Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Adrian Rump"'
Autor:
Michael Grimm, Adrian Rump, Marie-Luise Kromrey, Felix Morof, Camille Dumont, Vincent Jannin, Mladen Vassilev Tzvetkov, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2576 (2023)
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness
Externí odkaz:
https://doaj.org/article/b17e1b020db1404c97cfa1b56c1ea7ce
Autor:
Theodora Tzakri, Lara Rehenbrock, Stefan Senekowitsch, Adrian Rump, Philipp Schick, Julius Krause, Marie-Luise Kromrey, Michael Grimm, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2584 (2023)
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary trace
Externí odkaz:
https://doaj.org/article/43bcb0d5ba9749b5b2b8d3aaef41c1ea
Autor:
Laura Müller, Christoph Rosenbaum, Adrian Rump, Michael Grimm, Friederike Klammt, Annabel Kleinwort, Alexandra Busemann, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1740 (2023)
The absorption of drugs with narrow absorption windows in the upper small intestine can be improved with a mucoadhesive drug delivery system such as enteric films. To predict the mucoadhesive behaviour in vivo, suitable in vitro or ex vivo methods ca
Externí odkaz:
https://doaj.org/article/953642b8ece042f8843b5050ccc36363
Autor:
Hannes Gierke, Susan Mouchantat, Sabine Berg, Michael Grimm, Stefan Hadlich, Marie-Luise Kromrey, Thomas Nolte, Teresa Pfrommer, Vincent Rönnpagel, Adrian Rump, Kerstin Schaefer, Ann-Cathrin Willmann, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 887 (2023)
Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral admi
Externí odkaz:
https://doaj.org/article/f69929ad31144b1fb0122747bb65fa12
Autor:
Michael Grimm, Adrian Rump, Lisa Meilicke, Maximilian Feldmüller, Rebecca Keßler, Eberhard Scheuch, Mladen Vassilev Tzvetkov, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 328 (2023)
Gastric water emptying as a critical parameter for oral drug absorption can be investigated by several imaging techniques or by the interpretation of pharmacokinetics of appropriate substances. Recently introduced salivary caffeine kinetics is a valu
Externí odkaz:
https://doaj.org/article/43655eb87d1345308934f24ac0b52938
Autor:
Adrian Rump, Marie-Luise Kromrey, Eberhard Scheuch, Vincent Jannin, Lara Rehenbrock, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 1999 (2022)
Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the first place
Externí odkaz:
https://doaj.org/article/6a9c42fae777422f8cc17f5817e3fe94
Autor:
Adrian Rump, Franziska N. Weiss, Louisa Schulz, Marie-Luise Kromrey, Eberhard Scheuch, Mladen V. Tzvetkov, Tyler White, Shane Durkee, Kevin W. Judge, Vincent Jannin, Aouatef Bellamine, Werner Weitschies, Michael Grimm
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2002 (2021)
Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules (size 3) and
Externí odkaz:
https://doaj.org/article/23bb7f9e40bd4f1ca17bc2316b3eb792
Autor:
Christoph Rosenbaum, Michael Grimm, Julius Krause, Adrian Rump, Rebecca Kessler, Norbert Hosten, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 828 (2021)
There are no methods for specific local application of active substances to the mucosa of the esophagus to treat eosinophilic esophagitis or other esophageal diseases. This publication describes the principal in vivo functionality and acceptance of a
Externí odkaz:
https://doaj.org/article/ee4e6f7d95d340a6acb9414e52aaf99b
Autor:
Adrian Rump, Carolin Tetyczka, Eva Littringer, Marie-Luise Kromrey, Robin Bülow, Eva Roblegg, Werner Weitschies, Michael Grimm
Publikováno v:
Molecular Pharmaceutics. 20:1624-1630
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::811709055f120757b68565257bd14c84
https://doi.org/10.1021/acs.molpharmaceut.2c00835
https://doi.org/10.1021/acs.molpharmaceut.2c00835
Autor:
Weitschies, Laura Müller, Christoph Rosenbaum, Adrian Rump, Michael Grimm, Friederike Klammt, Annabel Kleinwort, Alexandra Busemann, Werner
Publikováno v:
Pharmaceutics; Volume 15; Issue 6; Pages: 1740
The absorption of drugs with narrow absorption windows in the upper small intestine can be improved with a mucoadhesive drug delivery system such as enteric films. To predict the mucoadhesive behaviour in vivo, suitable in vitro or ex vivo methods ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::6d4fbe325e12e07abb600c404431ce30