Výsledky vyhledávání - "Adriana M. Godin"

Calix[n]arene-based immunogens: A new non-proteic strategy for anti-cocaine vaccine

Autor: Raissa Lima Gonçalves Pereira, Angélica Faleiros da Silva Maia, Frederico Duarte Garcia, Felipe T. Martins, Gisele Assis Castro Goulart, Adriana M. Godin, Paulo S. A. Augusto, Leonardo da Silva Neto, Rosemeire B. Alves, Ângelo de Fátima, Valbert Nascimento Cardoso, Sordaini M. Caligiorne, Simone Odília Antunes Fernandes, Maila de Castro Lourenço das Neves

Publikováno v: Journal of Advanced Research. 38:285-298

Introduction Cocaine use disorder is a significant public health issue without a current specific approved treatment. Among different approaches to this disorder, it is possible to highlight a promising immunologic strategy in which an immunogenic ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3935c76faf84efbafa77f29e561ff4b5
https://doi.org/10.1016/j.jare.2021.09.003

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The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain

Autor: Renes R. Machado, Márcio M. Coelho, Ivo S.F. Melo, Marcela M.G.B. Dutra, Adriana M. Godin, Tamires C. Matsui, Wagner G. Canhestro, Ângelo de Fátima, Ana Mercy S. Brito, Ricardo José Alves, Giovanna M.E. Coura, Débora P. Araújo, Carla R.A. Batista

Publikováno v: Pharmacological Reports. 71:1177-1183

Phthalimide analogues devoid of the glutarimide moiety exhibit multiple biological activities, thus making them candidates for the treatment of patients with different diseases, including those with inflammatory and painful disorders. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae93c2a1cd16bee68f042aa0837bd3e
https://doi.org/10.1016/j.pharep.2019.08.001

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Chenopodin as an anti-inflammatory compound

Autor: Renes R. Machado, Flávia Cristina Policarpo Tonelli, Helon Guimarães Cordeiro, Márcio M. Coelho, Ivo S.F. Melo, José Antônio da Silva, Adriana M. Godin, Tamires C. Matsui, Dávia Guimarães Pompeu, Paulo Afonso Granjeiro, Felipe F. Rodrigues

Publikováno v: Natural product research. 36(17)

Chenopodin is an 11S-type globulin purified from Chenopodium quinoa seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ae338ae01eba43380aa0802e349e60
https://pubmed.ncbi.nlm.nih.gov/34544288

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Delay of neuropathic pain sensitization after application of dexamethasone-loaded implant in sciatic nerve-injured rats

Autor: Armando Silva-Cunha, Márcio M. Coelho, Raquel Rezende Menezes, Márcio Flávio Dutra Moraes, Bruna Lopes da Costa, Lirlândia P. Sousa, Juliana P. Vago, Sílvia Ligório Fialho, Renes R. Machado, Roberta Ribas Pena, Leandro F.S. Bastos, Adriana M. Godin, Thais Rolla de Caux

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 55 (2019)
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18112
Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18112
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP

Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f85765341b0f68a8c7c2d0f800a983a
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100591&tlng=en

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Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1

Autor: Marcela I. Morais, Raquel R. Menezes, Felipe F. Rodrigues, Márcio M. Coelho, Sarah O.A.M. Costa, Ivo S.F. Melo, Marcela G.M.B. Dutra, Ana Mercy S. Brito, Renes R. Machado, Franciele A. Goulart, Paulo S. A. Augusto, Adriana M. Godin

Publikováno v: European Journal of Pharmacology. 818:17-25

Leflunomide, an immunosuppressive drug approved for the treatment of patients with rheumatoid arthritis, exhibits many mechanisms which may affect the nociceptive processing. Therefore, the present study aimed to evaluate the effect induced by leflun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a5b1425febef8fabdea73942671329
https://doi.org/10.1016/j.ejphar.2017.10.026

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2-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation

Autor: Ana Mercy S. Brito, Giovanna M.E. Coura, Raquel R. Menezes, Mauro M. Teixeira, Adriana M. Godin, Ivo S.F. Melo, Débora P. Araújo, Ângelo de Fátima, Márcio M. Coelho, Flávio A. Amaral, Renes R. Machado, Leandro F.S. Bastos

Publikováno v: Pharmacological Reports. 69:691-695

Phthalimide analogs have been shown to exhibit anti-inflammatory, analgesic and immunomodulatory activities in different preclinical assays. This study aimed to investigate the potential role of 2-phthalimidethanol (PTD-OH) and 2-phthalimidethyl nitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51af0ca37e14f726b50b8c93aebd13ba
https://doi.org/10.1016/j.pharep.2017.01.033

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Nicorandil inhibits neutrophil recruitment in carrageenan-induced experimental pleurisy in mice

Autor: André Klein, Isabela Costa César, Giovanna M.E. Coura, Tamires C. Matsui, Danielle G. Souza, Lucas S. Ribeiro, Renes R. Machado, Adriana M. Godin, Paulo S. A. Augusto, Ivo S.F. Melo, Débora P. Araújo, Ângelo de Fátima, Márcio M. Coelho, Carla R.A. Batista

Publikováno v: European Journal of Pharmacology. 769:306-312

Nicorandil is a drug characterized by the coupling of a nitric oxide (NO) donor to nicotinamide. We have previously demonstrated that nicotinamide exhibits activity in different models of pain and inflammation. Now, we investigated the effects induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b610bdaedf2bf8051d6ee0ef63a172b3
https://doi.org/10.1016/j.ejphar.2015.11.034

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Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers

Autor: Julliana Ribeiro Alves Santos, Adriana M. Godin, Gerson Antônio Pianetti, Francinely C. Oliveira, Márcio M. Coelho, Débora P. Araújo, Renes R. Machado, Mariana O. Almeida, Raquel R. Menezes, Ângelo de Fátima, Marcela M.G.B. Dutra, Isabela Costa César, Daniel Assis Santos

Publikováno v: Bioorganic & Medicinal Chemistry. 22:2783-2790

Nicorandil (N-(2-hydroxyethyl)nicotinamide nitrate) is an antianginal drug, which activates guanylyl cyclase and opens the ATP-dependent K(+) channels, actions that have been suggested to mediate its vasodilator activity. We synthesized nicorandil an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1038bbd8b0a091a53b049163acdf6ce5
https://doi.org/10.1016/j.bmc.2014.03.011

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