Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Adriana Haimovitz-Friedman"'
Autor:
Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao, Guoqiang Hua, Ryan Glass, Phillip B. Paty, Zvi Fuks, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract Previous studies show increased sensitivity of older mice (28–29 months) compared with young adult mice (3 months, possessing a mature immune system) to radiation-induced GI lethality. Age-dependent lethality was associated with higher lev
Externí odkaz:
https://doaj.org/article/0af0995b6bde418190a8d6665f7d9f00
Autor:
Matthias Hose, Anne Günther, Eyad Naser, Fabian Schumacher, Tina Schönberger, Julia Falkenstein, Athanasios Papadamakis, Burkhard Kleuser, Katrin Anne Becker, Erich Gulbins, Adriana Haimovitz-Friedman, Jan Buer, Astrid M Westendorf, Wiebke Hansen
Publikováno v:
eLife, Vol 11 (2022)
Acid sphingomyelinase (Asm) and acid ceramidase (Ac) are parts of the sphingolipid metabolism. Asm hydrolyzes sphingomyelin to ceramide, which is further metabolized to sphingosine by Ac. Ceramide generates ceramide-enriched platforms that are involv
Externí odkaz:
https://doaj.org/article/e8451a73e0d644448fa86305cbe73999
Autor:
Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao, Guoqiang Hua, Ryan Glass, Phillip B. Paty, Zvi Fuks, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/abc9c00ff9e24876a08e7df9fc13cef9
Autor:
Carla Hajj, James Russell, Charles P Hart, Karyn A Goodman, Maeve A Lowery, Adriana Haimovitz-Friedman, Joseph O. Deasy, John L. Humm
Publikováno v:
Translational Oncology, Vol 10, Iss 5, Pp 760-765 (2017)
This study was designed to investigate the effect of single-dose radiation therapy (RT) in combination with evofosfamide (TH-302), a hypoxia-activated prodrug, in a pre-clinical model of pancreatic cancer. AsPC1 tumors were implanted orthotopically i
Externí odkaz:
https://doaj.org/article/cf346b6edb324199981a3b949a7dfb40
Autor:
Aviram Mizrachi, Yosi Shamay, Janki Shah, Samuel Brook, Joanne Soong, Vinagolu K. Rajasekhar, John L. Humm, John H. Healey, Simon N. Powell, José Baselga, Daniel A. Heller, Adriana Haimovitz-Friedman, Maurizio Scaltriti
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Head and neck squamous cell carcinomas (HNSCC) often harbourPIK3CAmutations but PI3Kα inhibitors can cause some side effects. Here, the authors develop P-selectin targeted nanoparticles to enhance tumour-specific delivery of a PI3Kα inhibitor to HN
Externí odkaz:
https://doaj.org/article/85df8a21d4544f45aef7b25946bd4c53
Autor:
Xinzhu Deng, David Michaelson, Jason Tchieu, Jin Cheng, Diana Rothenstein, Regina Feldman, Sang-gyu Lee, John Fuller, Adriana Haimovitz-Friedman, Lorenz Studer, Simon Powell, Zvi Fuks, E Jane Albert Hubbard, Richard Kolesnick
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0141673 (2016)
Externí odkaz:
https://doaj.org/article/97a50e8d002e4651ab01f6568f45bbd3
Autor:
Xinzhu Deng, David Michaelson, Jason Tchieu, Jin Cheng, Diana Rothenstein, Regina Feldman, Sang-gyu Lee, John Fuller, Adriana Haimovitz-Friedman, Lorenz Studer, Simon Powell, Zvi Fuks, E Jane Albert Hubbard, Richard Kolesnick
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127862 (2015)
Mammalian NOTCH1-4 receptors are all associated with human malignancy, although exact roles remain enigmatic. Here we employ glp-1(ar202), a temperature-sensitive gain-of-function C. elegans NOTCH mutant, to delineate NOTCH-driven tumor responses to
Externí odkaz:
https://doaj.org/article/382b1d3647984131982f913d81a6604e
Autor:
Hyunmi Lee, Jimmy A Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0146210 (2015)
Externí odkaz:
https://doaj.org/article/dda7ebbc7ac843c88750940983b5f994
Autor:
Branka Stancevic, Nira Varda-Bloom, Jin Cheng, John D Fuller, Jimmy A Rotolo, Mónica García-Barros, Regina Feldman, Shyam Rao, Ralph R Weichselbaum, Dror Harats, Adriana Haimovitz-Friedman, Zvi Fuks, Michel Sadelain, Richard Kolesnick
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69025 (2013)
These studies define a new mechanism-based approach to radiosensitize tumor cure by single dose radiotherapy (SDRT). Published evidence indicates that SDRT induces acute microvascular endothelial apoptosis initiated via acid sphingomyelinase (ASMase)
Externí odkaz:
https://doaj.org/article/385d5a0a20444620b152eb931564bc92
Autor:
Hyunmi Lee, Jimmy A Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e19783 (2011)
BACKGROUND:Evidence indicates that Bax functions as a "lipidic" pore to regulate mitochondrial outer membrane permeabilization (MOMP), the apoptosis commitment step, through unknown membrane elements. Here we show mitochondrial ceramide elevation fac
Externí odkaz:
https://doaj.org/article/4cc946576a3b43da8e0f310b42c9ba73