Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adrianna K. San Roman"'
Autor:
Adrianna K. San Roman, Helen Skaletsky, Alexander K. Godfrey, Neha V. Bokil, Levi Teitz, Isani Singh, Laura V. Blanton, Daniel W. Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Angela E. Lin, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100462- (2024)
Summary: Somatic cells of human males and females have 45 chromosomes in common, including the “active” X chromosome. In males the 46th chromosome is a Y; in females it is an “inactive” X (Xi). Through linear modeling of autosomal gene expres
Externí odkaz:
https://doaj.org/article/f7bcee4c14104a018d0e1ee125035ddd
Autor:
Adrianna K. San Roman, Alexander K. Godfrey, Helen Skaletsky, Daniel W. Bellott, Abigail F. Groff, Hannah L. Harris, Laura V. Blanton, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 3, Iss 2, Pp 100259- (2023)
Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis. Our linear modeling re
Externí odkaz:
https://doaj.org/article/a25725f53e0c4b88aad1b61692c510c9
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 673-681 (2015)
Lgr5-expressing intestinal stem cells (ISCs) renew the adult gut epithelium by producing mature villus cells (VCs); the transcriptional basis for ISC functions remains unclear. RNA sequencing analysis identified transcripts modulated during different
Externí odkaz:
https://doaj.org/article/f3fa9b1b10b34cd18add73b4dfd9832c
Publikováno v:
Stem Cell Reports, Vol 2, Iss 2, Pp 127-134 (2014)
Wnt signaling is a crucial aspect of the intestinal stem cell niche required for crypt cell proliferation and differentiation. Paneth cells or subepithelial myofibroblasts are leading candidate sources of the required Wnt ligands, but this has not be
Externí odkaz:
https://doaj.org/article/4e27c0601e1f4322a39306ff802cdd24
Autor:
Åsa Bonnard, Adrianna K. San Roman, Barbara Flink, Evan Los, Kimberly Earle, Angela E. Lin, Melissa Crenshaw, Siddharth K. Prakash
Publikováno v:
American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 181:22-28
At the Third Turner Resource Network Symposium, a working group presented the results of collaborative discussions about the importance of autopsy in Turner syndrome (TS). Considerable gaps in understanding the causes of death in TS can only be close
Autor:
Xiaofeng Wang, Adrianna K. San Roman, Burak H. Alver, Charles W. M. Roberts, Agoston T. Agoston, Boris G. Wilson, Radhika Mathur, Peter J. Park, Ramesh A. Shivdasani
Publikováno v:
Nature genetics
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are collectively mutated in ∼20% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis
Autor:
David C. Page, Adrianna K. San Roman
Publikováno v:
PMC
Sex chromosome constitution varies in the human population, both between the sexes (46,XX females and 46,XY males), and within the sexes (e.g., 45,X and 46,XX females, and 47,XXY and 46,XY males). Coincident with this genetic variation are numerous p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b337ddecc7b1e63e6b226cfee15954
https://hdl.handle.net/1721.1/125103
https://hdl.handle.net/1721.1/125103
Autor:
Erin A. McNamara, Raul E. Piña-Aguilar, Frances J. Hayes, Marcie A. Steeves, Lynne L. Levitsky, Emma A Snyder, Angela E. Lin, Adrianna K. San Roman, Irene Souter
Publikováno v:
European Journal of Medical Genetics. 64:104140
Despite numerous clinical series, consistent karyotype-phenotype correlations for Turner syndrome have not been established, although a lower level of 45,X is generally thought to be associated with a milder phenotype. This limits personalized counse
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 5, Iss 5, Pp 673-681 (2015)
Stem Cell Reports, Vol 5, Iss 5, Pp 673-681 (2015)
Summary Lgr5-expressing intestinal stem cells (ISCs) renew the adult gut epithelium by producing mature villus cells (VCs); the transcriptional basis for ISC functions remains unclear. RNA sequencing analysis identified transcripts modulated during d
Autor:
Michael P. Verzi, Stephen D. Krasinski, Ramesh A. Shivdasani, Adrianna K. San Roman, Boaz E. Aronson
Publikováno v:
Journal of Biological Chemistry. 290:1850-1860
Distinct groups of transcription factors (TFs) assemble at tissue-specific cis-regulatory sites, implying that different TF combinations may control different genes and cellular functions. Within such combinations, TFs that specify or maintain a line