Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

Autor: Urmi Sengupta, Rakez Kayed, Adriana A. Paulucci-Holthauzen, Yembur Ahmad, Cristian A. Lasagna-Reeves, Shashirekha Krishnamurthy, Diana L. Castillo-Carranza, Marcos J. Guerrero-Muñoz, George R. Jackson

Publikováno v: Neurobiology of Disease, Vol 71, Iss, Pp 14-23 (2014)

Alzheimer's disease is a complex disease characterized by overlapping phenotypes with different neurodegenerative disorders. Oligomers are considered the most toxic species in amyloid pathologies. We examined human AD brain samples using an anti-olig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f6599532e765587e29e7369782618d
https://doi.org/10.1016/j.nbd.2014.08.008

Spatial Distribution of Protein Kinase A Activity during Cell Migration Is Mediated by A-kinase Anchoring Protein AKAP Lbc

Autor: John D. Scott, Larry J. Bellot, David A. Canton, Leoncio A. Vergara, Adriana A. Paulucci-Holthauzen, Kathleen L. O'Connor

Publikováno v: Journal of Biological Chemistry. 284:5956-5967

Protein kinase A (PKA) has been suggested to be spatially regulated in migrating cells due to its ability to control signaling events that are critical for polarized actin cytoskeletal dynamics. Here, using the fluorescence resonance energy transfer-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a8b00cd8b44fd18ecc712b8fdf6dcd
https://doi.org/10.1074/jbc.m805606200

Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3

Autor: Partha S. Sarkar, Tetsuo Ashizawa, Tohru Matsuura, Patrícia Maciel, Tapas K. Hazra, Hang L. Zhang, Adriana A. Paulucci-Holthauzen, Yongping Liu, Arpita Chatterjee, Arnulf H. Koeppen, Rui Gao, Sanjeev Choudhary, Anabela Silva-Fernandes, Xiang Fang

Publikováno v: PLoS Genetics, Vol 11, Iss 1, p e1004834 (2015)
PLoS Genetics
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an untreatable autosomal dominant neurodegenerative disease, and the most common such inherited ataxia worldwide. The mutation in SCA3 is the expansion of a polymorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04e62c4d4d89411526260048a27f8a7
http://europepmc.org/articles/PMC4295939?pdf=render

Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies

Autor: George R. Jackson, Urmi Sengupta, Cristian A. Lasagna-Reeves, Shashirekha Krishnamurthy, Adriana A. Paulucci-Holthauzen, Rakez Kayed, Malika Farhed, Diana L. Castillo-Carranza, Marcos J. Guerrero-Muñoz, Julia E. Gerson

Publikováno v: Biological psychiatry. 78(10)

BACKGROUND: Aberrant accumulation of α-synuclein constitutes inclusion bodies that are considered a characteristic feature of a group of neurological disorders described as synucleinopathies. Often, multiple disease-causing proteins overlap within a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d970ca61222044d3e9ac9b83b9f7974e
https://pubmed.ncbi.nlm.nih.gov/26497280

PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity

Autor: Sarita K. Sastry, Rosario Espejo, Panos Z. Anastasiadis, Adriana A. Paulucci-Holthauzen, Krysta Honkus, Yowjiun Jeng, William Rengifo-Cam

Publikováno v: Journal of Cell Science

Tyrosine phosphorylation is implicated in regulating the adherens junction protein, p120 catenin (p120), however, the mechanisms are not well defined. Here, we show, using substrate trapping, that p120 is a direct target of the protein tyrosine phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfc39bbd67cee1911067f208f289c3c
https://pubmed.ncbi.nlm.nih.gov/24284071