Safety of Rifampicin at High Dose for Difficult-to-Treat Tuberculosis: Protocol for RIAlta Phase 2b/c Trial

Autor: Juan Espinosa-Pereiro, Samiksha Ghimire, Marieke G. G. Sturkenboom, Jan-Willem C. Alffenaar, Margarida Tavares, Sarita Aguirre, Arturo Battaglia, Gladys Molinas, Teresa Tórtola, Onno W. Akkerman, Adrian Sanchez-Montalva, Cecile Magis-Escurra

Publikováno v: Pharmaceutics, Vol 15, Iss 1, p 9 (2022)

Previous clinical trials for drug-susceptible tuberculosis (DS-TB) have shown that first-line treatment with doses of rifampicin up to 40 mg/kg are safe and increase the early treatment response for young adults with pulmonary tuberculosis. This may

Externí odkaz: https://doaj.org/article/d0194403c7eb40c1a85ede0bce7d7239

ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores

Autor: Natalia Lima Rangel, Daniel Taiar Marinho Oliveira Ferrara, Natalia da Cunha Severino Sampaio, Máderson Alvares de Souza Cabral, Angelinda Rezende Bhering, Emanuele Marianne Souza Kroger, Rafael Lima Rodrigues de Carvalho, Lucas de Deus Sousa, Ana Luiza Bahia Alves Scotton, Roger Mendes de Abreu, Fernando Graca Aranha, Meire Pereira de Figueiredo, Guilherme Fagundes Nascimento, Luanna da Silva Monteiro, Frederico Bartolazzi, Juliana Machado Rugolo, Maria Aparecida Camargos Bicalho, Luciana Siuves Ferreira Couto, Rochele Mosmann Menezes, Luciane Kopittke, Natalia Trifiletti Crespo, Daniela Ponce, Eric Boersma, Patricia Klarmann Ziegelmann, Amanda de Oliveira Maurilio, Carisi Anne Polanczyk, Raquel Lutkmeier, Christiane Correa Rodrigues cimini, Bruno Mateus de Castro, Giovanna Grunewald Vietta, José Miguel Chatkin, Neimy Ramos de Oliveira, Thaís Lorenna Souza Sales, Lilian Santos Pinheiro, Angelica Aparecida Coelho Madureira, Gisele Alsina Nader Bastos, Elayne Crestani Pereira, Fernanda Barbosa Lucas, Karen Cristina Jung Rech Pontes, Maria Angelica Pires Ferreira, Liliane Souto Pacheco, Raphael Castro Martins, Andre Soares de Moura Costa, Helena Duani, Roberta Xavier Campos, Andre Pinheiro Weber, Matheus Carvalho Alves Nogueira, Rodolfo Lucas Silva Mourato, Silvia Ferreira Araujo, Renan Goulart Finger, Adrian Sanchez Montalva, Reginaldo Aparecido Valacio, Daniel Vitorio Silveira, Magda Carvalho Pires, Maíra Viana Rego Souza e Silva, Marcela Goncalves Trindade Tofani, Milena Soriano Marcolino, Saionara Cristina Francisco, Karen Brasil Ruschel, Tatiani Oliveira Fereguetti, L. E. F. Ramos, Israel Júnior Borges do Nascimento, Thaiza Simonia Marinho Albino de Araujo, Silvana Mangeon Mereilles Guimaraes, Rafaela dos Santos Charao de Almeida, Marcus Vinicius de Melo Andrade, Joanna d'Arc Lyra Batista, Andressa Barreto Glaeser, Veridiana Baldon dos Santos Santos, Henrique Cerqueira Guimaraes, Vitor Augusto Lima do Vale, Joice Coutinho de Alvarenga, Heloisa Reniers Vianna, Ricardo Bertoglio Cardoso, Petrônio José de Lima Martelli, Glicia Cristina de Castro Madeira, Fernando Anschau, Tatiana Kurtz, Milton Henriques Guimaraes Junior, Maria Clara Pontello Barbosa Lima, Mariana Frizzo de Godoy, Luana Martins Oliveira, Kauane Aline Maciel dos Santos, Gabriela Petry Crestani, Luisa Elem Almeida Santos, Fernando Antônio Botoni, Carla Thais Candida Alves da Silva, Felipe Barbosa Vallt, Rufino de Freitas Silva, Cintia Alcantara de Carvalho, Barbara Lopes Farace, Diego Henrique de Vasconcelos, Luis Cesar Souto de Moura, Alexandre Vargas Schwarbold, Karina Paula Medeiros Prado Martins, Julia Drumond Parreiras de Morais, Luís César de Castro, Pedro Ledic Assaf, Maiara Anschau Floriani, Roberta Pozza, Maira Dias Souza, Isabela Moraes Gomes, Susany Anastacia Pereira, Thainara Conceicao de Oliveira, Yuri Carlotto Ramires, Carolina Marques Ramos, Israel Molina Romero, Caroline Danubia Gomes, Rafael Guimarães Tavares da Silva, Marilia Mastrocolla de Almeida Cardoso, Berta Raventós, Leonardo Seixas de Oliveira, Virginia Mara Reis Gomes, Talita Fischer Oliveira, Thulio Henrique Oliveira Diniz, Julia Di Sabatino Santos Guimaraes, Ana Paula Beck da Silva Etges, Helena Carolina Noal, Marcelo Carneiro, Edilson Cezar

