Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Adrian Thrasher"'
Autor:
Stuart Ellison, Karen Buckland, Yuko Learmonth, Victoria Day, Spandan Kalra, Lauren Howe, Francisco José Roman-Rodriguez, Jose Bonafont, Laura Booth, Rebecca Holley, Jon Smythe, Simon Jones, Adrian Thrasher, Claire Booth, Brian W. Bigger
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101271- (2024)
Hematopoietic stem cell gene therapy (HSCGT) is a promising therapeutic strategy for the treatment of neurodegenerative, metabolic disorders. The approach involves the ex vivo introduction of a missing gene into patients’ own stem cells via lentivi
Externí odkaz:
https://doaj.org/article/c6d56cc1cb214a2393e79a6e7acc9046
Autor:
Marina Cavazzana, Adrian Thrasher
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/01c1d0bb3ef74370b897b9051f64df9b
Autor:
Sara Deola, Bella S. Guerrouahen, Heba Sidahmed, Anjud Al-Mohannadi, Muhammad Elnaggar, Ramaz Elsadig, Essam M. Abdelalim, Goran Petrovski, Massimo Gadina, Adrian Thrasher, Winfried S. Wels, Stephen P. Hunger, Ena Wang, Francesco M. Marincola, ATH Consortium, Cristina Maccalli, Chiara Cugno
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract New technologies and therapies designed to facilitate development of personalized treatments are rapidly emerging in the field of biomedicine. Strikingly, the goal of personalized medicine refined the concept of therapy by developing cell-ba
Externí odkaz:
https://doaj.org/article/224e584b3e3a4cd5860bba423421ef7d
Autor:
Michelle Escobedo-Cousin, Nicola Jackson, Raquel Laza-Briviesca, Linda Ariza-McNaughton, Martha Luevano, Sophie Derniame, Sergio Querol, Michael Blundell, Adrian Thrasher, Bernat Soria, Nichola Cooper, Dominique Bonnet, Alejandro Madrigal, Aurore Saudemont
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0138623 (2015)
Cord blood (CB) is increasingly used as a source of hematopoietic stem cells (HSC) for transplantation. Low incidence and severity of graft-versus-host disease (GvHD) and a robust graft-versus-leukemia (GvL) effect are observed following CB transplan
Externí odkaz:
https://doaj.org/article/61338b5b55e84bd6ac0a9b65853c1cf0
Autor:
Martha Luevano, Anna Domogala, Michael Blundell, Nicola Jackson, Isabela Pedroza-Pacheco, Sophie Derniame, Michelle Escobedo-Cousin, Sergio Querol, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87086 (2014)
Adoptive natural killer (NK) cell therapy relies on the acquisition of large numbers of NK cells that are cytotoxic but not exhausted. NK cell differentiation from hematopoietic stem cells (HSC) has become an alluring option for NK cell therapy, with
Externí odkaz:
https://doaj.org/article/1901303d936645e3a52cf1c962129a8a
Autor:
Anne-Christine Field, Conrad Vink, Richard Gabriel, Roua Al-Subki, Manfred Schmidt, Nicholas Goulden, Hans Stauss, Adrian Thrasher, Emma Morris, Waseem Qasim
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68201 (2013)
Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems. Whilst important proof-of-principle data has bee
Externí odkaz:
https://doaj.org/article/3ac31bb6c4464dc593cbe62cdfbb9aea
Autor:
Hong Zhan, Kimberly Gilmour, Lucas Chan, Farzin Farzaneh, Anne Marie McNicol, Jin-Hua Xu, Stuart Adams, Boris Fehse, Paul Veys, Adrian Thrasher, Hubert Gaspar, Waseem Qasim
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77106 (2013)
UNLABELLED:Suicide gene modified donor T cells can improve immune reconstitution after allogeneic haematopoietic stem cell transplantation (SCT), but can be eliminated in the event of graft versus host disease (GVHD) through the administration of pro
Externí odkaz:
https://doaj.org/article/be86fad29a354a36ad7d69f4dfbca884
Autor:
Ulrich Abel, Annette Deichmann, Cynthia Bartholomae, Kerstin Schwarzwaelder, Hanno Glimm, Steven Howe, Adrian Thrasher, Alexandrine Garrigue, Salima Hacein-Bey-Abina, Marina Cavazzana-Calvo, Alain Fischer, Dirk Jaeger, Christof von Kalle, Manfred Schmidt
Publikováno v:
PLoS ONE, Vol 2, Iss 6, p e570 (2007)
Features such as mutations or structural characteristics can be non-randomly or non-uniformly distributed within a genome. So far, computer simulations were required for statistical inferences on the distribution of sequence motifs. Here, we show tha
Externí odkaz:
https://doaj.org/article/784f693a8b48436bb2fa60a421ba9ed1
Autor:
Kenneth Cornetta, Jing Yao, Kimberley House, Lisa Duffy, Prasad S. Adusumilli, Rachel Beyer, Claire Booth, Malcolm Brenner, Kevin Curran, Bambi Grilley, Helen Heslop, Christian S. Hinrichs, Rosandra N. Kaplan, Hans-Peter Kiem, James Kochenderfer, Donald B. Kohn, Sham Mailankody, Scott M. Norberg, Roisin E. O'Cearbhaill, Jennifer Pappas, Jae Park, Carlos Ramos, Antonio Ribas, Isabelle Rivière, Steven A. Rosenberg, Craig Sauter, Nirali N. Shah, Susan F. Slovin, Adrian Thrasher, David A. Williams, Tsai-Yu Lin
Publikováno v:
Molecular Therapy. 31:801-809
The clinical impact of any therapy requires the product be safe and effective. Gammaretroviral vectors pose several unique risks, including inadvertent exposure to replication competent retrovirus (RCR) that can arise during vector manufacture. The U
Engineering HEK293T cell lines to express nuclease for DNA clearance in lentiviral vector production
Autor:
Darren Nesbeth, Waseem Qasim, Adrian Thrasher, Chris Mason, John Ward, Eli Keshavarz-Moore, Aminat Omotosho, Desmond Schofield, Claudia Rivera-Trujillo, Sadfer Ali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06db6fe26ddfd6de01b5a84d00b709d0
https://doi.org/10.1021/scimeetings.1c01227
https://doi.org/10.1021/scimeetings.1c01227