Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Adriana Irimia"'
Autor:
Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, Michael B. Zwick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis s
Externí odkaz:
https://doaj.org/article/706277bc9dfa4fb4814343163603b088
Autor:
Kimmo Rantalainen, Zachary T. Berndsen, Aleksandar Antanasijevic, Torben Schiffner, Xi Zhang, Wen-Hsin Lee, Jonathan L. Torres, Lei Zhang, Adriana Irimia, Jeffrey Copps, Kenneth H. Zhou, Young D. Kwon, William H. Law, Chaim A. Schramm, Raffaello Verardi, Shelly J. Krebs, Peter D. Kwong, Nicole A. Doria-Rose, Ian A. Wilson, Michael B. Zwick, John R. Yates, III, William R. Schief, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Structural and functional studies of HIV envelope glycoprotein (Env) as a transmembrane protein have long been complicated by challenges associated with inherent flexibility of the molecule and the membrane-embedded hydrophobic regions. Here
Externí odkaz:
https://doaj.org/article/d9f16fbf109a4f2f9110c0d89c79dd68
Autor:
Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al. show that a cleavage-independent Env construct recapitulates the architect
Externí odkaz:
https://doaj.org/article/5ebe9459afc54000bd784b1509c2346e
Autor:
Adriana Irimia, Andreia M Serra, Anita Sarkar, Ronald Jacak, Oleksandr Kalyuzhniy, Devin Sok, Karen L Saye-Francisco, Torben Schiffner, Ryan Tingle, Michael Kubitz, Yumiko Adachi, Robyn L Stanfield, Marc C Deller, Dennis R Burton, William R Schief, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006212 (2017)
Among broadly neutralizing antibodies to HIV, 10E8 exhibits greater neutralizing breadth than most. Consequently, this antibody is the focus of prophylactic/therapeutic development. The 10E8 epitope has been identified as the conserved membrane proxi
Externí odkaz:
https://doaj.org/article/f681c9af5ada49bfa2774b8fa38434ae
Autor:
Pascal Poignard, Daniel P. Leaman, Jiang Zhu, Kimmo Rantalainen, Armando Stano, Michael B. Zwick, Andrew B. Ward, Adriana Irimia, Daniel I. Sands, Ian A. Wilson, Thomas Vollbrecht, Dennis R. Burton, Arthur S. Kim, Lei Zhang, Elise Landais, Ben Murrell, Lingling He
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER antibodies usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f122d9dd5cd45602f0b6d142d1fc270
http://link.springer.com/article/10.1038/s41467-019-12973-1
http://link.springer.com/article/10.1038/s41467-019-12973-1
Autor:
Jae Hyun Bae, Erin D. Lew, Jun Feng, Marcos Gonzalez-Lopez, Joanne Oh, Patrick Fagan, Matt Salie, Nick Isley, Richard Lam, Adriana Irimia, Robin Nevarez, Bingzhen Lin, Taylor Congdon, Jingchuan Zhang, Dawei Xuan, Ping Chen, Jean-Michel Vernier, Robert Shoemaker
Publikováno v:
Cancer Research. 82:2675-2675
The RAS family of GTPases, which include KRAS, NRAS, and HRAS, are key regulators of cellular signaling, acting as molecular switches downstream of receptor tyrosine kinases (RTKs) and as key regulators of the RAS/MAPK pathway. RAS cycles between ina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d4b3a75528e31caf66d2f6c649312d
https://doi.org/10.1158/1538-7445.am2022-2675
https://doi.org/10.1158/1538-7445.am2022-2675
Autor:
Kenneth H. Zhou, Nicole A. Doria-Rose, Wen-Hsin Lee, Andrew B. Ward, Lei Zhang, Peter D. Kwong, Chaim A. Schramm, Xi Zhang, Young Do Kwon, John R. Yates, Jonathan L. Torres, Raffaello Verardi, Michael B. Zwick, Kimmo Rantalainen, Shelly J. Krebs, Zachary T. Berndsen, William H. Law, Ian A. Wilson, Adriana Irimia, Torben Schiffner, Aleksandar Antanasijevic, William R. Schief, Jeffrey Copps
Publikováno v:
Cell Reports
Cell Reports, Vol 31, Iss 4, Pp-(2020)
Cell Reports, Vol 31, Iss 4, Pp-(2020)
Summary Structural and functional studies of HIV envelope glycoprotein (Env) as a transmembrane protein have long been complicated by challenges associated with inherent flexibility of the molecule and the membrane-embedded hydrophobic regions. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec6321e965e9de33ca740911d1bf9c5
https://pubmed.ncbi.nlm.nih.gov/32348769
https://pubmed.ncbi.nlm.nih.gov/32348769
Publikováno v:
Immunity. 44(1):21-31
Numerous studies of the anti-HIV-1 envelope glycoprotein 41 (gp41) broadly neutralizing antibody 4E10 suggest that 4E10 also interacts with membrane lipids, but the antibody regions contacting lipids and its orientation with respect to the viral memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04118d6f08e5df84b4304c167a241cd
Autor:
Richard T. Wyatt, Anna-Janina Behrens, N. de Val, Jesper Pallesen, Sonu Kumar, Andrew B. Ward, Anita Sarkar, Shridhar Bale, Robyn L. Stanfield, Shailendra Kumar Sharma, Max Crispin, Adriana Irimia, Ian A. Wilson, Devan Diwanji
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Furin cleavage of the HIV envelope glycoprotein is an essential step for cell entry that enables formation of well-folded, native-like glycosylated trimers, releases constraints on the fusion peptide, and limits enzymatic processing of the N-glycan s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685e95faa8d52da1958f3daf7f0c9162
https://eprints.soton.ac.uk/421294/
https://eprints.soton.ac.uk/421294/
Autor:
James C. Paulson, Zinaida Polonskaya, Lisa Kain, Shane Crotty, Stephen P. Schoenberger, Sanjay Mehta, Shenglou Deng, Anita Sarkar, Seth R. Taylor, Marta Comellas-Aragones, Jennifer M. Dan, Katarzyna Kaczanowska, Kevin M. Self, Craig S. McKay, Matthew T. Brigger, Valle Palomo, M. G. Finn, Luc Teyton, Adriana Irimia, Ryan McBride, Ian A. Wilson, Paul B. Savage, Marie Holt
Publikováno v:
The Journal of clinical investigation. 127(4)
Vaccines targeting glycan structures at the surface of pathogenic microbes must overcome the inherent T cell-independent nature of immune responses against glycans. Carbohydrate conjugate vaccines achieve this by coupling bacterial polysaccharides to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81d07e6ea088779f25872f097b1c824
https://pubmed.ncbi.nlm.nih.gov/28287405
https://pubmed.ncbi.nlm.nih.gov/28287405