ObjectiveTo develop and validate a rapid scoring system at hospital admission for predicting in-hospital mortality in patients hospitalized with coronavirus disease 19 (COVID-19), and to compare this score with other existing ones.DesignCohort studyS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00205d9e12af4c693d4f165f1c43a72d
https://doi.org/10.1101/2021.02.01.21250306

National advisory services for multidrug-resistant tuberculosis (MDRTB) in Europe

Autor: Jean-Pierre Zellweger, Mateja Janković, Reinout van Crevel, Dmytro Butov, Alexander Dyatlov, Ohanna Kirakosyan, Maria Korzeniewska, Stela Kulcitkaia, Onno W. Akkerman, Kataerina Manika, Graham H. Bothamley, Nils Wetzstein, Alena Skrahina, Cecile Magis-Escurra, Regina Holland, Katarzyna Kruczak, Fusun Oner Eyuboglu, Zorica Nanovoc, Christian Wejse, Jean-Philippe Lanoix, Holger Flick, Elena Chiappini, Otto D. Schoch, Lothar Wiese, José María García García, Nicolas Veziris, Christoph Lange, Trude Marget Arnesen, Hasan Hafizi, Troels Lillebaek, Linda Barkana, Tuula Vasankari, Anna Starshinova, Joan Pau Millet, Miguel Arias, Dragica Pesut, Marleen Bakker, Emmanuel André, Liga Kuksa, Olha Konstantynovska, Dimitros Papaventis, Johan Normark, Joseph Keane, Rita Macedo, Andrea Calcagno, Einar Heldel, Adrian Sanchez Montalva, Ivan Solovic

Publikováno v: European Respiratory Journal, 54. EUROPEAN RESPIRATORY SOC JOURNALS LTD

Introduction: Treatment of MDRTB is complex: regimens require microbiological data; adverse events are frequent; availability of drugs and authorization for new drugs varies. The aim of this study was to scope the available national resources. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2133ecc7801d153287f1f450e3580a1
https://doi.org/10.1183/13993003.congress-2019.PA5285

Safety of Rifampicin at High Dose for Difficult-to-Treat Tuberculosis: Protocol for RIAlta Phase 2b/c Trial.

Autor: Espinosa-Pereiro, Juan^1,2 (AUTHOR), Ghimire, Samiksha³ (AUTHOR), Sturkenboom, Marieke G. G.³ (AUTHOR), Alffenaar, Jan-Willem C.^3,4,5,6 (AUTHOR), Tavares, Margarida⁷ (AUTHOR), Aguirre, Sarita⁸ (AUTHOR), Battaglia, Arturo⁹ (AUTHOR), Molinas, Gladys⁹ (AUTHOR), Tórtola, Teresa¹⁰ (AUTHOR), Akkerman, Onno W.^11,12 (AUTHOR), Sanchez-Montalva, Adrian^1,2,13 (AUTHOR) adrian.sanchez.montalva@vallhebron.cat, Magis-Escurra, Cecile¹⁴ (AUTHOR)

Publikováno v: Pharmaceutics. Jan2023, Vol. 15 Issue 1, p9. 13p.

New Findings from Bellvitge University Hospital in the Area of Meningitis Described (Mortality and Sequelae of Tuberculous Meningitis In a High-resource Setting: a Cohort Study, 1990-2017).

Publikováno v: TB & Outbreaks Week; 11/15/2024, p1557-1557, 1p