Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Adriana Aguado-Martínez"'
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Akademický článek
Virulence in Mice of a Toxoplasma gondii Type II Isolate Does Not Correlate With the Outcome of Experimental Infection in Pregnant Sheep
Autor: Roberto Sánchez-Sánchez, Ignacio Ferre, Javier Regidor-Cerrillo, Daniel Gutiérrez-Expósito, Luis Miguel Ferrer, Noive Arteche-Villasol, Javier Moreno-Gonzalo, Joachim Müller, Adriana Aguado-Martínez, Valentín Pérez, Andrew Hemphill, Luis Miguel Ortega-Mora, Julio Benavides
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2019)
Toxoplasma gondii is an apicomplexan parasite that infects almost all warm-blooded animals. Little is known about how the parasite virulence in mice extrapolates to other relevant hosts. In the current study, in vitro phenotype and in vivo behavior i
Externí odkaz: https://doaj.org/article/39c152ab6ae0487a94c768fd8eaed160
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Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis
Autor: Luis Miguel Ortega-Mora, Matthew A. Hulverson, Andrew Hemphill, Dustin J. Maly, Ignacio Ferre, Wes Van Voorhis, Kayode K. Ojo, Molly C. McCloskey, Ryan Choi, Joachim Müller, Adriana Aguado-Martínez, Lynn K. Barrett, Javier Moreno-Gonzalo
Publikováno v: Müller, Joachim; Aguado Martinez, Adriana; Ortega-Mora, Luis-Miguel; Moreno-Gonzalo, Javier; Ferre, Ignacio; Hulverson, Matthew A; Choi, Ryan; McCloskey, Molly C; Barrett, Lynn K; Maly, Dustin J; Ojo, Kayode K; Van Voorhis, Wes; Hemphill, Andrew (2017). Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis. Journal of antimicrobial chemotherapy, 72(8), pp. 2334-2341. Oxford University Press 10.1093/jac/dkx134
Objectives Establishment of a mouse model for congenital toxoplasmosis based on oral infection with oocysts from Toxoplasma gondii ME49 and its application for investigating chemotherapeutic options against congenital toxoplasmosis. Methods CD1 mice
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6905d929b95c571e9bade6dd0ba58379
https://doi.org/10.1093/jac/dkx134
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3
Virulence in Mice of a Toxoplasma gondii Type II Isolate Does Not Correlate With the Outcome of Experimental Infection in Pregnant Sheep
Autor: Noive Arteche-Villasol, Roberto Sánchez-Sánchez, Luis Miguel Ortega-Mora, Julio Benavides, Joachim Müller, Ignacio Ferre, Valentín Pérez Pérez, Luis Miguel Ferrer, Adriana Aguado-Martínez, Andrew Hemphill, Javier Moreno-Gonzalo, Daniel Gutiérrez-Expósito, Javier Regidor-Cerrillo
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Sánchez-Sánchez, Roberto; Ferre, Ignacio; Regidor-Cerrillo, Javier; Gutiérrez-Expósito, Daniel; Ferrer, Luis Miguel; Arteche-Villasol, Noive; Moreno-Gonzalo, Javier; Müller, Joachim; Aguado Martinez, Adriana; Pérez, Valentín; Hemphill, Andrew; Ortega-Mora, Luis Miguel; Benavides, Julio (2019). Virulence in Mice of a Toxoplasma gondii Type II Isolate Does Not Correlate With the Outcome of Experimental Infection in Pregnant Sheep. Frontiers in cellular and infection microbiology, 8(436), p. 436. Frontiers 10.3389/fcimb.2018.00436
Frontiers in Cellular and Infection Microbiology, Vol 8 (2019)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
18 páginas, 6 figuras, 3 tablas.
