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of 5
pro vyhledávání: '"Adrian Paul Mander"'
Autor:
Piotr Jaroslaw Chmura, Thomas Danne, Colin Dayan, Thomas R Pieber, Chantal Mathieu, Rachel Stenson, Julie Wych, Martina Brunner, Adrian Paul Mander
Publikováno v:
BMJ Open, Vol 14, Iss 11 (2024)
Introduction Type 1 diabetes mellitus (T1DM) is a disorder that arises following the selective autoimmune destruction of the insulin-producing beta cells. Beta-cell protective or beta-cell regenerative approaches have gained wider attention, and phar
Externí odkaz:
https://doaj.org/article/397dbfd57a634ce2977b6cc88dca6295
Autor:
Michael Grayling, Adrian Paul Mander
The uniform minimum variance unbiased estimator (UMVUE) is, by definition, a solution to removing bias in estimation following a multi-stage single-arm trial with a primary dichotomous outcome. However, the UMVUE is known to have large residual mean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77015aed18667ec828338a73daf7697a
Autor:
Michael Grayling, Adrian Paul Mander
Publikováno v:
JCO Precision Oncology
PURPOSE Two-stage single-arm designs have historically been the most common design used in phase II oncology. They remain a mainstay today, particularly for trials in rare subgroups. Consequently, it is imperative such studies be designed, analyzed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e151b01462ff9d424fe1dbcbd818c20d
http://europepmc.org/articles/PMC8691516
http://europepmc.org/articles/PMC8691516
Autor:
Kara-Louise Royle, Robbie Foy, Michael Campbell, Craig Ramsay, Gareth Griffiths, Steven Penegar, Adrian Paul Mander, Gillian Shorter, Ann Henry, Adam Martin, Henry Potts, Daniel Hind, Madeleine Hurd, Alan Brennan, Sarah Alderson, Katie Gillies, Marion Campbell, Farah Elahi, Elke Gemperlé Mannion, Jacob George, Gail Mountain, Saleema Rex, Thomas Willis, Mark Peters, Robert Stein, Graeme MacLennan
Publikováno v:
Trials. 20
Introduction: Trials within Cohorts (TwiCs) is an innovative approach to the design and conduct of multiple randomised controlled trials (RCTs) (Relton et al, 2010). This approach utilises an obser ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5643b4002a42023ccb707e0b434d662f
https://doi.org/10.1186/s13063-019-3688-6
https://doi.org/10.1186/s13063-019-3688-6
Publikováno v:
Pharmaceutical Statistics
Phase I clinical trials aim to identify a maximum tolerated dose (MTD), the highest possible dose that does not cause an unacceptable amount of toxicity in the patients. In trials of combination therapies, however, many different dose combinations ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599968f8bbbb363702a863bde728db26
http://europepmc.org/articles/PMC3573644
http://europepmc.org/articles/PMC3573644