Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches.

Autor: Adriana Becerril, Susana Álvarez, Alfredo F Braña, Sergio Rico, Margarita Díaz, Ramón I Santamaría, José A Salas, Carmen Méndez

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0198145 (2018)

Sequencing of Streptomyces genomes has revealed they harbor a high number of biosynthesis gene cluster (BGC), which uncovered their enormous potentiality to encode specialized metabolites. However, these metabolites are not usually produced under sta

Externí odkaz: https://doaj.org/article/6f2bb4232e054ed29f6a56661b9ced5f

Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family

Autor: Alfredo F. Braña, Fernando Reyes, Jesús Martín, Adriana Becerril, Ignacio Pérez-Victoria, Suhui Ye, José A. Salas, Carmen Méndez

Publikováno v: ACS Chemical Biology. 15:1541-1553

Largimycins are hybrid nonribosomal peptide-polyketides that constitute a new group of metabolites in the leinamycin family of natural products displaying unique structural features such as containing an oxazole instead of a thiazole ring or being ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::729aeb1300838d376a5c675fdf90f229
https://doi.org/10.1021/acschembio.0c00160

Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches

Autor: Carmen Méndez, Margarita Díaz, José A. Salas, Adriana Becerril, Ramón I. Santamaría, Susana Álvarez, Alfredo F. Braña, Sergio Rico

Publikováno v: Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0198145 (2018)

Sequencing of Streptomyces genomes has revealed they harbor a high number of biosynthesis gene cluster (BGC), which uncovered their enormous potentiality to encode specialized metabolites. However, these metabolites are not usually produced under sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fea5ffc58a893f7da30363beada43c
http://hdl.handle.net/10651/48720

Participation of NMDA-glutamatergic receptors in hippocampal neuronal damage caused by adult-onset hypothyroidism

Autor: Carmen Aceves, Brenda Anguiano, Adriana Becerril, Jorge Pacheco-Rosado, Claudia Alva-Sánchez

Publikováno v: Neuroscience Letters. 453:178-181

We analyzed the participation of N-methyl-d-aspartate (NMDA) receptors in the neuronal damage caused by adult-onset hypothyroidism. Wistar rats were randomly assigned into four groups. The euthyroid group received tap water. The hypothyroid group rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169a4c9d7d328589c4cd8e9c004ed22d
https://doi.org/10.1016/j.neulet.2009.02.017

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas

Autor: Luz Ruiz-Godoy, Adriana Becerril Montes, Jorge Herrera Abarca, Lourdes Suarez Roa, Abelardo Meneses-García, Alejandro Mohar Betancourt

Publikováno v: World Journal of Surgical Oncology, Vol 6, Iss 1, p 114 (2008)
World Journal of Surgical Oncology

BackgroundExtranodal T/NK cell lymphomas possess distinctive clinico-pathological characteristics: they are angiocentric, exhibit extensive necrosis. Prognosis is poor in the short term. The objective is to explore the expression of different MMPs in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bce3e82377e3423f0d296a682cc9a6f
https://doi.org/10.1186/1477-7819-6-114