Toxoplasma gondii is an apicomplexan parasite that infects almost all warm-blooded animals. Little is known about how the parasite virulence in mice extrapolates to other relevant hosts. In the current study, in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428530fb1da4958f8a00cd12899bfca6
http://hdl.handle.net/10261/179269
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4
EFFECT OF DIFFERENT ECOSYSTEMS AND MANAGEMENT PRACTICES ONTOXOPLASMA GONDIIANDNEOSPORA CANINUMINFECTIONS IN WILD RUMINANTS IN SPAIN
Autor: Pedro Rubio, Daniel Gutiérrez-Expósito, Elena González-Zotes, Gema Álvarez-García, Mercedes Gómez-Bautista, José M. San Miguel, J. Pereira-Bueno, Adriana Aguado-Martínez, Luis Miguel Ortega-Mora, Esther Collantes-Fernández
Publikováno v: Journal of Wildlife Diseases. 52:293-300
Toxoplasma gondii and Neospora caninum are two major abortifacient protozoans in domestic small ruminants and cattle, respectively, and they also parasitize a wide range of wildlife. Numerous serosurveys have been conducted in wild ruminants worldwid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59853d8235e52a0092ce8eb07991354
https://doi.org/10.7589/2015-07-176
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Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models
Autor: Andrew Hemphill, Adriana Aguado-Martínez, Joachim Müller
Publikováno v: Parasitology
Hemphill, Andrew; Aguado Martinez, Adriana; Müller, Joachim (2016). Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models. Parasitology, 143(3), pp. 245-259. Cambridge University Press 10.1017/S0031182015001596
SUMMARYNeospora caninumis a leading cause of abortion in cattle, and is thus an important veterinary health problem of high economic significance. Vaccination has been considered a viable strategy to prevent bovine neosporosis. Different approaches h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4a704a346ad87bee465f384afc3b46
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6
Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice
Autor: Adriana Aguado-Martínez, Sovitj Pou, Andrew Hemphill, Michael K. Riscoe, Nicoleta Anghel, Pablo Winzer, Aaron Nilsen, Vreni Balmer, Mona Roozbehani, J. Stone Doggett, Joachim Müller
Publikováno v: Anghel, Nicoleta; Balmer, Vreni; Müller, Joachim; Winzer, Pablo Arnold; Aguado Martinez, Adriana; Roozbehani, Mona; Pou, Sovitj; Nilsen, Aaron; Riscoe, Michael; Doggett, J Stone; Hemphill, Andrew (2018). Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice. Frontiers in veterinary science, 5, p. 285. Frontiers Media 10.3389/fvets.2018.00285
Frontiers in Veterinary Science, Vol 5 (2018)
Frontiers in Veterinary Science
We report on the efficacy of selected endochin-like quinolones (ELQs) against N. caninum tachyzoites grown in human foreskin fibroblasts (HFF), and in a pregnant BALB/c mouse model. Fourteen ELQs were screened against transgenic N. caninum tachyzoite
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709a2ed3cfc91c8f128ef70e57fd605b
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8
Immunization with a cocktail of antigens fused with OprI reduces Neospora caninum vertical transmission and postnatal mortality in mice
Autor: Alexandre Leitão, Lorenz T. Ryser, David Arranz-Solís, Shun Tanaka, Luis Miguel Ortega-Mora, Afonso P. Basto, Adriana Aguado-Martínez, Telmo Nunes, Andrew Hemphill
Publikováno v: Vaccine. 37(3)
OprI is an outer membrane lipoprotein from Pseudomonas aeruginosa, and when fused to a recombinant antigen, will exert adjuvant properties by engaging Toll-like receptor 2, leading to dendritic cell activation. Previous studies have shown that the Ne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ae3a91667e6492eb33407a7d0e310a
https://pubmed.ncbi.nlm.nih.gov/30497830
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Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice
Autor: David Arranz-Solís, Isabel Hostettler, Pablo Winzer, Adriana Aguado-Martínez, Dominic Ritler, Vreni Balmer, Vera Manser, Luis Miguel Ortega-Mora, Andrew Hemphill, Joachim Müller
Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 1, Pp 16-25 (2015)
International journal for parasitology. Drugs and drug resistance
International Journal for Parasitology: Drugs and Drug Resistance
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Balmer, Vreni; Winzer, Pablo Arnold; Ritler, Dominic; Hostettler, Isabel; Arranz Solis, David; Ortega-Mora, Luis; Hemphill, Andrew (2015). Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. International journal for parasitology. Drugs and drug resistance, 5(1), pp. 16-25. Elsevier 10.1016/j.ijpddr.2015.02.001
Highlights • Buparvaquone inhibits proliferation of Neospora caninum at nanomolar concentrations. • In vitro, the drug acts mainly parasitostatic. • Parasiticidal effects occur at µmolar concentrations after extended periods of time. • Bupar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5765cb352f0a3285dabec918844ccb
http://www.sciencedirect.com/science/article/pii/S2211320715000032
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10
Neospora caninum in non-pregnant and pregnant mouse models: cross-talk between infection and immunity
Autor: Andrew Hemphill, Alexandre Leitão, Afonso P. Basto, Adriana Aguado-Martínez
Publikováno v: International journal for parasitology. 47(12)
Neospora caninum is a cyst-forming coccidian which causes abortion in cattle, with a high economic impact globally. Vaccination is considered to be the most cost-effective strategy to control and prevent bovine neosporosis. However, there is no comme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0748521d74d34113053e8540b6383ea9
https://pubmed.ncbi.nlm.nih.gov/28903024
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