Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Adrian T. Ting"'
Autor:
Nicholas Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin III, Julian K. Horwitz, Jesse D. Gelles, Jerry Edward Chipuk, Michelle A. Kelliher, Vasile I. Pavlov, Yansui Li, Dirk Homann, Peter S. Heeger, Adrian T. Ting
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
TNF ligation of TNF receptor 1 (TNFR1) promotes either inflammation and cell survival by (a) inhibiting RIPK1’s death-signaling function and activating NF-κB or (b) causing RIPK1 to associate with the death-inducing signaling complex to initiate a
Externí odkaz:
https://doaj.org/article/1cef15809b5044ec872dc4819293a566
Autor:
Yolanda Garcia-Carmona, Adrian T. Ting, Lin Radigan, Sai Krishna Athuluri Divakar, Jose Chavez, Eric Meffre, Andrea Cerutti, Charlotte Cunningham-Rundles
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/86652938ac8642a59c01677dab04cdb8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
The clinical success of biologics that inhibit TNF (Tumor Necrosis Factor) in inflammatory bowel diseases (IBD), psoriasis and rheumatoid arthritis (RA) has clearly established a pathogenic role for this cytokine in these inflammatory disorders. TNF
Externí odkaz:
https://doaj.org/article/4e33f1a75b6b4d7f964ca383f606545e
Autor:
Linda R. Klei, Dong Hu, Robert Panek, Danielle N. Alfano, Rachel E. Bridwell, Kelly M. Bailey, Katherine I. Oravecz-Wilson, Vincent J. Concel, Emily M. Hess, Matthew Van Beek, Phillip C. Delekta, Shufang Gu, Simon C. Watkins, Adrian T. Ting, Peter J. Gough, Kevin P. Foley, John Bertin, Linda M. McAllister-Lucas, Peter C. Lucas
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 221-232 (2016)
Microvascular endothelial cells maintain a tight barrier to prevent passage of plasma and circulating immune cells into the extravascular tissue compartment, yet endothelial cells respond rapidly to vasoactive substances, including thrombin, allowing
Externí odkaz:
https://doaj.org/article/cce9abcff6c34a83b79de4a656582ede
Autor:
Diana Legarda, Scott J. Justus, Rosalind L. Ang, Nimisha Rikhi, Wenjing Li, Thomas M. Moran, Jianke Zhang, Emiko Mizoguchi, Matija Zelic, Michelle A. Kelliher, J. Magarian Blander, Adrian T. Ting
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2449-2461 (2016)
Tumor necrosis factor (TNF) induces necroptosis, a RIPK3/MLKL-dependent form of inflammatory cell death. In response to infection by Gram-negative bacteria, multiple receptors on macrophages, including TLR4, TNF, and type I IFN receptors, are concurr
Externí odkaz:
https://doaj.org/article/8c0a3848a6e94f09b0ce11ed75eae8fa
Autor:
Yolanda Garcia-Carmona, Adrian T. Ting, Lin Radigan, Sai Krishna Athuluri Divakar, Jose Chavez, Eric Meffre, Andrea Cerutti, Charlotte Cunningham-Rundles
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
TACI signals activate B cell proliferation, isotype switch and antibody production in both normal immunity and autoimmune states. In contrast to murine TACI, the human TACI gene undergoes alternative splicing to produce short and long isoforms (TACI-
Externí odkaz:
https://doaj.org/article/923d496975e9445f9bb0681751cdeacf
Autor:
Shaomeng Wang, Adrian T. Ting, Shi-Yong Sun, Chunhai Hao, Anita Bellail, Meilan Liu, Han Yi, Jinhui Liao, Rebecca Miller, Su Qiu, Yuefeng Peng, Longchuan Bai, Haiying Sun, Donna McEachern, Jianfeng Lu
Smac mimetics are being developed as a new class of anticancer therapies. Because the single-agent activity of Smac mimetics is very limited, rational combinations represent a viable strategy for their clinical development. The combination of Smac mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f6f3a0b97759a359ae8d81d7ed1f7d
https://doi.org/10.1158/1535-7163.c.6535461
https://doi.org/10.1158/1535-7163.c.6535461
Autor:
Shaomeng Wang, Adrian T. Ting, Shi-Yong Sun, Chunhai Hao, Anita Bellail, Meilan Liu, Han Yi, Jinhui Liao, Rebecca Miller, Su Qiu, Yuefeng Peng, Longchuan Bai, Haiying Sun, Donna McEachern, Jianfeng Lu
Supplementary Figures 1-15 from Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454a028504c54354b4fdbc22b7aaaa39
https://doi.org/10.1158/1535-7163.22496991.v1
https://doi.org/10.1158/1535-7163.22496991.v1
Autor:
Lili Chen, Zhengxiang He, Bernardo S. Reis, Jesse D. Gelles, Jerry Edward Chipuk, Adrian T. Ting, Julie A. Spicer, Joseph A. Trapani, Glaucia C. Furtado, Sergio A. Lira
Publikováno v:
Cellular & Molecular Immunology. 19:777-790
The food colorant Red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin (IL)-23. This immune response is mediated by CD4+ T cells, but mechanistic insights into how these CD4+ T cells trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8029d722cc7475501c60c4fb857897
https://doi.org/10.1038/s41423-022-00864-3
https://doi.org/10.1038/s41423-022-00864-3
Autor:
Rosalind L. Ang, Mark Chan, Diana Legarda, John P. Sundberg, Shao-Cong Sun, Virginia L. Gillespie, Nicholas Chun, Peter S. Heeger, Huabao Xiong, Sergio A. Lira, Adrian T. Ting
Publikováno v:
Proc Natl Acad Sci U S A
SHARPIN, together with RNF31/HOIP and RBCK1/HOIL1, form the linear ubiquitin chain assembly complex (LUBAC) E3 ligase that catalyzes M1-linked polyubiquitination. Mutations in RNF31/HOIP and RBCK/HOIL1 in humans and Sharpin in mice lead to autoinflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a07b6fa7af5c8390947cb9add5d26a9
https://doi.org/10.1073/pnas.2001602118
https://doi.org/10.1073/pnas.2001602118