Zobrazeno 1 - 10
of 388
pro vyhledávání: '"Adriana, Heguy"'
Autor:
Theodore Sakellaropoulos, Catherine Do, Guimei Jiang, Giulia Cova, Peter Meyn, Dacia Dimartino, Sitharam Ramaswami, Adriana Heguy, Aristotelis Tsirigos, Jane A. Skok
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Aberrations in the capacity of DNA/chromatin modifiers and transcription factors to bind non-coding regions can lead to changes in gene regulation and impact disease phenotypes. However, identifying distal regulatory elements and connecting
Externí odkaz:
https://doaj.org/article/25fc948f3f434d049d7610ff9b16694c
Autor:
Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghua Li, Imran Sulaiman, Jun-Chieh J. Tsay, Peter Meyn, Hussein Mohamed, Iris Sydney, Tomoe Shiomi, Sitharam Ramaswami, Navneet Narula, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Wei-Yi Cheng, James Cai, Salman Punekar, Vamsidhar Velcheti, Daniel H. Sterman, J. T. Poirier, Ben Neel, Kwok-Kin Wong, Luis Chiriboga, Adriana Heguy, Thales Papagiannakopoulos, Bettina Nadorp, Matija Snuderl, Leopoldo N. Segal, Andre L. Moreira, Harvey I. Pass, Aristotelis Tsirigos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Approximately 30% of early-stage lung adenocarcinoma patients present with disease progression after successful surgical resection. Despite efforts of mapping the genetic landscape, there has been limited success in discovering predictive bi
Externí odkaz:
https://doaj.org/article/326ae301e3024de2b6652801e0ebede8
Autor:
Samantha K. Smith, Paul W. Frazel, Alireza Khodadadi-Jamayran, Paul Zappile, Christian Marier, Mariam Okhovat, Stuart Brown, Michael A. Long, Adriana Heguy, Steven M. Phelps
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Developing genomic resources for a diverse range of species is an important step towards understanding the mechanisms underlying complex traits. Specifically, organisms that exhibit unique and accessible phenotypes-of-interest all
Externí odkaz:
https://doaj.org/article/798eb7a09956465eb3041f88f28ffb5e
Autor:
Ralf Duerr, Dacia Dimartino, Christian Marier, Paul Zappile, Guiqing Wang, Fritz François, Mila B. Ortigoza, Eduardo Iturrate, Marie I. Samanovic, Mark J. Mulligan, Adriana Heguy
Publikováno v:
EBioMedicine, Vol 97, Iss , Pp 104843- (2023)
Summary: Background: High rates of vaccination and natural infection drive immunity and redirect selective viral adaptation. Updated boosters are installed to cope with drifted viruses, yet data on adaptive evolution under increasing immune pressure
Externí odkaz:
https://doaj.org/article/9a42314292244bbf8ac8b08f64d79d3b
Autor:
Gregor Werba, Daniel Weissinger, Emily A. Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B. Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H. Sherman, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking.
Externí odkaz:
https://doaj.org/article/3a27bc68fbda40dca2027e7c95c28684
Autor:
Emanuela Marcantoni, PhD, Michael S. Garshick, MD, MS, Tamar Schwartz, BA, Nicole Ratnapala, MS, Matthew Cambria, BA, Rebecca Dann, MS, Meagan O’Brien, MD, Adriana Heguy, PhD, Jeffrey S. Berger, MD, MS
Publikováno v:
JACC: Basic to Translational Science, Vol 7, Iss 11, Pp 1086-1097 (2022)
Summary: Patients with HIV exhibit platelet activation and increased risk of cardiovascular disease, the prevention of which is not fully known. Fifty-five HIV-positive patients were randomized to clopidogrel, aspirin, or no-treatment for 14 days, an
Externí odkaz:
https://doaj.org/article/ba81447055bf48c9a8bbdcf384379497
Autor:
Simon Dellicour, Samuel L Hong, Verity Hill, Dacia Dimartino, Christian Marier, Paul Zappile, Gordon W Harkins, Philippe Lemey, Guy Baele, Ralf Duerr, Adriana Heguy
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011348 (2023)
Since the latter part of 2020, SARS-CoV-2 evolution has been characterised by the emergence of viral variants associated with distinct biological characteristics. While the main research focus has centred on the ability of new variants to increase in
Externí odkaz:
https://doaj.org/article/9a24d641a1354d4da8ae5335b19a3576
Autor:
Ralf Duerr, Hao Zhou, Takuya Tada, Dacia Dimartino, Christian Marier, Paul Zappile, Guiqing Wang, Jonathan Plitnick, Sara B. Griesemer, Roxanne Girardin, Jessica Machowski, Sean Bialosuknia, Erica Lasek-Nesselquist, Samuel L. Hong, Guy Baele, Meike Dittmann, Mila B. Ortigoza, Prithiv J. Prasad, Kathleen McDonough, Nathaniel R. Landau, Kirsten St George, Adriana Heguy
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106075- (2023)
Summary: The emergence of recombinant viruses is a threat to public health, as recombination may integrate variant-specific features that together result in escape from treatment or immunity. The selective advantages of recombinant SARS-CoV-2 isolate
Externí odkaz:
https://doaj.org/article/585eec9eafc5429bbcaa9a950f5d24d1
Autor:
DongAhn Yoo, Junhee Park, Chul Lee, Injun Song, Young Ho Lee, Tery Yun, Hyemin Lee, Adriana Heguy, Jae Yong Han, Jeremy S Dasen, Heebal Kim, Myungin Baek
Publikováno v:
eLife, Vol 11 (2022)
The little skate Leucoraja erinacea, a cartilaginous fish, displays pelvic fin driven walking-like behavior using genetic programs and neuronal subtypes similar to those of land vertebrates. However, mechanistic studies on little skate motor circuit
Externí odkaz:
https://doaj.org/article/89c8d785fa024ad297f2d0ea93c60935
Autor:
Adriana Heguy, Dacia Dimartino, Christian Marier, Paul Zappile, Emily Guzman, Ralf Duerr, Guiqing Wang, Jonathan Plitnick, Alexis Russell, Daryl M. Lamson, Kirsten St. George
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 4, Pp 881-883 (2022)
Of 379 severe acute respiratory syndrome coronavirus 2 samples collected in New York, USA, we detected 86 Omicron variant sequences containing Delta variant mutation P681R. Probable explanations were co-infection with 2 viruses or contamination/ampli
Externí odkaz:
https://doaj.org/article/299b66beeb9d4dca94e9be823107f679