Výsledky vyhledávání - "Adrianne Wallace-Povrik"

Abstract 2798: Folate receptor-targeted cancer chemotherapy with novel 6-substituted thieno[2,3-d]pyrimidine compounds with nitrogen and fluorine containing aromatic side chains as de novo purine biosynthesis inhibitors

Autor: Adrianne Wallace Povrik, Carrie O. Connor, Larry Matherly, Aleem Gangjee, Nian Tong, Jianjun Hou

Publikováno v: Cancer Research. 78:2798-2798

Targeted cancer chemotherapy inhibits the growth of cancer cells by interfering with critical pathways required for tumor progression. Three major transporters are involved in membrane transport of folates into mammalian cells and include the reduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::195d876fb8e30b40824567afaa2b8278
https://doi.org/10.1158/1538-7445.am2018-2798

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Abstract 5123: Targeted thieno[2,3-d]pyrimidines with fluorinated phenyl side chains as antitumor agents

Autor: Larry H. Matherly, Aamod Aamod Dekhneb, Nian Tong, Aleem Gangjee, Adrianne Wallace Povrik, Zhanjun Hou, Carrie O'Connor

Publikováno v: Cancer Research. 77:5123-5123

The reduced folate carrier (RFC) is ubiquitously expressed in tissues and tumors and is the major tissue transporter for folate cofactors. Folate receptor (FR) α and β, as well as the proton-coupled folate transporter (PCFT), exhibit narrower patte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::024ee420bd6c414ebd75104ee4c4b3b5
https://doi.org/10.1158/1538-7445.am2017-5123

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Abstract 1365: Pseudo-cis and pseudo-trans amide conformations lead to potent targeted antifolates that are selectively transported by FR over RFC

Autor: Adrianne Wallace-Povrik, Zhanjun Hou, Aleem Gangjee, Larry H. Matherly, Weiguo Xiang, Carrie O'Connor, Aamod Dehkne, Mike R. Wilson

Publikováno v: Cancer Research. 76:1365-1365

Drugs usually bind to different targets in different conformations. As antitumor agents, antifolates first need to be selectively transported by tumor cells via the reduced folate carrier (RFC), the proton-coupled folate transporter (PCFT) or folate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::029518a0275a12f80de67b72b6124c53
https://doi.org/10.1158/1538-7445.am2016-1365

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Abstract 1359: Design, synthesis and evaluation of fluorinated antifolates for improved selectivity and potency against tumor cells

Autor: Manasa P. Ravindra, Larry H. Matherly, Aleem Gangjee, Lisa P. Hou, Adrianne Wallace Povrik, Mike R. Wilson, Zhanjun Hou, Carrie O'Connor

Publikováno v: Cancer Research. 76:1359-1359

Folates are important single carbon transferring cofactors required for the biosynthesis of purine and pyrimidine nitrogen bases and DNA. Antifolates inhibit synthesis of these nitrogenous bases and function as antineopastic agents. The use of curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32fb4116558e6c87174bed4e901a7f31
https://doi.org/10.1158/1538-7445.am2016-1359

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Abstract 4836: Targeted antifolates with thienoyl regioisomers in the side chain result in improved selectivity and potency against KB human tumor cells

Autor: Larry H. Matherly, Nian Tong, Aleem Gangjee, Zhanjun Hou, Adrianne Wallace Povrik

Publikováno v: Cancer Research. 76:4836-4836

Folates function as cofactors in one-carbon transfer reactions including de novo biosynthesis of nucleotides and play a key in DNA and RNA synthesis, epigenetic processes, cellular proliferation and survival. Cellular folate uptake is mediated by thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f60d3f94f06f45a4dea09d60d29be82a
https://doi.org/10.1158/1538-7445.am2016-4836

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