Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Adrian S. Culf"'
Autor:
Miroslava Cuperlovic-Culf, Mohamed Touaibia, Patrick-Denis St-Coeur, Julie Poitras, Pier Morin, Adrian S. Culf
Publikováno v:
Metabolites, Vol 4, Iss 3, Pp 807-830 (2014)
Inhibition of protein deacetylation enzymes, alone or in combination with standard chemotherapies, is an exciting addition to cancer therapy. We have investigated the effect of deacetylase inhibition on the metabolism of glioblastoma cells. 1H NMR me
Externí odkaz:
https://doaj.org/article/6a3c19e4a5164151b7ce9b4046efc52a
Autor:
Rodney J. Ouellette, Adrian S. Culf
Publikováno v:
Molecules, Vol 15, Iss 8, Pp 5282-5335 (2010)
Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences. Of particular interest are their applications
Externí odkaz:
https://doaj.org/article/cd6825126d6946c9b46d5276206a61b1
Autor:
Martin G. Léger, David Barnett, Daniel Leger, Rodney J. Ouellette, Adrian S. Culf, Mohamed Touaibia
Publikováno v:
Letters in Organic Chemistry. 13:566-571
Autor:
Adrian S. Culf
Publikováno v:
Biopolymers. 110(6)
A review of molecular tools and sensors assembled on N-substituted glycine, or α-peptoid, oligomers between 2013 and November 2018 with the following sections: (a) Peptoids as crystal growth modifiers, (b) Peptoids as catalysts, (c) Ion and molecule
Publikováno v:
Organic Letters. 16:2780-2783
A convenient and efficient methodology for the head-to-tail macrocyclization of small 3-mer, 4-mer, and 5-mer α-peptoid acids (9-, 12-, and 15-atom N-substituted glycine oligomers) is described. The cyclic trimer has a ccc amide sequence in the crys
Autor:
Vett K. Lloyd, Mohamed Touaibia, Adrian S. Culf, Natalie Lefort, Amy N. Brown, Rodney J. Ouellette, Miroslava Cuperlovic-Culf
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 93:77-85
Metabolomics analysis was used to determine the effect of two well known, non-proprietary metabolic modulators, dichloroacetate and allopurinol on breast cancer cell lines. Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor and allopurinol, a
Autor:
Sherri A. McFarland, Anirban Ghosh, Adrian S. Culf, Rodney J. Ouellette, Susan Monro, Miroslava Cuperlovic-Culf, David Barnett, Huimin Yin
Small-molecule fluorescent reporters of disease states are highly sought after, yet they remain elusive. Anthranilic acids are extremely sensitive environmental probes, and hold promise as general but selective agents for cancer-cell detection if the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee508911f0fb55ae188d003d503c73f1
https://nrc-publications.canada.ca/eng/view/object/?id=a85ad795-9943-4b92-8577-5575f160c84b
https://nrc-publications.canada.ca/eng/view/object/?id=a85ad795-9943-4b92-8577-5575f160c84b
Publikováno v:
Current Metabolomics. 1:41-57
High throughput analysis of metabolites combined with systems biology is opening new opportunities in medical research and clinical applications. Investigation of metabolic phenotype and metabolic requirements of a disease opens new avenues for treat
Publikováno v:
Future Oncology. 8:1315-1330
The metabolism of tumors is remarkably different from the metabolism of corresponding normal cells and tissues. Metabolic alterations are initiated by oncogenes and are required for malignant transformation, allowing cancer cells to resist some cell
Publikováno v:
Journal of Biological Chemistry. 287:20164-20175
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by unpredictable clinical behaviors that suggest distinct molecular subtypes. With the tumor metabolic phenotype being one of the hallmarks of cancer, we have se