Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Adrian R. Laciak"'
Autor:
Shanshan Liu, Guangyu Zhu, Leah Volk, Mary Koszelak-Rosenblum, Nian N. Huang, Rory Curtis, Fazlul Karim, Adrian R. Laciak, Grant J Carr, Mousheng Wu, Michael R. Lieber
Publikováno v:
The Journal of Biological Chemistry
The endonuclease Artemis is responsible for opening DNA hairpins during V(D)J recombination and for processing a subset of pathological DNA double-strand breaks. Artemis is an attractive target for the development of therapeutics to manage various B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cbc3204e636454a1f20837a38e69a3
https://doi.org/10.1074/jbc.ra120.014136
https://doi.org/10.1074/jbc.ra120.014136
Autor:
Hsuan-Yi Wu, Yuanzhang Zheng, Adrian R. Laciak, Nian N. Huang, Mary Koszelak-Rosenblum, Andrew J. Flint, Grant Carr, Guangyu Zhu
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783031286698
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e568f5dcfb306dcd48372c3d7868753f
https://doi.org/10.1007/5584_2022_724
https://doi.org/10.1007/5584_2022_724
Publikováno v:
J Inherit Metab Dis
Certain loss-of-function mutations in the gene encoding the lysine catabolic enzyme aldehyde dehydrogenase 7A1 (ALDH7A1) cause pyridoxine-dependent epilepsy (PDE). Missense mutations of Glu427, especially Glu427Gln, account for ~30% of the mutated al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4dc27758bb6b0239d34dd4fbf12bbf
https://doi.org/10.1002/jimd.12184
https://doi.org/10.1002/jimd.12184
Autor:
Adrian R. Laciak, David A. Korasick, Kent S. Gates, Min Luo, Michael T. Henzl, John J. Tanner, Jesse W. Wyatt, Kasi Viswanatharaju Ruddraraju
Publikováno v:
Biochemistry. 56:5910-5919
Aldehyde dehydrogenase 7A1 (ALDH7A1) catalyzes the terminal step of lysine catabolism, the NAD+-dependent oxidation of α-aminoadipate semialdehyde to α-aminoadipate. Structures of ALDH7A1 reveal the C-terminus is a gate that opens and closes in res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a32c2fb2032bf194d9b5ba46827961
https://doi.org/10.1021/acs.biochem.7b00803
https://doi.org/10.1021/acs.biochem.7b00803
Autor:
Harkewal Singh, Kent S. Gates, Puminan Punthasee, Kasi Viswanatharaju Ruddraraju, Sarah M. Lewis, Roman Hillebrand, Andrea H. Cummings, John J. Tanner, Adrian R. Laciak
Publikováno v:
Biochemistry. 56(14)
Protein tyrosine phosphatase 1B (PTP1B) is a validated drug target, but it has proven difficult to develop medicinally useful, reversible inhibitors of this enzyme. Here we explored covalent strategies for the inactivation of PTP1B using a conjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d8160ccd1d52a0c727908f9503222f
https://pubmed.ncbi.nlm.nih.gov/28345882
https://pubmed.ncbi.nlm.nih.gov/28345882