Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Adriana Osickova"'
Autor:
Anna Lepesheva, Adriana Osickova, Jana Holubova, David Jurnecka, Sarka Knoblochova, Carlos Espinosa-Vinals, Ladislav Bumba, Karolina Skopova, Radovan Fiser, Radim Osicka, Peter Sebo, Jiri Masin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the acylated segment of the RTX adenylate cyclas
Externí odkaz:
https://doaj.org/article/6f873568b2e4490a9da5948d8fb80b36
Publikováno v:
Microorganisms, Vol 10, Iss 3, p 518 (2022)
The Gram-negative bacterium Kingella kingae is part of the commensal oropharyngeal flora of young children. As detection methods have improved, K. kingae has been increasingly recognized as an emerging invasive pathogen that frequently causes skeleta
Externí odkaz:
https://doaj.org/article/a4d26f7dd19d4b839a9d67630e4cba84
Autor:
Adriana Osickova, Nataliya Balashova, Jiri Masin, Miroslav Sulc, Jana Roderova, Tomas Wald, Angela C. Brown, Evan Koufos, En Hyung Chang, Alexander Giannakakis, Edward T. Lally, Radim Osicka
Publikováno v:
Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-15 (2018)
Abstract Kingella kingae is a member of the commensal oropharyngeal flora of young children. Improvements in detection methods have led to the recognition of K. kingae as an emerging pathogen that frequently causes osteoarticular infections in childr
Externí odkaz:
https://doaj.org/article/0ad24cd2bb474f8e83870cb95223ed73
Publikováno v:
Toxins, Vol 11, Iss 6, p 336 (2019)
Cytolytic leukotoxins of the repeat in toxin (RTX) family are large proteins excreted by gram-negative bacterial pathogens through the type 1 secretion system (T1SS). Due to low yields and poor stability in cultures of the original pathogens, it is u
Externí odkaz:
https://doaj.org/article/1dc05b4503764fa582bcba2113948f1d
Publikováno v:
eLife, Vol 4 (2015)
Integrins are heterodimeric cell surface adhesion and signaling receptors that are essential for metazoan existence. Some integrins contain an I-domain that is a major ligand binding site. The ligands preferentially engage the active forms of the int
Externí odkaz:
https://doaj.org/article/880acfd41de04a69a30b7144cbb12145
Publikováno v:
Toxins, Vol 10, Iss 6, p 245 (2018)
The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) plays a crucial role in virulence and airway colonization capacity of the whooping cough agent Bordetella pertussis. The toxin penetrates target cell membranes and exhibits three distinct b
Externí odkaz:
https://doaj.org/article/fd1fbc95a09946588edf506840724f29
Autor:
Jakub Novak, Ondrej Cerny, Adriana Osickova, Irena Linhartova, Jiri Masin, Ladislav Bumba, Peter Sebo, Radim Osicka
Publikováno v:
Toxins, Vol 9, Iss 10, p 300 (2017)
Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin–hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host. CyaA subverts host phagocytic cells by an orchestrated acti
Externí odkaz:
https://doaj.org/article/c6ee91ce9982438d94d1b3ecb891ef0a
Autor:
Maryam Golshani, Waheed Ur Rahman, Adriana Osickova, Jana Holubova, Jinery Lora, Nataliya Balashova, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12598
The pertussis agent Bordetella pertussis produces a number of virulence factors, of which the filamentous hemagglutinin (FhaB) plays a role in B. pertussis adhesion to epithelial and phagocytic cells. Moreover, FhaB was recently found to play a cruci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc53f3b39f807d6f69b6901d2103885
Autor:
Maryam, Golshani, Waheed Ur, Rahman, Adriana, Osickova, Jana, Holubova, Jinery, Lora, Nataliya, Balashova, Peter, Sebo, Radim, Osicka
Publikováno v:
International journal of molecular sciences. 23(20)
The pertussis agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e85f74649d74bcc5689e79132067c99
https://pubmed.ncbi.nlm.nih.gov/36293453
https://pubmed.ncbi.nlm.nih.gov/36293453
Autor:
Nela Klimova, Humaira Khaliq, Peter Sebo, David Jurnecka, Adriana Osickova, Jiri Masin, Radim Osicka
Publikováno v:
J Biol Chem
The Bordetella adenylate cyclase toxin-hemolysin (CyaA) and the α-hemolysin (HlyA) of Escherichia coli belong to the family of cytolytic pore-forming Repeats in ToXin (RTX) cytotoxins. HlyA preferentially binds the α(L)β(2) integrin LFA-1 (CD11a/C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530c7aa2f5b82f4b74cc9c16010fb520
https://doi.org/10.1074/jbc.ra120.013630
https://doi.org/10.1074/jbc.ra120.013630