Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

Autor: Axel Walch, Irina Ingold, Antonella Roveri, Marcus Conrad, Katalin Buday, Michaela Aichler, Fulvio Ursini, Nils Hoffard, Wolfgang Wurst, Elena Yefremova, Adrianne Tasdemir, Sebastian Doll, José Pedro Friedmann Angeli

Publikováno v: The journal of biological chemistry 290(23), 14668-14678 (2015). doi:10.1074/jbc.M115.656363
J. Biol. Chem. 290, 14668-14678 (2015)

The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06560dec7a5747f910bb964c58412bc9
https://doi.org/10.1074/jbc.m115.656363