Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.

Autor: Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S A Pereira, Gilbert Oliveira Silveira, David da Silva Pires, Sergio Verjovski-Almeida, Frank J Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes-Torres, Dina Robaa, Wolfgang Sippl, Raymond J Pierce, M Teresa Borrello, A Ganesan, Julien Lancelot, Silvana Thiengo, Monica Ammon Fernandez, Amanda Roberta Revoredo Vicentino, Marina Moraes Mourão, Fernanda Sales Coelho, Marcelo Rosado Fantappié

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008332 (2020)

Treatment and control of schistosomiasis still rely on only one effective drug, praziquantel (PZQ) and, due to mass treatment, the increasing risk of selecting for schistosome strains that are resistant to PZQ has alerted investigators to the urgent

Externí odkaz: https://doaj.org/article/f432fe7b163b45aa9006ab8d3eb9c2cc

Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.

Autor: Adriana S A Pereira, Murilo S Amaral, Elton J R Vasconcelos, David S Pires, Huma Asif, Lucas F daSilva, David A Morales-Vicente, Vitor C Carneiro, Claudia B Angeli, Giuseppe Palmisano, Marcelo R Fantappie, Raymond J Pierce, João C Setubal, Sergio Verjovski-Almeida

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006873 (2018)

BACKGROUND:The possibility of emergence of praziquantel-resistant Schistosoma parasites and the lack of other effective drugs demand the discovery of new schistosomicidal agents. In this context the study of compounds that target histone-modifying en

Externí odkaz: https://doaj.org/article/3fd93080721c4521b0f7d53c1dfc4fc9

Long non-coding RNA levels can be modulated by 5-azacytidine in Schistosoma mansoni

Autor: Eliana Nakano, Lucas K. Imamura, João V. P. Leite, Adriana S. A. Pereira, Lucas F. Maciel, Giovanna G. O. Olberg, Sergio Verjovski-Almeida, Murilo S. Amaral, Patricia A. Miyasato, Gilbert O. Silveira

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical disease that affects more than 200 million people worldwide. There is only one drug indicated for treatment, praziquantel, which may lead to parasite resistance emerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b0068a9d7e60d5629eec2bc789356f
https://pubmed.ncbi.nlm.nih.gov/33299037

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

Autor: David S. Pires, Monica Ammon Fernandez, Adriana S. A. Pereira, Marcelo Rosado Fantappié, Dante Rotili, A. Ganesan, Eduardo José Lopes Torres, Raymond J. Pierce, Sergio Verjovski-Almeida, Frank J. Dekker, M. Teresa Borrello, Marina de Moraes Mourão, Dina Robaa, Murilo S. Amaral, Isabel Caetano de Abreu da Silva, Amanda Roberta Revoredo Vicentino, Gilbert de Oliveira Silveira, Julien Lancelot, Silvana C. Thiengo, Fernanda Sales Coelho, Antonello Mai, Wolfgang Sippl, Vitor Coutinho Carneiro

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (7), pp.e0008332. ⟨10.1371/journal.pntd.0008332⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008332 (2020)
PLoS Neglected Tropical Diseases, 14(7):0008332, 1-29. PUBLIC LIBRARY SCIENCE
PLoS Neglected Tropical Diseases, 2020, 14 (7), pp.e0008332. ⟨10.1371/journal.pntd.0008332⟩

Treatment and control of schistosomiasis still rely on only one effective drug, praziquantel (PZQ) and, due to mass treatment, the increasing risk of selecting for schistosome strains that are resistant to PZQ has alerted investigators to the urgent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dc247d0e79ad2a06cac66b3ba24077
https://pubmed.ncbi.nlm.nih.gov/32609727

The Schistosoma mansoni genome encodes thousands of long non-coding RNAs predicted to be functional at different parasite life-cycle stages

Autor: Murilo S. Amaral, Adriana S. A. Pereira, Sergio Verjovski-Almeida, Elton J R Vasconcelos, Lucas Ferreira daSilva, Guilherme M. Lavezzo, David S. Pires

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Next Generation Sequencing (NGS) strategies, like RNA-Seq, have revealed the transcription of a wide variety of long non-coding RNAs (lncRNAs) in the genomes of several organisms. In the present work we assessed the lncRNAs complement of Schistosoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72416a830644388096f7346f13dc1b2b
http://europepmc.org/articles/PMC5585378