Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Adriana Ceci"'
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/3973f85205394383a6c665be4e295228
Autor:
Viviana Giannuzzi, Arianna Bertolani, Silvia Torretta, Giorgio Reggiardo, Eleonora Toich, Donato Bonifazi, Adriana Ceci
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionThe European Medicines Agency (EMA) offers scientific advice to support the qualification procedure of novel methodologies, such as preclinical and in vitro models, biomarkers, and pharmacometric methods, thereby endorsing their acceptabi
Externí odkaz:
https://doaj.org/article/8a34c496f14547ed9df7bdb0329ccc41
Autor:
Viviana Giannuzzi, Lucia Ruggieri, Rosa Conte, Cristina Manfredi, Mariagrazia Felisi, Christine Kubiak, Mihaela Matei, Salma Malik, Jacques Demotes, Adriana Ceci, Donato Bonifazi
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 5, Pp 797-809 (2023)
Abstract In pediatric clinical research, it is essential to implement ethical and regulatory requirements, training, and facilities to grant the proper management of specimens, considering that blood sampling may be difficult, the number of specimens
Externí odkaz:
https://doaj.org/article/f3f18209563b4cbfab2e658ff1266f36
Autor:
Mariagrazia Felisi, Fedele Bonifazi, Maddalena Toma, Claudia Pansieri, Rebecca Leary, Victoria Hedley, Ronald Cornet, Giorgio Reggiardo, Annalisa Landi, Annunziata D’Ercole, Salma Malik, Sinéad Nally, Anando Sen, Avril Palmeri, Donato Bonifazi, Adriana Ceci
Publikováno v:
Data, Vol 9, Iss 4, p 59 (2024)
The reuse of paediatric individual patient data (IPD) from clinical trials (CTs) is essential to overcome specific ethical, regulatory, methodological, and economic issues that hinder the progress of paediatric research. Sharing data through reposito
Externí odkaz:
https://doaj.org/article/9158e49a93a246568a90d8f1c50b1cc2
Autor:
Paul Healy, Luka Verrest, Mariagrazia Felisi, Adriana Ceci, Oscar Della Pasqua, GAPP Consortium
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)
Abstract Despite off‐label use, the efficacy and safety of gabapentin and tramadol in pediatric patients (3 months to
Externí odkaz:
https://doaj.org/article/dff6957eacbf4631862b15d881b44e29
Autor:
Adriana Ceci, Rosa Conte, Antonella Didio, Annalisa Landi, Lucia Ruggieri, Viviana Giannuzzi, Fedele Bonifazi
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionSeveral new active substances (ASs) targeting neuroblastoma (NBL) are under study. We aim to describe the developmental and regulatory status of a sample of ASs targeting NBL to underline the existing regulatory gaps in product developmen
Externí odkaz:
https://doaj.org/article/b7c476e27a844123afb4d8c3837fe18c
Random Forest Clustering Identifies Three Subgroups of β-Thalassemia with Distinct Clinical Severity
Autor:
Angela Vitrano, Khaled M. Musallam, Antonella Meloni, Sebastiano Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio, International Working Group on Thalassemia (IWG-THAL)
Publikováno v:
Thalassemia Reports, Vol 12, Iss 1, Pp 14-23 (2022)
In this work, we aimed to establish subgroups of clinical severity in a global cohort of β-thalassemia through unsupervised random forest (RF) clustering. We used a large global dataset of 7910 β-thalassemia patients and evaluated 19 indicators of
Externí odkaz:
https://doaj.org/article/aa15c48822b849b987d37e3cf47bfde0
Autor:
Viviana Giannuzzi, Mariagrazia Felisi, Donato Bonifazi, Hugo Devlieger, George Papanikolaou, Lamis Ragab, Slaheddine Fattoum, Bianca Tempesta, Giorgio Reggiardo, Adriana Ceci
Publikováno v:
BMC Medical Ethics, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background We describe our experience from a multi-national application of a European Union-funded research-driven paediatric trial (DEEP-2, EudraCT 2012-000353-31; NCT01825512). This paper aims to evaluate the impact of the local and nation
Externí odkaz:
https://doaj.org/article/89241f1a85d5453ba0404500226b0444
Autor:
Thomas G. de Leeuw, Laura Mangiarini, Rebecca Lundin, Florentia Kaguelidou, Tjitske van der Zanden, Oscar Della Pasqua, Dick Tibboel, Adriana Ceci, Saskia N. de Wildt, on behalf of the GAPP consortium
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Gabapentin has shown efficacy in the treatment of chronic neuropathic or mixed pain in adults. Although pediatric pain specialists have extensive experience with gabapentin for the treatment of neuropathic pain, its use is off-lab
Externí odkaz:
https://doaj.org/article/65ac8beb82db46a691e0d6e49e42318b
Autor:
Khaled M. Musallam, Angela Vitrano, Antonella Meloni, Sebastiano Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio
Publikováno v:
Haematologica, Vol 106, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/f8aa168aaecb4973892659488df605a9