Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Adriana Covarrubias"'
Autor:
Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113484- (2023)
Summary: The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent
Externí odkaz:
https://doaj.org/article/c6187d86919640fc8c826a912248ef14
Autor:
Gonzalo Mayorga-Weber, Felipe Beltrán, Leandro Torres, Paulina Troncoso-Escudero, Juan Villalobos-González, Marcelo Lara, Adriana Covarrubias-Pinto, Sharin Valdivia, Isidora Vicencio, Eduardo Papic, Carolina Paredes, Alejandro Rojas, Luis Lamberti, Felipe Court, Abraham Rosas-Arellano, Federico Bátiz, Patricio Rojas, Maite Castro
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S447-S448 (2023)
Externí odkaz:
https://doaj.org/article/4d6b485ef43f439bafc164ae2b3f79c4
Autor:
Ramachandra M. Bhaskara, Paolo Grumati, Javier Garcia-Pardo, Sissy Kalayil, Adriana Covarrubias-Pinto, Wenbo Chen, Mikhail Kudryashev, Ivan Dikic, Gerhard Hummer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and shape of the endoplasmic reticulum. Here authors use molecular modeling and molecular dynamics simulations to assemble a structural model for the reticulon-homology domain o
Externí odkaz:
https://doaj.org/article/55c989931d3643a28f0d1a7f12a1012b
Autor:
Francisca Acuña-Hinrichsen, Adriana Covarrubias-Pinto, Yuta Ishizuka, María Francisca Stolzenbach, Carolina Martin, Paula Salazar, Maite A. Castro, Clive R. Bramham, Carola Otth
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. Under stressful conditions,
Externí odkaz:
https://doaj.org/article/b6e5184e8f7f41ecba33042f5b1afa3f
Autor:
Christina Karantanou, Valentina R. Minciacchi, Rahul Kumar, Costanza Zanetti, Jimena Bravo, Raquel S. Pereira, Georg Tascher, Tobias Tertel, Adriana Covarrubias-Pinto, Katrin Bankov, Lisa-Marie Pfeffermann, Halvard Bonig, Paola Divieti-Pajevic, David G. McEwan, Bernd Giebel, Christian Münch, Ivan Dikic, Daniela S. Krause
Publikováno v:
Blood Advances. 7:1190-1203
Leukemia cells reciprocally interact with their surrounding bone marrow microenvironment (BMM), rendering it hospitable to leukemia cell survival, for instance through the release of small extracellular vesicles (sEVs). In contrast, we show here that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bee0afce27d36b9bd90af1fa87b00cf
https://doi.org/10.1182/bloodadvances.2022007528
https://doi.org/10.1182/bloodadvances.2022007528
Autor:
Johana Spies, Adriana Covarrubias-Pinto, Constanza Carcamo, Yennyfer Arancibia, Fernanda Salazar, Carolina Paredes-Martinez, Carola Otth, Maite Castro, Angara Zambrano
Publikováno v:
Neurochemical Research. 48:2093-2103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c97c01f98bad59545869855a1fafc8
https://doi.org/10.1007/s11064-023-03889-w
https://doi.org/10.1007/s11064-023-03889-w
Autor:
Alexis González, Adriana Covarrubias-Pinto, Ramachandra M. Bhaskara, Marius Glogger, Santosh K. Kuncha, Audrey Xavier, Eric Seemann, Mohit Misra, Marina E. Hoffmann, Bastian Bräuning, Ashwin Balakrishnan, Britta Qualmann, Volker Dötsch, Brenda A. Schulman, Michael M. Kessels, Christian A. Hübner, Mike Heilemann, Gerhard Hummer, Ivan Dikić
Publikováno v:
Nature
The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy1. ER-phagy receptors have a central role in this process2, but the regulatory mechanism remains largely unknown. Here we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98e7e0b5a165c785e9575df9593b097
https://doi.org/10.1038/s41586-023-06089-2
https://doi.org/10.1038/s41586-023-06089-2
Autor:
