Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Adrian V.S. Hill"'
Autor:
Xiangmin Lv, Jesse Martin, Heather Hoover, Bishnu Joshi, Margaret Wilkens, David A. Ullisch, Thomas Leibold, John S. Juchum, Sanket Revadkar, Barbara Kalinovska, Justin Keith, Adam Truby, Gui Liu, Elaine Sun, John Haserick, Jon DeGnore, Joseph Conolly, Adrian V.S. Hill, John Baldoni, Charlotte Kensil, Dan Levey, Alexandra J. Spencer, Gilbert Gorr, Mark Findeis, Antoine Tanne
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109006- (2024)
Summary: Many vaccines, including those using recombinant antigen subunits, rely on adjuvant(s) to enhance the efficacy of the host immune responses. Among the few adjuvants clinically approved, QS-21, a saponin-based immunomodulatory molecule isolat
Externí odkaz:
https://doaj.org/article/4ce190e0d41a4a90adc8bb0b7532bfc5
Autor:
Omar Ngoto, Mainga Hamaluba, Emmaloise Gathuri, Sam Provstgaard-Morys, Janet Musembi, Jeremy Aboagye, Lisa Stockdale, Racheal Roberts, Daniel Woods, Francis Ndungu, Kelvias Keter, Adrian V.S. Hill, Katie J. Ewer, Alison Lawrie, Samuel Sang, Philip Bejon, Irene Njau, Benedict Orindi, Melissa Kapulu, Edward Otieno, Mehreen S. Datoo, Duncan Bellamy, Charles Muiruri, Domtila Kimani
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Falciparum malaria remains a global health problem. Two vaccines, based on the circumsporozoite antigen, are available. RTS, S/AS01 was recommended for use in 2021 following the advice of the World Health Organisation (WHO) Strategic Advi
Externí odkaz:
https://doaj.org/article/ea0814482d4b411bacd4c871089026d6
Autor:
Meera Madhavan, Adam J. Ritchie, Jeremy Aboagye, Daniel Jenkin, Samuel Provstgaad-Morys, Iona Tarbet, Danielle Woods, Sophie Davies, Megan Baker, Abigail Platt, Amy Flaxman, Holly Smith, Sandra Belij-Rammerstorfer, Deidre Wilkins, Elizabeth J. Kelly, Tonya Villafana, Justin A. Green, Ian Poulton, Teresa Lambe, Adrian V.S. Hill, Katie J. Ewer, Alexander D. Douglas
Publikováno v:
EBioMedicine, Vol 85, Iss , Pp 104298- (2022)
Summary: Background: Intranasal vaccination may induce protective local and systemic immune responses against respiratory pathogens. A number of intranasal SARS-CoV-2 vaccine candidates have achieved protection in pre-clinical challenge models, inclu
Externí odkaz:
https://doaj.org/article/c0218306af9949dca4663ba77a6bcb87
Autor:
Mohamed Boudjelal, Faisal Almajed, Ahmed M. Salman, Naif K. Alharbi, Margaretta Colangelo, Julia M. Michelotti, Gene Olinger, Mariwan Baker, Adrian V.S. Hill, Ahmed Alaskar
Publikováno v:
International Journal of Infectious Diseases, Vol 105, Iss , Pp 448-451 (2021)
The 11th KAIMRC Annual Research Forum Themed “COVID-19 Vaccine: Global Challenges and Prospects Forum” discussed COVID19 Vaccines. The Forum was a vital event as it provided a hub for leading COVID-19 vaccine scientists, regulators, developers, a
Externí odkaz:
https://doaj.org/article/183d213dd6ca4dafb110275c83a44c2c
Autor:
Ane Ogbe, Matthew Pace, Mustapha Bittaye, Timothy Tipoe, Sandra Adele, Jasmini Alagaratnam, Parvinder K. Aley, M. Azim Ansari, Anna Bara, Samantha Broadhead, Anthony Brown, Helen Brown, Federica Cappuccini, Paola Cinardo, Wanwisa Dejnirattisai, Katie J. Ewer, Henry Fok, Pedro M. Folegatti, Jamie Fowler, Leila Godfrey, Anna L. Goodman, Bethany Jackson, Daniel Jenkin, Mathew Jones, Stephanie Longet, Rebecca A. Makinson, Natalie G. Marchevsky, Moncy Mathew, Andrea Mazzella, Yama F. Mujadidi, Lucia Parolini, Claire Petersen, Emma Plested, Katrina M. Pollock, Thurkka Rajeswaran, Maheshi N. Ramasamy, Sarah Rhead, Hannah Robinson, Nicola Robinson, Helen Sanders, Sonia Serrano, Tom Tipton, Anele Waters, Panagiota Zacharopoulou, Eleanor Barnes, Susanna Dunachie, Philip Goulder, Paul Klenerman, Gavin R. Screaton, Alan Winston, Adrian V.S. Hill, Sarah C. Gilbert, Miles Carroll, Andrew J. Pollard, Sarah Fidler, Julie Fox, Teresa Lambe, John Frater
