Zobrazeno 1 - 10
of 157 538
pro vyhledávání: '"Adriano A"'
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2
Autor:
Kathi Ging, Lukas Frick, Johannes Schlachetzki, Andrea Armani, Yanping Zhu, Pierre-André Gilormini, Ashutosh Dhingra, Desirée Böck, Ana Marques, Matthew Deen, Xi Chen, Tetiana Serdiuk, Chiara Trevisan, Stefano Sellitto, Claudio Pisano, Christopher K. Glass, Peter Heutink, Jiang-An Yin, David J. Vocadlo, Adriano Aguzzi
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract Mutations in GBA1 encoding the lysosomal enzyme β-glucocerebrosidase (GCase) are among the most prevalent genetic susceptibility factors for Parkinson’s disease (PD), with 10–30% of carriers developing the disease. To identify genetic m
Externí odkaz:
https://doaj.org/article/4c0ae1d7d594437b8f6bf9199fd5b7f6
Autor:
Daniella Castro Araújo, Alexandre Afonso de Macedo, Adriano Alonso Veloso, Patricia Nessralla Alpoim, Karina Braga Gomes, Maria das Graças Carvalho, Luci Maria SantAna Dusse
Publikováno v:
BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Objective This study introduces the complete blood count (CBC), a standard prenatal screening test, as a biomarker for diagnosing preeclampsia with severe features (sPE), employing machine learning models. Methods We used a boosting machine
Externí odkaz:
https://doaj.org/article/02382fb441d441c68ce1762150b9338e
Autor:
Julia Sala-Jarque, Vanessa Gil, Pol Andrés-Benito, Inés Martínez-Soria, Pol Picón-Pagès, Félix Hernández, Jesús Ávila, José Luis Lanciego, Mario Nuvolone, Adriano Aguzzi, Rosalina Gavín, Isidro Ferrer, José Antonio del Río
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The cellular prion protein (PrPC) plays many roles in the developing and adult brain. In addition, PrPC binds to several amyloids in oligomeric and prefibrillar forms and may act as a putative receptor of abnormal misfolded protein species.
Externí odkaz:
https://doaj.org/article/2f78e00735454e27858d150cc64c59b9
Autor:
Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niklas Bargenda, Niels J Rupp, Manfredi C Carta, Karl J Frontzek, Veronika Lysenko, Regina R Reimann, Petra Schwarz, Mario Nuvolone, Gunilla T Westermark, K Peter R Nilsson, Magdalini Polymenidou, Alexandre PA Theocharides, Simone Hornemann, Paola Picotti, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2024-2042 (2024)
Abstract Extracellularly released molecular inflammasome assemblies -ASC specks- cross-seed Aβ amyloid in Alzheimer’s disease. Here we show that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease caused b
Externí odkaz:
https://doaj.org/article/361701b3ccf5457e8ccf997a37e06f01
Autor:
Wagner C. A. Carvalho, Rayane A. S. Freitas, Milson S. Barbosa, Ariela V. Paula, Ernandes B. Pereira, Adriano A. Mendes, Elton Franceschi, Cleide M. F. Soares
Publikováno v:
AIMS Bioengineering, Vol 11, Iss 2, Pp 185-211 (2024)
Due to the need to replace lubricants derived from polluting processes and inputs, bioprocesses and raw materials such as vegetable oils have been used for the production of biolubricants. In this study, the synthesis of esters with lubricating poten
Externí odkaz:
https://doaj.org/article/df81cddb7bb94d4286a84eac415c9439
Autor:
Luigi T. DeLuca, Adriano Annovazzi
Publikováno v:
FirePhysChem, Vol 4, Iss 2, Pp 146-165 (2024)
Burning rate plays a crucial role in determining the performance of solid rocket motors (SRMs). In the traditional approach for solid propellant propulsion, technical activities regarding burning rates are developed at three different operational lev
Externí odkaz:
https://doaj.org/article/cf1cdf0a6af246118ff59b8621f0da2c
Autor:
Roberto Dias de Oliveira, Andrea da Silva Santos, Crhistinne Cavalheiro Maymone Gonçalves, Marta Giovanetti, Luiz Carlos Junior Alcantara, Luiz Henrique Ferraz Demarchi, Gislene Garcia de Castro Lichs, Thaissa Mendes Ilis, Suzana Teruya Hiane, Adriano Abbud, Cláudio Tavares Sacchi, Felipe Gomes Naveca, Devanildo de Souza Santos, Edvan Marcelo Morais Marques, Waldno Pereira de Lucena Junior, Julio Croda
Publikováno v:
Travel Medicine and Infectious Disease, Vol 62, Iss , Pp 102782- (2024)
Externí odkaz:
https://doaj.org/article/49159a422b3e41819845a570075cd589
Publikováno v:
Revista de Estudos em Educação e Diversidade, Vol 5, Iss 12 (2024)
Este artigo busca demonstrar que a abordagem didática conhecida como Sala de Sula Invertida (SAI ou Flipped Classroom) tende a ser um instrumento potente para o ensino da matemática sob uma perspectiva crítica. Para tanto empregou-se uma ampla rev
Externí odkaz:
https://doaj.org/article/e171a6e0e3ef4c3f9057b1c091b61316
Autor:
Qianqian Du, Zhaoqiu Liu, Hongmei Wang, Yani Wang, Li Liu, Xuexia Wen, Sangjie Yu, Qingqing Ren, Elisa Gonzalez, Adriano Arguedas, Mark A. Fletcher, Kaijie Pan, Graciela Del Carmen Morales, Jikui Deng, Kaihu Yao
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
ObjectivesTo describe the carriage rate, serotype distribution, and antimicrobial susceptibility patterns of Streptococcus pneumoniae (S. pneumoniae) nasopharyngeal (NP) isolates among healthy children aged 30 days to
Externí odkaz:
https://doaj.org/article/153de2b5b4d44e0e9447d388c926beff
Autor:
Daniella Castro Araujo, Bruno Aragão Rocha, Karina Braga Gomes, Daniel Noce da Silva, Vinicius Moura Ribeiro, Marco Aurelio Kohara, Fernanda Tostes Marana, Renata Andrade Bitar, Adriano Alonso Veloso, Maria Carolina Pintao, Flavia Helena da Silva, Celso Ferraz Viana, Pedro Henrique Araújo de Souza, Ismael Dale Cotrim Guerreiro da Silva
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Optimizing early breast cancer (BC) detection requires effective risk assessment tools. This retrospective study from Brazil showcases the efficacy of machine learning in discerning complex patterns within routine blood tests, presenting a g
Externí odkaz:
https://doaj.org/article/aeaa92db96174e65ab4323bbad1fd6ea