Hector Foronda, Yangxue Fu, Adriana Covarrubias-Pinto, Hartmut T. Bocker, Alexis González, Eric Seemann, Patricia Franzka, Andrea Bock, Ramachandra M. Bhaskara, Lutz Liebmann, Marina E. Hoffmann, Istvan Katona, Nicole Koch, Joachim Weis, Ingo Kurth, Joseph G. Gleeson, Fulvio Reggiori, Gerhard Hummer, Michael M. Kessels, Britta Qualmann, Muriel Mari, Ivan Dikić, Christian A. Hübner
Publikováno v:
Nature
Foronda, H, Fu, Y, Covarrubias-Pinto, A, Bocker, H T, González, A, Seemann, E, Franzka, P, Bock, A, Bhaskara, R M, Liebmann, L, Hoffmann, M E, Katona, I, Koch, N, Weis, J, Kurth, I, Gleeson, J G, Reggiori, F, Hummer, G, Kessels, M M, Qualmann, B, Mari, M, Dikić, I & Hübner, C A 2023, ' Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy ', Nature, vol. 618, no. 7964, pp. 402-410 . https://doi.org/10.1038/s41586-023-06090-9
Foronda, H, Fu, Y, Covarrubias-Pinto, A, Bocker, H T, González, A, Seemann, E, Franzka, P, Bock, A, Bhaskara, R M, Liebmann, L, Hoffmann, M E, Katona, I, Koch, N, Weis, J, Kurth, I, Gleeson, J G, Reggiori, F, Hummer, G, Kessels, M M, Qualmann, B, Mari, M, Dikić, I & Hübner, C A 2023, ' Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy ', Nature, vol. 618, no. 7964, pp. 402-410 . https://doi.org/10.1038/s41586-023-06090-9
Membrane-shaping proteins characterized by reticulon homology domains play an important part in the dynamic remodelling of the endoplasmic reticulum (ER). An example of such a protein is FAM134B, which can bind LC3 proteins and mediate the degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587ec4f4d78e10eb10e252a8fb732491
https://doi.org/10.1038/s41586-023-06090-9
https://doi.org/10.1038/s41586-023-06090-9
Autor:
Sjoerd J L van Wijk, Nina Meyer, Donat Kögel, Muriel Mari, Svenja Zielke, Laura Zein, Simon Kardo, Fulvio Reggiori, Adriana Covarrubias-Pinto, Alexandra Stolz, Maximilian N. Kinzler, Simone Fulda
Publikováno v:
Autophagy
Zielke, S, Kardo, S, Zein, L, Mari, M, Covarrubias-Pinto, A, Kinzler, M N, Meyer, N, Stolz, A, Fulda, S, Reggiori, F, Kögel, D & van Wijk, S 2021, ' ATF4 links ER stress with reticulophagy in glioblastoma cells ', Autophagy, vol. 17, no. 9, pp. 2432-2448 . https://doi.org/10.1080/15548627.2020.1827780
Autophagy, 17(9), 2432-2448. Taylor & Francis Group
Zielke, S, Kardo, S, Zein, L, Mari, M, Covarrubias-Pinto, A, Kinzler, M N, Meyer, N, Stolz, A, Fulda, S, Reggiori, F, Kögel, D & van Wijk, S 2021, ' ATF4 links ER stress with reticulophagy in glioblastoma cells ', Autophagy, vol. 17, no. 9, pp. 2432-2448 . https://doi.org/10.1080/15548627.2020.1827780
Autophagy, 17(9), 2432-2448. Taylor & Francis Group
Selective degradation of the endoplasmic reticulum (ER; reticulophagy) is a type of autophagy involved in the removal of ER fragments. So far, amino acid starvation as well as ER stress have been described as inducers of reticulophagy, which in turn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1111425976b5b52f58946e606b4062
https://hdl.handle.net/11370/f377bb88-271d-40e1-81eb-02e2614d6033
https://hdl.handle.net/11370/f377bb88-271d-40e1-81eb-02e2614d6033
Autor:
Adriana Covarrubias-Pinto, Pamela Ehrenfeld, Isidora Vicencio, Eduardo Papic, Francisco J. Rivera, Gonzalo Mayorga‐Weber, Alejandra V. Parra, Maite A. Castro
Publikováno v:
Journal of Neuroscience Research. 99:223-235
Huntington's disease (HD) is a neurodegenerative disorder caused by a glutamine expansion at the first exon of the huntingtin gene. Huntingtin protein (Htt) is ubiquitously expressed and it is localized in several organelles, including endosomes. HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a5b5d39e86dd835565f127288f884f
https://doi.org/10.1002/jnr.24693
https://doi.org/10.1002/jnr.24693