Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Adrian R. Woolfitt"'
Autor:
Dongxia Wang, Bin Zhou, Theodore R. Keppel, Maria Solano, Jakub Baudys, Jason Goldstein, M. G. Finn, Xiaoyu Fan, Asheley P. Chapman, Jonathan L. Bundy, Adrian R. Woolfitt, Sarah H. Osman, James L. Pirkle, David E. Wentworth, John R. Barr
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract N-glycosylation plays an important role in the structure and function of membrane and secreted proteins. The spike protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, is
Externí odkaz:
https://doaj.org/article/94a2b1bf24dc4c3b9e141f9e202394e4
Autor:
Anne E Boyer, Maribel Gallegos-Candela, Renato C Lins, Maria I Solano, Adrian R Woolfitt, John S Lee, Daniel C Sanford, Katherine A B Knostman, Conrad P Quinn, Alex R Hoffmaster, James L Pirkle, John R Barr
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010735 (2022)
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edem
Externí odkaz:
https://doaj.org/article/e29878e29f4a4d4bab71c0fda04880e9
Autor:
Anne E. Boyer, Maribel G. Candela, Renato C. Lins, Maria I. Solano, Adrian R. Woolfitt, John Lee, Daniel C. Sanford, Katherine Knostman, Conrad. P. Quinn, Alex R. Hoffmaster, James L. Pirkle, John R. Barr
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive and late- fulminant. The toxins produced during infection exert pathologic effects leading to death, but they have not been comprehensively characterized througho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff69999f1d2d4eb67d3cd929c1c734e
https://doi.org/10.1101/2022.07.13.499850
https://doi.org/10.1101/2022.07.13.499850
Autor:
Christopher P. Klimko, Chris W Schellhase, Nancy A. Twenhafel, Jeremy A. Miller, Christopher K. Cote, Donald J. Chabot, John R. Barr, Susham S. Ingavale, Mary E. Wright, Nicholas J. Vietri, Adrian R. Woolfitt, David P Fetterer, Anne E. Boyer, Brandon Somerville, Arthur M. Friedlander, Steven A. Tobery
Publikováno v:
J Infect Dis
Background Inhalational anthrax is rare and clinical experience limited. Expert guidelines recommend treatment with combination antibiotics including protein synthesis-inhibitors to decrease toxin production and increase survival, although evidence i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f94c0f9e958153e25fd468e6ef70ce
https://doi.org/10.1093/infdis/jiaa365
https://doi.org/10.1093/infdis/jiaa365
Autor:
Tanya M. Jelacic, Adrian R. Woolfitt, Jennifer Chua, Arthur M. Friedlander, John R. Barr, Anne E. Boyer, Wilson J. Ribot
Publikováno v:
The Journal of Immunology. 204:1263-1273
The poly-γ-glutamic acid (PGA) capsule produced by Bacillus anthracis is composed entirely of d-isomer glutamic acid, whereas nonpathogenic Bacillus species produce mixed d-, l-isomer PGAs. To determine if B. anthracis PGA confers a pathogenic advan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a6851d48b1a3743b71ade6e08038633
https://doi.org/10.4049/jimmunol.1901066
https://doi.org/10.4049/jimmunol.1901066
Autor:
Asheley P. Chapman, Dongxia Wang, John R. Barr, Jakub Baudys, Maria I. Solano, Sarah H Osman, David E. Wentworth, Jason M. Goldstein, Bin Zhou, Adrian R. Woolfitt, M. G. Finn, Xiaoyu Fan, Jonathan L. Bundy, James L. Pirkle, Theodore Keppel
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
N-glycosylation plays an important role in the structure and function of membrane and secreted proteins. The spike protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, is heavily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8668d94f84665228252cd844e4851abf
http://europepmc.org/articles/PMC8651636
http://europepmc.org/articles/PMC8651636
Autor:
John R. Barr, Hercules Moura, Anne E. Boyer, Adrian R. Woolfitt, Suzanne R. Kalb, Antonis Pavlopoulos, Lisa G. McWilliams, Jurgen G. Schmidt, Rodolfo A. Martinez, David C. Ashley
Publikováno v:
Emerging Infectious Diseases, Vol 11, Iss 10, Pp 1578-1583 (2005)
Botulinum neurotoxins (BoNTs) are proteases that cleave specific cellular proteins essential for neurotransmitter release. Seven BoNT serotypes (A–G) exist; 4 usually cause human botulism (A, B, E, and F). We developed a rapid, mass spectrometry–
Externí odkaz:
https://doaj.org/article/6d55ea1c32614f4abbcdab2ba271115d
Autor:
Conrad P. Quinn, John R. Barr, Jason M. Goldstein, Adrian R. Woolfitt, Maribel Gallegos-Candela, Clinton E. Leysath, Alex R. Hoffmaster, Judith O. Brumlow, Zhaochun Chen, Anne E. Boyer, Stephen H. Leppla, Zsuzsanna Kuklenyik, Renato C. Lins, Dennis A. Bagarozzi
Publikováno v:
Anal Bioanal Chem
Inhalation of Bacillus anthracis spores can cause a rapidly progressing fatal infection. B. anthracis secretes three protein toxins: lethal factor (LF), edema factor (EF), and protective antigen (PA). EF and LF may circulate as free or PA-bound forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793a294d75c232fb953f9261a42fba0e
https://doi.org/10.1007/s00216-019-01730-4
https://doi.org/10.1007/s00216-019-01730-4
Autor:
John R. Barr, Maria I. Solano, Renato C. Lins, Adrian R. Woolfitt, Hercules Moura, Carrie L. Pierce, Anne E. Boyer, Katie Isbell, Maribel Gallegos-Candela
Publikováno v:
The Analyst. 144:2264-2274
Anthrax protective antigen (83 kDa, PA83) is an essential component of two major binary toxins produced by Bacillus anthracis, lethal toxin (LTx) and edema toxin (ETx). During infection, LTx and ETx contribute to immune collapse, endothelial dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60159d3d5003953abc4f929eb85f2364
https://doi.org/10.1039/c8an02479k
https://doi.org/10.1039/c8an02479k
Autor:
Alex R. Hoffmaster, Conrad P. Quinn, Adrian R. Woolfitt, Judy Brumlow, Gabriel T. Meister, Anne E. Boyer, Maribel Gallegos-Candela, John R. Barr, Renato C. Lins
Publikováno v:
Analytical biochemistry
Anthrax lethal factor (LF) is a zinc-dependent endoprotease and a critical virulence factor for Bacillus anthracis, the causative agent of anthrax. The mass spectrometry (MS) method for total-LF quantification includes three steps; 1) LF specific ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461c72bba79af7d4c0c622c2ce1a98ad
https://doi.org/10.1016/j.ab.2017.12.007
https://doi.org/10.1016/j.ab.2017.12.007