Výsledky vyhledávání - "Adriana Bolasco"

Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives

Autor: Celeste De Monte, Federica Caprara, Alessandra Zicari, Simone Carradori, Daniela Secci, Adriana Bolasco, Daniela Rivanera, Adriano Mollica, Bruna Bizzarri, Emanuela Mari, Atilla Akdemir

Publikováno v: European Journal of Medicinal Chemistry. 107:82-96

On the basis of the recent findings about the biological properties of thiazolidinones and taking into account the encouraging results about the antifungal activity of some (thiazol-2-yl)hydrazines, new N-substituted heterocyclic derivatives were des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6322b29cb3e0230a61d0b8342adb257f
https://doi.org/10.1016/j.ejmech.2015.10.048

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Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii

Autor: Claudia Bordón, Lorraine Jones-Brando, Melissa D'Ascenzio, Daniela Secci, Adriana Bolasco, Nathan Faulhaber, Daniela Rivanera, Bruna Bizzarri, Celeste De Monte, Simone Carradori

Publikováno v: European Journal of Medicinal Chemistry. 86:17-30

We designed and synthesized a large number of novel thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii activity. This scaffold was functionalized at the N1-hydrazine portion with aliphatic, cycloaliphatic and (hetero)aro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699b4d9a55187809ffbb3f4edd7f3f70
https://doi.org/10.1016/j.ejmech.2014.08.046

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Microwave and Ultrasound-Assisted Synthesis of Thiosemicarbazones and Their Corresponding (4,5-Substituted-thiazol-2-yl)hydrazines

Autor: Adriana Bolasco, Simone Carradori, Daniela Secci, Melissa D'Ascenzio, Paola Chimenti

Publikováno v: Journal of Heterocyclic Chemistry. 51:1856-1861

Hantzsch cyclization of thiosemicarbazone intermediates is a very popular approach to the synthesis of substituted thiazoles. We developed a convenient microwave and ultrasound-assisted method both for the synthesis of 1-(alkyliden/cycloalkyliden/ary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dca3b4c849f1b8a75b067c6f7a67a4fd
https://doi.org/10.1002/jhet.1856

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Selective MAO-B inhibitors: a lesson from natural products

Autor: Simone Carradori, Melissa D'Ascenzio, Adriana Bolasco, Paola Chimenti, Daniela Secci

Publikováno v: Molecular Diversity. 18:219-243

Monoamine oxidases (MAOs) are mitochondrial bound enzymes, which catalyze the oxidative deamination of monoamine neurotransmitters. Inside the brain, MAOs are present in two isoforms: MAO-A and MAO-B. The activity of MAO-B is generally higher in pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1044510fb8e0a73b278b1f736a59cc77
https://doi.org/10.1007/s11030-013-9490-6

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Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents

Autor: Daniela Rivanera, Daniela Secci, Alessandra Zicari, Bruna Bizzarri, Lavinia Vittoria Lotti, Adriana Bolasco, Simone Carradori, Emanuela Mari

Publikováno v: European Journal of Medicinal Chemistry. 65:102-111

Thirty-eight new (4-(4-substituted-phenyl/2,4-disubstituted-phenyl)-thiazol-2-yl)hydrazine derivatives were synthesized in good yield and assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c247bfaa8d7ede8d9f04774291c0cc8
https://doi.org/10.1016/j.ejmech.2013.04.042

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Synthesis and Selective Inhibitory Activity Against Human COX-1 of Novel 1-(4-Substituted-thiazol-2-yl)-3,5-di(hetero)aryl-pyrazoline Derivatives

Autor: Simone Carradori, Matilde Yáñez, Daniela Secci, Celeste De Monte, Adriana Bolasco

Publikováno v: Archiv der Pharmazie. 345:973-979

Novel 1-(4-ethyl carboxylate-thiazol-2-yl)-3,5-di(hetero)aryl-2-pyrazoline derivatives were obtained by reacting 3,5-di(hetero)aryl-1-thiocarbamoyl-2-pyrazolines with the ethyl ester of α-bromo-pyruvic acid. The synthesized compounds were confirmed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f265fb97ec722c5f1bc76ddf65a0b7dc
https://doi.org/10.1002/ardp.201200249

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Conventional and Microwave-Assisted Synthesis of Benzimidazole Derivatives and TheirIn VitroInhibition of Human Cyclooxygenase

Autor: Melissa D'Ascenzio, Flavio della Sala, Simone Carradori, Adriana Bolasco, Matilde Yáñez, Daniela Secci

Publikováno v: Journal of Heterocyclic Chemistry. 49:1187-1195

A large series of 1,2-diaryl-benzimidazole and 2-aryl-1H-benzimidazole derivatives were synthesized with slight differences using both microwave irradiation and conventional heating methods. Usually higher yields and time reactions reduction were obt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2aff96e86c0afd9e4298aa5350a3e715
https://doi.org/10.1002/jhet.1058

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