Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Adrian Zietara"'
Autor:
Biyang Xu, Lashodya V. Dissanayake, Vladislav Levchenko, Adrian Zietara, Olha Kravtsova, Alexander Staruschenko
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110901- (2024)
Summary: The inwardly rectifying K+ channel Kir5.1 (Kcnj16) is essential in renal salt handling and blood pressure control. However, the underlying mechanisms are not fully understood. Here, we integrated transcriptomics and metabolomics to comprehen
Externí odkaz:
https://doaj.org/article/ccfc0fb341db4290ad4f5aefefb6b8cb
Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model
Autor:
Lashodya V. Dissanayake, Adrian Zietara, Vladislav Levchenko, Denisha R. Spires, Mariana Burgos Angulo, Ashraf El-Meanawy, Aron M. Geurts, Melinda R. Dwinell, Oleg Palygin, Alexander Staruschenko
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104887- (2022)
Summary: Uric acid (UA) is the final metabolite in purine catabolism in humans. Previous studies have shown that the dysregulation of UA homeostasis is detrimental to cardiovascular and kidney health. The Xdh gene encodes for the Xanthine Oxidoreduct
Externí odkaz:
https://doaj.org/article/e4f8acdf104a4bc3a8101254fea60d36
Autor:
Christine A. Klemens, Lashodya V. Dissanayake, Vladislav Levchenko, Adrian Zietara, Oleg Palygin, Alexander Staruschenko
Publikováno v:
Physiological Reports, Vol 10, Iss 15, Pp n/a-n/a (2022)
Abstract The AGTRAP‐PLOD1 locus is a conserved gene cluster containing several blood pressure regulatory genes, including CLCN6, MTHFR, NPPA, and NPPB. Previous work revealed that knockout of Clcn6 on the Dahl Salt‐Sensitive (SS) rat background (
Externí odkaz:
https://doaj.org/article/2154a351294a40a082dfca7c3f312567
Autor:
Daria V. Ilatovskaya, Vladislav Levchenko, Kristen Winsor, Gregory R. Blass, Denisha R. Spires, Elizaveta Sarsenova, Iuliia Polina, Adrian Zietara, Mark Paterson, Alison J. Kriegel, Alexander Staruschenko
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
Atrial natriuretic peptide (ANP), encoded by Nppa, is a vasodilatory hormone that promotes salt excretion. Genome-wide association studies identified Nppa as a causative factor of blood pressure development, and in humans, ANP levels were suggested a
Externí odkaz:
https://doaj.org/article/74c5ab87de0b4193aa9e8edabadba11b
Autor:
Adrian Zietara, Denisha R. Spires, Alexandria Juffre, Hannah M. Costello, G. Ryan Crislip, Lauren G. Douma, Vladislav Levchenko, Lashodya V. Dissanayake, Christine A. Klemens, Oksana Nikolaienko, Aron M. Geurts, Michelle L. Gumz, Alexander Staruschenko
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 79(11)
Background: Circadian rhythms play an essential role in physiological function. The molecular clock that underlies circadian physiological function consists of a core group of transcription factors, including the protein PER1 (Period1). Studies in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7209767218d6667cfb7765fd7380930
https://pubmed.ncbi.nlm.nih.gov/36093781
https://pubmed.ncbi.nlm.nih.gov/36093781
Publikováno v:
Physiology. 38
Circadian rhythm in the body is regulated through a central clock in the brain signaling through molecular clocks in the peripheral tissue. PER1, CRY, CLOCK, and BMAL1 are the 4 genes regulating the mechanism of the molecular clock. It has been estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9359af331ef0be7b03e8e915f0b48a79
https://doi.org/10.1152/physiol.2023.38.s1.5730360
https://doi.org/10.1152/physiol.2023.38.s1.5730360
Publikováno v:
Physiology. 38
The inverse effects that dietary sodium and potassium have on blood pressure have been known for some time. High sodium consumption is detrimental, while potassium supplementation is known to be beneficial, and the ratio of sodium/potassium consumpti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10438134de6ee722fc5a5d0562f56604
https://doi.org/10.1152/physiol.2023.38.s1.5731635
https://doi.org/10.1152/physiol.2023.38.s1.5731635
Autor:
Elena Isaeva, Ruslan Bohovyk, Mykhailo Fedoriuk, Alexey Shalygin, Christine A. Klemens, Adrian Zietara, Vladislav Levchenko, Jerod S. Denton, Alexander Staruschenko, Oleg Palygin
Publikováno v:
British Journal of Pharmacology. 179:2953-2968
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4daddfa5e0f3db68924396ccd7ff09
https://doi.org/10.1111/bph.15779
https://doi.org/10.1111/bph.15779
Autor:
Hannah M. Costello, Alexandria Juffre, Kit-Yan Cheng, Phillip Bratanatawira, G. Ryan Crislip, Adrian Zietara, Denisha R. Spires, Alexander Staruschenko, Lauren G. Douma, Michelle L. Gumz
Publikováno v:
Canadian journal of physiology and pharmacology.
Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium handling in the kidney's collecting duct. Dysregulation of the endothelin axis is associated with various diseases, including salt-sensitive hypertension and chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f64c6ac17854d0ebbfbe8a1897b52a
https://pubmed.ncbi.nlm.nih.gov/36450128
https://pubmed.ncbi.nlm.nih.gov/36450128
Autor:
Adrian Zietara, Lashodya Dissanayake, Vladislav Levchenko, Michelle L Gumz, Alexander Staruschenko
Publikováno v:
Hypertension. 79
Circadian rhythm is the 24-hr cycle experienced by most organisms which influences many physiological processes. Rhythms in physiological function are governed by a molecular circadian clock. Disruption of the circadian rhythm has been linked to dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45cadf0411dddd156436aa4fe92bdcc6
https://doi.org/10.1161/hyp.79.suppl_1.029
https://doi.org/10.1161/hyp.79.suppl_1.029