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Duration of protection from SARS-CoV-2 infection in people living with HIV (PWH) following vaccination is unclear. In a substudy of the phase II/III the COV002 trial (NCT04400838), 54 HIV+ male participants on antiretroviral therapy (undetectable vir
Externí odkaz:
https://doaj.org/article/446dfee8ec4944f5951afc9fd4bc0066
Autor:
Hannah R. Sharpe, Nicholas M. Provine, Georgina S. Bowyer, Pedro Moreira Folegatti, Sandra Belij-Rammerstorfer, Amy Flaxman, Rebecca Makinson, Adrian V.S. Hill, Katie J. Ewer, Andrew J. Pollard, Paul Klenerman, Sarah Gilbert, Teresa Lambe
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Cytomegalovirus (CMV) is a globally ubiquitous pathogen with a seroprevalence of approximately 50% in the United Kingdom. CMV infection induces expansion of immunosenescent T cell and NK cell populations, with these cells demonstrating lower responsi
Externí odkaz:
https://doaj.org/article/e4a4682673c846b98452e03a01c6e769
Autor:
Carly M. Bliss, Andrea J. Parsons, Raffael Nachbagauer, Jennifer R. Hamilton, Federica Cappuccini, Marta Ulaszewska, Jason P. Webber, Aled Clayton, Adrian V.S. Hill, Lynda Coughlan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 108-125 (2020)
Adenoviral (Ad) vectors represent promising vaccine platforms for infectious disease. To overcome pre-existing immunity to commonly used human adenovirus serotype 5 (Ad5), vectors based on rare species or non-human Ads are being developed. However, t
Externí odkaz:
https://doaj.org/article/cd6a0c58b0e84b3aad7a70894ddac5d1
Autor:
Jonathan Powlson, Daniel Wright, Antra Zeltina, Mark Giza, Morten Nielsen, Tommy Rampling, Navin Venkatrakaman, Thomas A. Bowden, Adrian V.S. Hill, Katie J. Ewer
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2537-2545.e3 (2019)
Summary: Ebolavirus causes highly lethal hemorrhagic fever in humans. The envelope-displayed viral glycoprotein (GP) is the primary target of humoral immunity induced by natural exposure and vaccination. No T cell epitopes in the GP have been charact
Externí odkaz:
https://doaj.org/article/ebe16cc1a325464592d23c4905d28974
Autor:
André Scherag, Franziska Schöneweck, Miriam Kesselmeier, Stefan Taudien, Matthias Platzer, Marius Felder, Christoph Sponholz, Anna Rautanen, Adrian V.S. Hill, Charles J. Hinds, Hamid Hossain, Norbert Suttorp, Oliver Kurzai, Hortense Slevogt, Evangelos J. Giamarellos-Bourboulis, Apostolos Armaganidis, Evelyn Trips, Markus Scholz, Frank M. Brunkhorst
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 239-246 (2016)
Sepsis is the dysregulated host response to an infection which leads to life-threatening organ dysfunction that varies by host genomic factors. We conducted a genome-wide association study (GWAS) in 740 adult septic patients and focused on 28 day mor
Externí odkaz:
https://doaj.org/article/29c69f886ddd4592829bd7918a916263
Autor:
Daniel O’Connor, Eileen Png, Chiea Chuen Khor, Matthew D. Snape, Adrian V.S. Hill, Fiona van der Klis, Clive Hoggart, Michael Levin, Martin L. Hibberd, Andrew J. Pollard
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3241-3253.e4 (2019)
Summary: Vaccines have revolutionized public health, preventing millions of deaths each year, particularly in childhood. Yet, there is considerable variability in the magnitude and persistence of vaccine-induced immunity. Maintenance of specific anti
Externí odkaz:
https://doaj.org/article/2327a2cf1a4c46d69e8b9fc1fdf6b884