doaj.org/article/4137cad28837453da4bbf95bd02e1a64
Autor:
Alejandro Gómez-García, Daniel A. Acuña Jiménez, William J. Zamora, Haruna L. Barazorda-Ccahuana, Miguel Á. Chávez-Fumagalli, Marilia Valli, Adriano D. Andricopulo, Vanderlan da S. Bolzani, Dionisio A. Olmedo, Pablo N. Solís, Marvin J. Núñez, Johny R. Rodríguez Pérez, Hoover A. Valencia Sánchez, Héctor F. Cortés Hernández, José L. Medina-Franco
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1388 (2023)
The number of databases of natural products (NPs) has increased substantially. Latin America is extraordinarily rich in biodiversity, enabling the identification of novel NPs, which has encouraged both the development of databases and the implementat
Externí odkaz:
https://doaj.org/article/a79876af93284f3a850bb4773f0b49fc
Autor:
Rogério P. Xavier, Ana C. Mengarda, Marcos P. Silva, Daniel B. Roquini, Maria C. Salvadori, Fernanda S. Teixeira, Pedro L. Pinto, Thiago R. Morais, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Josué de Moraes
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-12 (2020)
Abstract Background Schistosomiasis is a socioeconomically devastating parasitic infection afflicting hundreds of millions of people and animals worldwide. It is the most important helminth infection, and its treatment relies solely on the drug prazi
Externí odkaz:
https://doaj.org/article/2eb280a93e1a48be8e0834eceb1b9ebb
Autor:
Valkiria Machado, Arthur R. Cenci, Kerolain F. Teixeira, Larissa Sens, Tiago Tizziani, Ricardo J. Nunes, Leonardo L. G. Ferreira, Rosendo A. Yunes, Louis P. Sandjo, Adriano D. Andricopulo, Aldo S. de Oliveira
Publikováno v:
RSC Medicinal Chemistry. 13:1644-1656
Alzheimer's disease (AD) is a neurodegenerative disease that is characterized as the main dementia in the elderly. Eighteen pyrazolines were synthesized and evaluated for their inhibitory effects against acetylcholinesterase (AChE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf56128e2c47ab5661faa45e09d9571c
https://doi.org/10.1039/d2md00262k
https://doi.org/10.1039/d2md00262k
Autor:
Simone Michelan-Duarte, Julia M. Souza, Camila H. Ogihara, Lucas dos S. Mello, José Wilmo da Cruz Júnior, Adriano D. Andricopulo, María J. Dávila-Rodríguez, Leonardo L. G. Ferreira, Edward R. Dockal, David L. Palomino-Salcedo, Aldo Sena de Oliveira, Thiago Henrique Döring
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Background: Schiff bases are synthetically accessible compounds that have been used in medicinal chemistry. Methods & results: In this work, 27 Schiff bases derived from diaminomaleonitrile were synthesized in high yields (80–98%). Molecular dockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870eab8950b1b42a4c5c5e2fa97bbb0b
https://doi.org/10.4155/fmc-2021-0194
https://doi.org/10.4155/fmc-2021-0194