Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Adriana Ingrid Velter"'
Autor:
José Manuel Bartolomé-Nebreda, Adriana Ingrid Velter, Peter Jacobus Johannes Antonius Buijnsters, Andrés A. Trabanco
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:1117-1154
Introduction: O-GlcNAcylation is a highly abundant post-translational modification of multiple proteins, including the microtubule-binding protein tau, governed by just two enzymes’ concerted actio...
Autor:
Garrett Berlond Minne, Michel Surkyn, Harrie J.M. Gijsen, Francois Paul Bischoff, Nigel Austin, Marc Mercken, Didier Berthelot, Chiara Zavattaro, Ishtiyaque Ahmad, Gregor James Macdonald, Adriana Ingrid Velter, Michel Anna Jozef De Cleyn, Deborah Dhuyvetter, Sven Franciscus Anna Van Brandt, Serge Maria Aloysius Pieters, Yves Emiel Maria Van Roosbroeck, Swapan Kumar Samanta, Herman Borghys
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(14)
The discovery, design and synthesis of a new series of GSMs is described. The classical imidazole heterocycle has been replaced by a cyano group attached to an indole nucleus. The exploration of this series has led to compound 26-S which combined hig
Autor:
Brian Lord, Jason C. Rech, Brian Scott, Kirsten L. Morton, Nicholas I. Carruthers, Victor Contreras, Natalie A. Hawryluk, Qi Wang, Xiaohui Jiang, Francois Paul Bischoff, Michael A. Letavic, Alan D. Wickenden, Pascal Bonaventure, Hong Ao, Serge Maria Aloysius Pieters, Zachary S. Sales, Anindya Bhattacharya, Adriana Ingrid Velter
Publikováno v:
ACS Medicinal Chemistry Letters. 4:419-422
The synthesis and preclinical characterization of two novel, brain penetrating P2X7 compounds will be described. Both compounds are shown to be high potency P2X7 antagonists in human, rat, and mouse cell lines and both were shown to have high brain c
Autor:
Harrie J.M. Gijsen, Francois Paul Bischoff, Serge Maria Aloysius Pieters, Yves Emiel Maria Van Roosbroeck, Didier Berthelot, Chantal Masungi, Andrés A. Trabanco, Garrett Berlond Minne, Gary Tresadern, Adriana Ingrid Velter, Frederik J. R. Rombouts, Michel Anna Jozef De Cleyn, Libuse Jaroskova, Michel Surkyn, Tongfei Wu, Sven Franciscus Anna Van Brandt, Daniel Oehlrich, Gregor James Macdonald, Herman Borghys, Marc Mercken
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(24)
The design and synthesis of a novel series of potent gamma secretase modulators is described. Exploration of various spacer groups between the triazole ring and the aromatic appendix in 2 has led to anilinotriazole 28, which combined high in vitro an
Autor:
Adriana Ingrid Velter, Michel Anna Jozef De Cleyn, Frederik J. R. Rombouts, Sven Franciscus Anna Van Brandt, Didier Berthelot, Andrés A. Trabanco, Marc Mercken, Francois Paul Bischoff, Harrie J.M. Gijsen, Michel Surkyn, Tongfei Wu, Daniel Oehlrich, Libuse Jaroskova, Gregor James Macdonald, Gary Tresadern
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(17)
The evolution of amide 3 into conformationally restricted bicyclic triazolo-piperidine 14-S as a γ-secretase modulator is described. This is a potential disease modifying anti-Alzheimer’s drug which demonstrated high in vitro and in vivo potency a