Comparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy

Autor: Mei Liu, Adriana Hernandez-Morales, James Clark, Tram Le, Biswajit Biswas, Kimberly A. Bishop-Lilly, Matthew Henry, Javier Quinones, Logan J. Voegtly, Regina Z. Cer, Theron Hamilton, Robert T. Schooley, Scott Salka, Ry Young, Jason J. Gill

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

A patient with a multidrug-resistant bacterial infection was successfully treated in 2016 using phage therapy. Here, the authors sequence the genomes of the therapeutic phages and three bacterial strains isolated before and during treatment, and show

Externí odkaz: https://doaj.org/article/0bae7b978fe14271a0dd264dacfcecf8

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

Autor: Adriana Hernandez-Morales, Lu Jiang, Trevor D. Lawley, Yi Duan, Peter Stärkel, Huikuan Chu, David T. Pride, Imran R Rahman, Philippe Mathurin, Bei Gao, Katharina Brandl, Francisco Bosques-Padilla, Yan Shao, Michael R. Lucey, Felix Hutmacher, Alexandre Louvet, Manolito Torralba, Ramon Bataller, Debbie L. Shawcross, Robert S. Brown, Suhan Lee, Derrick E. Fouts, Wilfred A. van der Donk, Jinyuan Liu, Weizhong Sun, Sonja Lang, Melissa Ly, Samuel B. Ho, Roman Kiesel, Kevin Nguyen, Juan G. Abraldes, Richard C. White, Guadalupe Garcia-Tsao, Yukiko Miyamoto, Xin M. Tu, Thomas H. Clarke, Lauren Lessor, José Altamirano, Elizabeth C. Verna, Ry Young, Juan Caballería, Meritxell Ventura-Cots, Victor Vargas, Cristina Llorente, Bernd Schnabl, Lars Eckmann

Publikováno v: Duan, Y, Llorente, C, Lang, S, Brandl, K, Chu, H, Jiang, L, White, R C, Clarke, T H, Nguyen, K, Torralba, M, Shao, Y, Liu, J, Hernandez-Morales, A, Lessor, L, Rahman, I R, Miyamoto, Y, Ly, M, Gao, B, Sun, W, Kiesel, R, Hutmacher, F, Lee, S, Ventura-Cots, M, Bosques-Padilla, F, Verna, E C, Abraldes, J G, Brown, R S, Vargas, V, Altamirano, J, Caballería, J, Shawcross, D L, Ho, S B, Louvet, A, Lucey, M R, Mathurin, P, Garcia-Tsao, G, Bataller, R, Tu, X M, Eckmann, L, van der Donk, W A, Young, R, Lawley, T D, Stärkel, P, Pride, D, Fouts, D E & Schnabl, B 2019, ' Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease ', Nature, vol. 575, no. 7783, pp. 505-511 . https://doi.org/10.1038/s41586-019-1742-x
Nature, Vol. 575, no. 7783, p. 505-511 (2019)
Nature, vol 575, iss 7783

Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden of disease and mortality1–3. Alcoholic hepatitis is a severe and life-threatening form of alcohol-associated liver disease. The gut microbiota promotes etha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f662836a150f4ea4e4e6c2cfd9061bf
https://kclpure.kcl.ac.uk/en/publications/e22cc724-059c-4840-baec-69a76ff63c0d

Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection

Autor: Davey M. Smith, Alfred J. Mateczun, Jeremy J. Barr, Biswajit Biswas, Forest Rohwer, Andrew C. Picel, Lauren Lessor, Steffanie A. Strathdee, Sharon L. Reed, Melanie McCauley, Monika Kumaraswamy, Matthew Henry, Katherine E. Cilwa, Sean Benler, Constance A. Benson, Scott Salka, Kimberly A. Bishop-Lilly, Brian M. Leroux, Jason J. Gill, Javier Quinones, Theron Hamilton, Randy Taplitz, Leo Lin, Robert T. Schooley, Luis A. Estrella, Kim M. Kerr, Robert K. Pope, Anca M. Segall, Victor Nizet, James Regeimbal, Ry Young, Adriana Hernandez-Morales, David M. Wolfe, Jacob C. Lancaster

Publikováno v: Antimicrobial Agents and Chemotherapy. 61

Widespread antibiotic use in clinical medicine and the livestock industry has contributed to the global spread of multidrug-resistant (MDR) bacterial pathogens, includingAcinetobacter baumannii. We report on a method used to produce a personalized ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd3b7b946750770f0537ed4c4b522996
https://doi.org/10.1128/aac.00954-17