Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Adrian R. West"'
Autor:
Matthew D. Martens, Nivedita Seshadri, Lucas Nguyen, Donald Chapman, Elizabeth S. Henson, Bo Xiang, Landon Falk, Arielys Mendoza, Sunil Rattan, Jared T. Field, Philip Kawalec, Spencer B. Gibson, Richard Keijzer, Ayesha Saleem, Grant M. Hatch, Christine A. Doucette, Jason M. Karch, Vernon W. Dolinsky, Ian M. Dixon, Adrian R. West, Christof Rampitsch, Joseph W. Gordon
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-16 (2021)
Abstract Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and i
Externí odkaz:
https://doaj.org/article/e1343dcb2c5b484c91d04a2bde3e5a8e
Autor:
Jeffery O Osagie, Sanjana S Syeda, Emily Turner-Brannen, Michelle Guimond, Lumiere Parrenas, Ahsen Haroon, Philip Imasuen, Adrian R West
Publikováno v:
C109. EVEN BETTER THAN THE REAL THING: ADVANCED MODELS OF LUNG DISEASE.
The contractile function of airway smooth muscle (ASM) is inextricably linked to its mechanical properties and interaction with the surrounding mechanical environment. As tissue engineering approaches become more commonplace for studying lung biology
Autor:
Wai Hei Tse, Sean Higgins, Daywin Patel, Malcolm Xing, Adrian R. West, Hagar I. Labouta, Richard Keijzer
Publikováno v:
Biomaterials science. 10(18)
Nanoparticles administered into the maternal circulation and across the placenta are a potential clinical therapy to treat congenital diseases. The mechanism by which nanoparticles can safely cross the placenta for targeted drug delivery to the fetus
Autor:
Vernon W. Dolinsky, Simone C. da Silva Rosa, Saeid Ghavami, Christof Rampitsch, Lucas Nguyen, James A. Thliveris, Matthew D. Martens, Donald Chapman, Joseph W. Gordon, Adrian R. West, Stephanie M. Kereliuk, Yan Hai, Jared T. Field, William Diehl-Jones, Michel Aliani
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Lipotoxicity is a form of cellular stress caused by the accumulation of lipids resulting in mitochondrial dysfunction and insulin resistance in muscle. Previously, we demonstrated that the mitophagy receptor BNIP3L/Nix is responsive to lipotoxicity a
Autor:
Patience O. Obi, Samira Seif, Benjamin Bydak, Taiana M. Pierdoná, Emily Turner-Brannen, Adrian R. West, Hagar I. Labouta, Joseph W. Gordon, Ayesha Saleem
Extracellular vesicles (EVs) are small lipid membrane-bound structures that are secreted by all cells, and play a central role in cellular communication. EVs are released from skeletal muscle during exercise, but the effects of contractile activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a555ebfa7d9cf74c1a49675608170080
https://doi.org/10.1101/2022.02.25.481852
https://doi.org/10.1101/2022.02.25.481852
Autor:
Neilloy Roy, Alexander Schultz, Emily Turner-Brannen, Jignesh Vaghasiya, Amir Ravandi, Adrian R. West, Christopher D. Pascoe, Andrew J. Halayko
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 321(4)
Oxidative stress is a hallmark of numerous airway diseases, contributing to extensive cell and tissue damage. Cell membranes and the airway mucosal lining are rich in phospholipids that are particularly susceptible to oxidative attack, producing bioa
Autor:
Vernon W. Dolinsky, Richard Keijzer, Joseph W. Gordon, Nivedita Seshadri, Lucas Nguyen, Adrian R. West, Christine A. Doucette, Landon Falk, Jason Karch, Elizabeth S. Hensen, Ian M.C. Dixon, Sunil G. Rattan, Donald Chapman, Grant M. Hatch, Christof Rampitsch, Matthew D. Martens, Spencer B. Gibson, Bo Xiang, Arielys Mendoza, Ayesha D Saleem
Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and initiating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::100a0dfba49fb6924daa57b01e115033
https://doi.org/10.1101/2020.10.09.333666
https://doi.org/10.1101/2020.10.09.333666
Autor:
Jared T. Field, Matthew D. Martens, Nivedita Seshadri, Tammy L. Ivanco, Christine A. Doucette, Joseph W. Gordon, Adrian R. West, Chelsea Day
Publikováno v:
Circulation Research. 127
Systemic hypoxia resulting from preterm birth, altered lung development, and cyanotic congenital heart disease is known to impede the regulatory and developmental pathways in the neonatal heart. While the molecular mechanisms are still unknown, hypox
Autor:
Matthew D. Martens, Donald Chapman, Simone C. da Silva Rosa, Michel Aliani, Lucas Nguyen, James A. Thliveris, Jared T. Field, Adrian R. West, Stephanie M. Kereliuk, William Diehl-Jones, Christof Rampitsch, Joseph W. Gordon, Yan Hai, Saeid Ghavami, Vernon W. Dolinsky
Lipotoxicity is a form of cellular stress caused by the accumulation of lipids resulting in mitochondrial dysfunction and insulin resistance in muscle. Previously, we demonstrated that the mitophagy receptor Nix is responsive to lipotoxicity and accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb630baec0c1a7c94573f8a5dc482f9
https://doi.org/10.1101/825828
https://doi.org/10.1101/825828
Epithelial cells are well-known to be modulated by extracellular mechanical factors including substrate stiffness. However, the effect of substrate stiffness on an epithelial cell’s principal function –creating an effective barrier to protect the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852d67ee3bcf7fe3ecb277f2ec04bd97
https://doi.org/10.1101/828079
https://doi.org/10.1101/828079