Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Adriana Aguilar-Mahecha"'
Publikováno v:
MethodsX, Vol 11, Iss , Pp 102306- (2023)
We present a method and a simple system for high-pH RP-LC peptide fractionation of small sample amounts (30–60 µg), at micro-flow rates with micro-liter fraction collection using ammonium bicarbonate as an optimized buffer for system stability and
Externí odkaz:
https://doaj.org/article/36e0e08d98074f27b1346d3faa92c2b4
Autor:
Adriana Aguilar-Mahecha, Najmeh Alirezaie, Josiane Lafleur, Eric Bareke, Ewa Przybytkowski, Cathy Lan, Luca Cavallone, Myriam Salem, Manuela Pelmus, Olga Aleynikova, Celia Greenwood, Amanda Lovato, Cristiano Ferrario, Jean-François Boileau, Catalin Mihalcioiu, Josée-Anne Roy, Elizabeth Marcus, Federico Discepola, Jacek Majewski, Mark Basik
Publikováno v:
Genes, Vol 15, Iss 1, p 27 (2023)
The response of triple-negative breast cancer (TNBC) patients to pre-operative (neoadjuvant chemotherapy) is a critical factor of their outcome. To determine the effects of chemotherapy on the tumor genome and to identify mutations associated with ch
Externí odkaz:
https://doaj.org/article/0e7d84274b4e487890fe81187e5fd46f
Autor:
Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregu
Externí odkaz:
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
Autor:
Martin Paré, Cédric Y. Darini, Xi Yao, Bérengère Chignon-Sicard, Samah Rekima, Simon Lachambre, Virginie Virolle, Adriana Aguilar-Mahecha, Mark Basik, Christian Dani, Annie Ladoux
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Cancer cells cooperate with cells that compose their environment to promote tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy by cancer cells and adipokines that contribute to tumor expans
Externí odkaz:
https://doaj.org/article/d8b5595197c049e0a6f3bac387dbbeda
Autor:
Cedric Darini, Nour Ghaddar, Catherine Chabot, Gloria Assaker, Siham Sabri, Shuo Wang, Jothilatha Krishnamoorthy, Marguerite Buchanan, Adriana Aguilar-Mahecha, Bassam Abdulkarim, Jean Deschenes, Jose Torres, Josie Ursini-Siegel, Mark Basik, Antonis E. Koromilas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The HER2 monoclonal antibody, Trastuzumab, is the current standard treatment for HER2+ cancers but resistance to therapy occurs. Here, the authors show that activation of the PKR/eIF2α-P pathway exhibits anti-tumor effects in HER2+ cancer and is req
Externí odkaz:
https://doaj.org/article/7ecf6c59b1264893ab9910b75de10e72
Autor:
Georgia Mitsa, Qianyu Guo, Christophe Goncalves, Samuel E. J. Preston, Vincent Lacasse, Adriana Aguilar-Mahecha, Naciba Benlimame, Mark Basik, Alan Spatz, Gerald Batist, Wilson H. Miller, Sonia V. del Rincon, René P. Zahedi, Christoph H. Borchers
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4443 (2022)
Most human tumor tissues that are obtained for pathology and diagnostic purposes are formalin-fixed and paraffin-embedded (FFPE). To perform quantitative proteomics of FFPE samples, paraffin has to be removed and formalin-induced crosslinks have to b
Externí odkaz:
https://doaj.org/article/e4948b417d7c4fd386dfbbaadf5b2a4d
Autor:
Adriana Aguilar-Mahecha, Sarah Joseph, Luca Cavallone, Marguerite Buchanan, Urszula Krzemien, Gerald Batist, Mark Basik
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Trastuzumab, has played a major role in improving treatment outcomes in HER-2 positive gastric cancer. However, once there is disease progression there is a paucity of evidence for second line therapy. Patient-derived xenografts (PDXs) in combination
Externí odkaz:
https://doaj.org/article/e2b407473553426cab80825eaabdd441
Autor:
Adriana Aguilar-Mahecha, Josiane Lafleur, Susie Brousse, Olga Savichtcheva, Kimberly A. Holden, Nathan Faulkner, Graham McLennan, Taylor J. Jensen, Mark Basik
Publikováno v:
Cancers, Vol 13, Iss 6, p 1331 (2021)
Background: Circulating tumor DNA (ctDNA) offers high sensitivity and specificity in metastatic cancer. However, many ctDNA assays rely on specific mutations in recurrent genes or require the sequencing of tumor tissue, difficult to do in a metastati
Externí odkaz:
https://doaj.org/article/c4fd99fa4ded4acf91d4360c490d7ffe
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38290 (2012)
Blood sample processing and handling can have a significant impact on the stability and levels of proteins measured in biomarker studies. Such pre-analytical variability needs to be well understood in the context of the different proteomics platforms
Externí odkaz:
https://doaj.org/article/fa94bfffe1dd4e319d2a4c231b8ffcfb
Autor:
Talia Roseshter, Anna Klemantovich, Luca Cavallone, Adriana Aguilar-Mahecha, Josiane Lafleur, Oluwadara O. Elebute, Sarah Jenna, Jean-Francois Boileau, Manuela Pelmus, Mark Basik, Cathy Lan
Publikováno v:
Cancer Research. 83:P2-11
Background The presence of residual tumour at surgery (non-pathological complete response or non-pCR) occurs in about half of TNBCs treated with neoadjuvant chemotherapy (NAC) and signals chemoresistance and poor prognosis. Although further adjuvant