Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Adrian von Witzleben"'
Autor:
Tsima Abou Kors, Matthias Meier, Lena Mühlenbruch, Annika C. Betzler, Franziska Oliveri, Martin Bens, Jaya Thomas, Johann M. Kraus, Johannes Doescher, Adrian von Witzleben, Linda Hofmann, Jasmin Ezic, Diana Huber, Julian Benckendorff, Thomas F. E. Barth, Jens Greve, Patrick J. Schuler, Cornelia Brunner, Jonathan M. Blackburn, Thomas K. Hoffmann, Christian Ottensmeier, Hans A. Kestler, Hans-Georg Rammensee, Juliane S. Walz, Simon Laban
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T cells. Overexpressed tumor associated antigens, mainly cancer-testis antigens (CTA)
Externí odkaz:
https://doaj.org/article/395296b0c62b42a7af04bb14da175331
Autor:
Simon Eschweiler, Alice Wang, Ciro Ramírez-Suástegui, Adrian von Witzleben, Yingcong Li, Serena J. Chee, Hayley Simon, Monalisa Mondal, Matthew Ellis, Gareth J. Thomas, Vivek Chandra, Christian H. Ottensmeier, Pandurangan Vijayanand
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112040- (2023)
Summary: Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer immunotherapy target in mice, its potential to cause toxicity, specific mode of action wit
Externí odkaz:
https://doaj.org/article/327579dd01244769ba874a0df16d447c
Autor:
Johannes Doescher, Adrian von Witzleben, Konstantinos Boukas, Stephanie E. Weissinger, Gareth J. Thomas, Simon Laban, Jaya Thomas, Thomas K. Hoffmann, Christian H. Ottensmeier
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chemoradiotherapy (CRT) is a standard treatment for advanced head and neck squamous cell carcinoma (HNSCC). Unfortunately, not all patients respond to this therapy and require further treatment, either salvage surgery or palliative therapy. The addit
Externí odkaz:
https://doaj.org/article/0f6a2dfd86bf46f089d4d00e59c62b60
Autor:
Chuan Wang, Kaïdre Bendjama, Stephen Schoenberger, Oliver Wood, Gareth Thomas, Pandurangan Vijayanand, Tilman Sanchez-Elsner, Nathalie Silvestre, Natalia Savelyeva, Christian Ottensmeier, Katy McCann, Adrian von Witzleben, Jaya Thomas, Divya Singh, Konstantinos Boukas, Finn Cilius Nielsen, Jason Greenbaum, Bjoern Peters
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Cancer is characterized by an accumulation of somatic mutations, of which a significant subset can generate cancer-specific neoepitopes that are recognized by autologous T cells. Such neoepitopes are emerging as important targets for cance
Externí odkaz:
https://doaj.org/article/f2e7b76ffbf04704a85332017c66893b
Autor:
Adrian von Witzleben, Urs Müller-Richter, Katja Maurus, Stephanie Brändlein, Marie-Nicole Theodoraki, Cornelia Brunner, Simon Laban, Jochen Lennerz, Peter Möller, Thomas K. Hoffmann, Johannes Doescher, Patrick J. Schuler
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15835 (2022)
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers and patients have limited therapy options if primary treatment fails. Therefore, additional information about the biology of the tumor is essential. Here we performed a
Externí odkaz:
https://doaj.org/article/abb4c3ab69d940c588fb3edeb1ba2d7e
Autor:
Adrian von Witzleben, Eve Currall, Oliver Wood, Lindsey Chudley, Oluyemisi Akinyegun, Jaya Thomas, Kaïdre Bendjama, Gareth J. Thomas, Peter S. Friedmann, Emma V. King, Simon Laban, Christian H. Ottensmeier
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
IntroductionHuman papillomavirus 16 (HPV16) is the main cause of oropharyngeal squamous cell carcinoma (OPSCC). To date, the links between HPV16 gene expression and adaptive immune responses have not been investigated. We evaluated the correlation of
Externí odkaz:
https://doaj.org/article/8c0f3f22a4e94e7284de91bdb15a28b1
Autor:
Daniela Jäger, Thomas F. E. Barth, Silke Brüderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, André Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss, Christian R. Wirtz, Peter Möller, Kevin Mellert
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Chordomas are rare tumours of the bone arising along the spine from clivus to sacrum. We compared three chordoma cell lines of the clivus region including the newly established clivus chordoma cell line, U-CH14, with nine chordoma cell lines
Externí odkaz:
https://doaj.org/article/0d1eed0325ea49689979e4d5afd31ace
Autor:
Michael J. Böhm, Ralf Marienfeld, Daniela Jäger, Kevin Mellert, Adrian von Witzleben, Silke Brüderlein, Mathias Wittau, Alexandra von Baer, Markus Schultheiss, Regine Mayer-Steinacker, Frank G. Rücker, Peter Möller, Lars Bullinger, Thomas F. E. Barth
Publikováno v:
Sarcoma, Vol 2019 (2019)
Leiomyosarcoma (LMS) is characterized by high genomic complexity, and to date, no specific targeted therapy is available. In a genome-wide approach, we profiled genomic aberrations in a small cohort of eight primary tumours, two relapses, and eight m
Externí odkaz:
https://doaj.org/article/8b49dfb082ed4a899ba3d82ba9ca5faa
Autor:
Julius M. Vahl, Marlene C. Wigand, Michael Denkinger, Dhayana Dallmeier, Chiara Steiger, Claudia Welke, Peter Kuhn, Christian Idel, Johannes Doescher, Adrian von Witzleben, Matthias Brand, Ralf Marienfeld, Peter Möller, Marie-Nicole Theodoraki, Jens Greve, Patrick J. Schuler, Cornelia Brunner, Thomas K. Hoffmann, Simon Laban
Publikováno v:
Cancers, Vol 13, Iss 4, p 832 (2021)
Background: The impact of demographic change on the age at diagnosis in German head and neck cancer (HNC) patients is unclear. Here we present an evaluation of aging trends in HNC at a tertiary referral center. Methods: Retrospective cohort study on
Externí odkaz:
https://doaj.org/article/988551ad3e4b4217b21b3cbbfb0700fb
Publikováno v:
Cells, Vol 9, Iss 9, p 2103 (2020)
Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of malignant tumours typically caused by alcohol and tobacco consumption, although an increasing number of HNSCC arise due to persistent infection with high-risk human papilloma
Externí odkaz:
https://doaj.org/article/ffce2798742f48d89f2b09b5c3be289a