Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Adriana Chilin"'
Autor:
Giulia Bernabè, Giovanni Marzaro, Giuseppe Di Pietra, Ana Otero, Massimo Bellato, Anthony Pauletto, Melania Scarpa, Stefania Sut, Adriana Chilin, Stefano Dall’Acqua, Paola Brun, Ignazio Castagliuolo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Increasing antibiotic resistance and the decline in the pharmaceutical industry’s investments have amplified the need for novel treatments for multidrug-resistant bacteria. Quorum sensing (QS) inhibitors reduce pathogens’ virulence without select
Externí odkaz:
https://doaj.org/article/c4d9f825588441c99fe745167568f4e3
Autor:
Chiara Tupini, Adriana Chilin, Alice Rossi, Ida De Fino, Alessandra Bragonzi, Elisabetta D’Aversa, Lucia Carmela Cosenza, Christian Vaccarin, Gianni Sacchetti, Monica Borgatti, Anna Tamanini, Maria Cristina Dechecchi, Francesca Sanvito, Roberto Gambari, Giulio Cabrini, Ilaria Lampronti
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14483 (2022)
A series of new-generation TMA (4,6,4′-trimethyl angelicin) analogues was projected and synthetized in order to ameliorate anti-inflammatory activity, with reduced or absent toxicity. Since the NF-κB transcription factor (TF) plays a critical role
Externí odkaz:
https://doaj.org/article/44a522bed2fa4ba4a4fa5511e2829d0f
Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening
Autor:
Christian Vaccarin, Daniela Gabbia, Erica Franceschinis, Sara De Martin, Marco Roverso, Sara Bogialli, Gianni Sacchetti, Chiara Tupini, Ilaria Lampronti, Roberto Gambari, Giulio Cabrini, Maria Cristina Dechecchi, Anna Tamanini, Giovanni Marzaro, Adriana Chilin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11528 (2022)
A small library of new angelicin derivatives was designed and synthesized with the aim of bypassing the side effects of trimethylangelicin (TMA), a promising agent for the treatment of cystic fibrosis. To prevent photoreactions with DNA, hindered sub
Externí odkaz:
https://doaj.org/article/ac4097f0c602425aa4b1f0e52423b399
Autor:
Erica Franceschinis, Marco Roverso, Daniela Gabbia, Sara De Martin, Matteo Brusegan, Christian Vaccarin, Sara Bogialli, Adriana Chilin
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1806 (2022)
4,6,4′-trimethylangelicin (TMA) is a promising pharmacological option for the treatment of cystic fibrosis (CF) due to its triple-acting behavior toward the function of the CF transmembrane conductance regulator. It is a poorly water-soluble drug,
Externí odkaz:
https://doaj.org/article/c6324eab598142c9ad87a0b77ebfc284
Autor:
Onofrio Laselva, Giovanni Marzaro, Christian Vaccarin, Ilaria Lampronti, Anna Tamanini, Giuseppe Lippi, Roberto Gambari, Giulio Cabrini, Christine E. Bear, Adriana Chilin, Maria C. Dechecchi
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The psoralen-related compound, 4,6,4′-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del muta
Externí odkaz:
https://doaj.org/article/9e9c443145484db0a001af967a9d8976
Autor:
Ilaria Lampronti, Maria Giulia Manzione, Gianni Sacchetti, Davide Ferrari, Susanna Spisani, Valentino Bezzerri, Alessia Finotti, Monica Borgatti, Maria Cristina Dechecchi, Giorgia Miolo, Giovanni Marzaro, Giulio Cabrini, Roberto Gambari, Adriana Chilin
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
The angelicin analogue 4,6,4′-trimethylangelicin (TMA) was recently reported as a strong inhibitor of nuclear factor-κB (NF-κB) activity and of the expression of the interleukin-8 (IL-8) gene in bronchial epithelial cells in which the inflammator
Externí odkaz:
https://doaj.org/article/cbeed5c6a5934887988e7f08e22463ea
Autor:
Po Yee Chung, Pik Ling Lam, Yuanyuan Zhou, Jessica Gasparello, Alessia Finotti, Adriana Chilin, Giovanni Marzaro, Roberto Gambari, Zhaoxiang Bian, Wai Ming Kwok, Wai Yeung Wong, Xi Wang, Alfred King-yin Lam, Albert Sun-chi Chan, Xingshu Li, Jessica Yuen Wuen Ma, Chung Hin Chui, Kim Hung Lam, Johnny Cheuk On Tang
Publikováno v:
Cells, Vol 7, Iss 10, p 177 (2018)
Quinoline core has been shown to possess a promising role in the development of anticancer agents. However, the correlation between its broad spectrum of bioactivity and the underlying mechanism of actions is poorly understood. The present study, wit
Externí odkaz:
https://doaj.org/article/59770782c46445f1b5f2921848fe3c86
Akademický článek
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Autor:
Marco Roverso, Giovanni Marzaro, Marco Verona, Paolo Caliceti, Francesca Mastrotto, Daniela Gabbia, Valentina Gandin, Stefano Salmaso, Sara Bogialli, Sara De Martin, Adriana Chilin, Michele De Franco, Christian Vaccarin
Publikováno v:
Journal of Controlled Release. 340:318-330
Tyrosine kinase inhibitors (TKIs) represent one of the most advanced class of therapeutics for cancer treatment. Most of them are also cytochrome P450 (CYP) inhibitors and/or substrates thereof. Accordingly, their efficacy and/or toxicity can be affe
Autor:
Rosa Di Liddo, Marco Verona, Christian Vaccarin, Laura Acquasaliente, Sandra Schrenk, Monica Piccione, Carola Cenzi, Michele De Franco, Matteo Dal Prà, Giovanni Ribaudo, Maria Grazia Ferlin, Maria Teresa Conconi, Adriana Chilin, Valentina Gandin, Giovanni Marzaro
Publikováno v:
Cancers, 14 (15)
Simple Summary The Epidermal Growth Factor Receptor (EGFR) is a receptor protein involved in many types of cancers. EGFR can be inhibited by monoclonal antibodies (protein drugs acting on the extracellular domain of the protein) or by ATP-mimic compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9b330b50e84a06e3ac8870d5bfa410
http://hdl.handle.net/11577/3455167
http://hdl.handle.net/11577/3455167