Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Adrian Wai-Hing Cheung"'
Autor:
Kshitij Chhabilbhai Thakkar, Bruce L. Banner, Shiming Li, Nicholas Marcopulos, Joseph A. Sergi, Jolly Bose, Weiya Yun, Catherine Zwingelstein, Adrian Wai-Hing Cheung, Kyungjin Kim, Steven Joseph Berthel, Bingbing Wang, Lucja Orzechowski, Andrée R. Olivier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7518-7522
High throughput screening of the Roche compound collection led to the identification of diaminopyrroloquinazoline series as a novel class of PTP1B inhibitors. Structural modification of diaminopyrroloquinazoline series resulted in pyrido[2,3-d]pyrimi
Autor:
Stanley Wertheimer, Lee Apostle Mcdermott, Stuart Hayden, Weiya Yun, Yingsi Chen, Anjula Pamidimukkala, Rebecca Taub, Kuo-Sen Huang, Toni Whittard, Liang Guo, Shiming Li, Jenny Tan, Fariborz Firooznia, Adrian Wai-Hing Cheung, David Robert Bolin, Nicholas Marcopulos, Yimin Qian, Karin Conde-Knape, Mushtaq Ahmad, Gwendolyn Ramsey, Cristina M. Rondinone, Jefferson Wright Tilley, Matthew Michael Hamilton
Publikováno v:
Journal of Medicinal Chemistry. 54:2433-2446
Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of diacylglycerol with acyl coenzyme A. DGAT-1 deficient mice demonstrate resistance to weight gain o
Autor:
Rachid Hamid, Roger David Norcross, Mary Lou Gubler, Ramakanth Sarabu, Fariborz Firooznia, Adrian Wai-Hing Cheung, John A. Brinkman, Nicholas Marcopulos, Lida Qi, Kevin Richard Guertin, Alexander Flohr, Jenny Tan, Gwendolyn Ramsey, Joseph Grimsby, Yang Wen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4140-4146
7-N-Acetamide-4-methoxy-2-aminobenzothiazole 4-fluorobenzamide (compound 1) was chosen as a drug-like and non-xanthine based starting point for the discovery of A(2B) receptor antagonists because of its slight selectivity against A(1) and A(2A) recep
Autor:
Hongmao Sun, Li Chen, Yao Wang, Chunlin Zhao, David C. Fry, Waleed Danho, Adrian Wai-Hing Cheung, David N. Greeley, Joseph Swistok, Xin-Jie Chu
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:2671-2677
Using nuclear magnetic resonance (NMR) spectroscopy, we have determined the solution structures for a series of potent agonists for the human melanocortin-4 receptor (hMC4R), based on the cyclic peptide MT-II [Ac-Nle-cyclo-(Asp-Lys) (Asp-His-(D)Phe-A
Autor:
Keith A. Yagaloff, Xin-Jie Chu, Lucia Franco, Mitch Yeon, Grazyna Kurylko, Lida Qi, Li Chen, Adrian Wai-Hing Cheung, Karen Rowan, Joseph Swistok, Waleed Danho
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1307-1311
A series of MT-II related cyclic peptides, based on potent but non-selective hMC4R agonist (Penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2)) was prepared in which His(6) residue was systematically substituted. Two of the most interesting peptides
Autor:
Adrian Wai-Hing, Cheung, Waleed, Danho, Joseph, Swistok, Lida, Qi, Grazyna, Kurylko, Lucia, Franco, Keith, Yagaloff, Li, Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2407-2410
A series of pentapeptides, based on Bu-His(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) and modified at the Arg(8) position, was prepared and pharmacologically characterized. Peptides containing either cyanoguanidine or acylguanidine, two substantially les
Publikováno v:
Tetrahedron Letters. 41:3303-3307
An unexpectedly low N-9/N-7 regioselectivity was obtained when Robins' reagent (2-N-acetyl-6-O-diphenylcarbamoylguanine) was coupled with a d -glucosamine derivative under trimethylsilyl trifluoromethanesulfonate activation. An unprecedented solvent
Autor:
Christine Lukacs, Effie Tozzo, Toni Whittard, Jia Kui Li, Cheryl Janson, Nicholas F. Brown, Nathan Robert Scott, Nancy-Ellen Haynes, Li C. Chen, Adrian Wai-Hing Cheung, Aruna Railkar
Publikováno v:
ACS medicinal chemistry letters. 3(9)
3-[4-((1S,2S,3R,5S,7S)-5-Hydroxyadamantan-2-ylcarbamoyl)benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester (4) was identified as a novel, druglike and selective quinolone pan JNK inhibitor. In this communication, som
Autor:
Rachid Hamid, Mary Lou Gubler, Yang Wen, Nicholas Marcopulos, Ramakanth Sarabu, Joseph Grimsby, Fariborz Firooznia, Jenny Tan, John A. Brinkman, Gwendolyn Ramsey, Adrian Wai-Hing Cheung
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(7)
The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-ethyl-acetamide derivative 2 was selected as the starting point for the design of novel selective A(2B) antagonists, due to its excellent potency, and good drug-like p
Publikováno v:
ChemInform. 31
An unexpectedly low N-9/N-7 regioselectivity was obtained when Robins' reagent (2-N-acetyl-6-O-diphenylcarbamoylguanine) was coupled with a d -glucosamine derivative under trimethylsilyl trifluoromethanesulfonate activation. An unprecedented solvent